本文選題：淋巴細(xì)胞白血病患者　切入點(diǎn)：ABO血型　出處：《細(xì)胞與分子免疫學(xué)雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的了解淋巴細(xì)胞白血病患者ABO血型抗原減弱的凝集強(qiáng)度及抗體變化情況,探討適宜的血型血清學(xué)檢測(cè)方法。方法采用全自動(dòng)血型分析儀對(duì)淋巴細(xì)胞白血病患者血標(biāo)本進(jìn)行ABO血型、Rh D血型鑒定,對(duì)正定型凝集強(qiáng)度小于3+的患者血標(biāo)本,再采用試管法進(jìn)行抗原凝集強(qiáng)度檢測(cè)、吸收放散試驗(yàn)及血清抗體檢測(cè)。結(jié)果在36例ABO血型抗原減弱的淋巴細(xì)胞白血病患者中,A抗原減弱者19例(52.8%)、B抗原減弱者14例(38.9%)、AB抗原減弱者3例(8.3%),A抗原減弱者高于B抗原減弱者。血型抗原減弱的凝集強(qiáng)度強(qiáng)凝集者13例(36.1%)、較強(qiáng)凝集者10例(27.8%)、混合外觀凝集者8例(22.2%)、不凝集者5例(13.9%)。血清中抗體凝集強(qiáng)度弱于2+(2+~w)5例(13.9%),其中抗A抗體減弱者2例(5.6%),抗B抗體減弱者3例(8.3%)。對(duì)患者紅細(xì)胞進(jìn)行吸收放散試驗(yàn),凝集強(qiáng)度由陰性至強(qiáng)凝集增加到較強(qiáng)凝集至極強(qiáng)凝集,檢出了與患者血清中抗體相對(duì)應(yīng)的預(yù)期血型抗原。結(jié)論對(duì)血型抗原減弱的淋巴細(xì)胞白血病患者采用ABO正反定型、吸收放散試驗(yàn)及血清抗體檢測(cè),可正確鑒定ABO血型,確保臨床輸血安全有效。
[Abstract]:Objective to investigate the agglutination intensity and antibody changes of ABO blood group antigen attenuated in patients with lymphoblastic leukemia. Methods the blood samples of patients with lymphoblastic leukemia were identified with ABO blood group and Rh D blood group by using automatic blood type analyzer, and the blood samples with positive agglutination intensity less than 3 were identified. Then the antigen agglutination strength was detected by test tube method. Results in 36 cases of lymphoblastic leukemia with weakened ABO blood group antigen, 19 cases had abatement of TIA antigen, 14 cases had abatement of B antigen, 14 cases had abatement of AB antigen 38.9%, and 3 cases had abatement of BSA antigen were higher than that of B group. Blood group antigen weakened agglutination intensity: 13 cases with strong agglutination, 10 cases with stronger agglutination, 10 cases with strong agglutination, 8 cases with mixed appearance agglutination, 8 cases with mixed appearance agglutination, 5 cases with non-agglutination and 5 cases with no agglutination. The agglutination intensity of antibody in serum was weaker than that in 22 wks in 5 cases (13.9%). The absorption and release tests of erythrocytes were carried out in 2 cases with body weakening and 3 cases with weakened anti-B antibody. The agglutination intensity increased from negative to strong agglutination to very strong agglutination. The expected blood group antigen corresponding to the antibody in serum was detected. Conclusion ABO positive and negative typing is used in patients with lymphoblastic leukemia with weakened blood group antigen. Absorption elution test and serum antibody test can correctly identify ABO blood group and ensure the safety and effectiveness of clinical blood transfusion.
【作者單位】： 第四軍醫(yī)大學(xué)唐都醫(yī)院輸血科;
【基金】：陜西省自然科學(xué)基金(2009JM4006) 陜西省社發(fā)公關(guān)項(xiàng)目(2010K15-03-07)
【分類號(hào)】：R733.7

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 左琴琴;王滿妮;吳大洲;葉世輝;徐華;;急性髓細(xì)胞白血病患者紅細(xì)胞ABO血型抗原表達(dá)的研究[J];中國輸血雜志;2012年S1期

2 楊世明，楊棖林，解華;惡性腫瘤ABO血型抗原強(qiáng)度變化的觀察[J];第四軍醫(yī)大學(xué)學(xué)報(bào);1994年06期

3 田明麗;惡性腫瘤患者ABO血型抗原、抗體同時(shí)減弱1例[J];中國實(shí)驗(yàn)診斷學(xué);2002年03期

4 王青梅,劉景漢,王海軍;白血病ABO血型抗原改變的2例報(bào)告[J];臨床輸血與檢驗(yàn);2000年01期

5 相麗欣;陳曦陽;李忠俊;張艷;冉茜;;白血病患者ABO血型抗原病理變異5例[J];中國輸血雜志;2011年10期

6 王青梅,劉景漢,王海軍;白血病ABO血型抗原改變二例[J];中華內(nèi)科雜志;1999年11期

7 劉鋒;劉平;程平;;白血病引起ABO血型抗原表達(dá)改變1例[J];實(shí)用醫(yī)學(xué)雜志;2009年09期

8 李春霞;王英俊;;白血病致ABO血型抗原減弱2例[J];中國社區(qū)醫(yī)師(醫(yī)學(xué)專業(yè));2011年29期

9 吳爭(zhēng)勝;彭燕;;惡性腫瘤和血液病患者ABO血型抗原弱表達(dá)及輸血對(duì)策[J];全科醫(yī)學(xué)臨床與教育;2010年03期

10 黃菲;李翠瑩;甘新宇;張利;徐弘;;白血病致ABO血型抗原減弱4例[J];中國輸血雜志;2011年01期

，

本文編號(hào)：1602560