本文選題：乳腺癌　切入點(diǎn)：糖尿病　出處：《中國糖尿病雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的研究硫氧還蛋白結(jié)合蛋白(TXNIP)、前列腺跨膜上皮抗原2(STEAP2)、轉(zhuǎn)錄因子(GATA)家族中成員GATA3與糖尿病伴乳腺癌的關(guān)系,并分析患者術(shù)前及術(shù)后的血清氧化應(yīng)激指標(biāo)變化。方法檢測45例糖尿病伴乳腺癌患者癌組織及對(duì)應(yīng)癌旁組織中TXNIP、STAMP2、GAT.A3 mRNA表達(dá)量、蛋白水平及蛋白陽性表達(dá)情況,分析其臨床病理特征,以及血清氧化應(yīng)激指標(biāo)的變化。結(jié)果乳腺癌組織中TXNIP mRNA、STAMP2 mRNA、GATA3 mRNA的相對(duì)表達(dá)量均下降(P0.05)。TXNIP、STAMP2、GATA3蛋白在乳腺癌組織中的表達(dá)低于癌旁正常組織(P0.05),且3個(gè)指標(biāo)的表達(dá)陽性率為60%、66.7%、73.3%,均高于對(duì)應(yīng)癌旁正常組織中的TXNIP蛋白表達(dá)陽性率(2.2%)(P0.05)。乳腺癌組織中TXNIP、STAMP2、GATA3蛋白表達(dá)陽性率均與分化程度、淋巴結(jié)轉(zhuǎn)移與臨床分級(jí)相關(guān)(P0.05)�；颊咝g(shù)后血清MDA、髓過氧化物酶(MPO)均呈現(xiàn)先上升后下降變化趨勢,SOD及總抗氧化力(TAC)呈現(xiàn)先下降后上升的變化趨勢,術(shù)后6 d為轉(zhuǎn)折點(diǎn)。結(jié)論 TXNIP、STAMP2、GATA3及血清氧化應(yīng)激指標(biāo)可能成為糖尿病伴乳腺癌患者診斷及治療的參考指標(biāo)。
[Abstract]:Objective to study the relationship between GATA3, a member of TXNIPP, transmembrane epithelial antigen 2STEAP2, transcriptional factor, and diabetes with breast cancer. Methods the expression of TXNIPP STAMP2GAT.A3 mRNA, protein level and protein expression in 45 patients with diabetes and breast cancer were detected. The clinicopathological features were analyzed. Results the relative expression of TXNIP mRNA-STAMP2 mRNA-GATA3 mRNA in breast cancer tissues was significantly lower than that in adjacent normal tissues (P0.05U. TXNIPP2mRNA-GATA3 protein), and the positive rate of the three markers was 6066.7mRNA-GATA3, and the positive rate of these three markers was 73.3in breast cancer tissues, and in breast cancer tissues, the relative expression of STAMP2 mRNA-GATA3 protein in breast cancer tissues was significantly lower than that in adjacent normal tissues (P 0.05), and the positive rate of these three markers was 73.3%. The positive rate of expression of TXNIP protein was higher than that of the normal tissues adjacent to the corresponding carcinoma (P 0.05). The positive rate of expression of TXNIP protein in breast cancer tissues was all higher than that in the corresponding normal tissues. The correlation between lymph node metastasis and clinical grade was P0.050.The serum MDAand myeloperoxidase (MPO) of the patients increased first and then decreased. Conclusion TXNIPMP2GATA3 and serum oxidative stress may be the reference indexes for the diagnosis and treatment of diabetic patients with breast cancer.
【作者單位】： 重慶市急救醫(yī)療中心檢驗(yàn)科;
【分類號(hào)】：R587.1;R737.9

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