本文選題：乳腺黏液腺癌　切入點(diǎn)：臨床特征　出處：《重慶醫(yī)科大學(xué)》2017年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的:探討和分析乳腺黏液腺癌(MBC)的臨床與病理特征和其對(duì)預(yù)后的影響。方法:回顧性分析73例乳腺黏液腺癌患者的臨床資料、治療方式、病理學(xué)特征。根據(jù)術(shù)后腫瘤病理將其分為單純型乳腺黏液腺癌(PMBC)和混合型乳腺黏液腺癌(MMBC),結(jié)合臨床資料和病理特征分析影響其預(yù)后因素。利用SPSS19.0軟件統(tǒng)計(jì)分析黏液腺癌分子分型之間、PMBC和MMBC之間的特征差異。結(jié)果:73例乳腺黏液腺癌患者中PMBC共57例(占78.08%),MMBC共16例(占21.92%)。PMBC與MMBC在腫瘤大小、免疫組化指標(biāo)等方面并無(wú)統(tǒng)計(jì)學(xué)差異。但MMBC比PMBC的腋窩腋窩淋巴結(jié)轉(zhuǎn)移率更高(56.25%VS 7%),且差異有統(tǒng)計(jì)學(xué)意義(?2=17.461,P0.0001)。PMBC和MMBC的Ⅰ+Ⅱ期分別有52例(占98.1%)和11例(占68.2%),而Ⅲ期則分別為1例(占1.9%)和5例(占31.2%),兩者有統(tǒng)計(jì)學(xué)差異(?2=9.904,P0.0020)。分子分型中Luminal A型38例(占57.58%),Luminal B型23例(占34.85%),HER-2過(guò)表達(dá)型1例(占1.37%),三陰型4例(占5.48%)。激素受體陽(yáng)性的黏液腺癌與激素受體陰性之間比較,腫瘤大小、區(qū)域淋巴結(jié)轉(zhuǎn)移等均未見(jiàn)有統(tǒng)計(jì)學(xué)差異。全組隨訪時(shí)間10~105個(gè)月,2例MMBC出現(xiàn)局部復(fù)發(fā)或遠(yuǎn)處轉(zhuǎn)移,1例死亡,非乳腺癌相關(guān)死亡2例,其余均無(wú)瘤存活。結(jié)論:乳腺黏液腺癌具有相對(duì)惰性的生物學(xué)行為,激素受體陽(yáng)性率高,腋窩淋巴結(jié)轉(zhuǎn)移少見(jiàn),腫瘤復(fù)發(fā)率低,預(yù)后好。病理亞型中單純型乳腺黏液腺癌最為多見(jiàn),分子分型主要以Luminal A型和Luminal B為主。腋窩淋巴結(jié)狀況是MBC預(yù)后最為重要的因素。MMBC腋窩淋巴結(jié)轉(zhuǎn)移率高于PMBC,且其預(yù)后相對(duì)較差。
[Abstract]:Objective: to investigate and analyze the clinical and pathological features of breast mucinous adenocarcinoma (MBC) and its influence on prognosis. Methods: the clinical data and treatment methods of 73 cases of breast mucinous adenocarcinoma were retrospectively analyzed. According to the pathological features, the tumor was divided into simple mammary mucinous adenocarcinoma (PMBCC) and mixed mammary mucinous adenocarcinoma (MMBC). The prognostic factors were analyzed by SPSS19.0 software combined with clinical data and pathological characteristics. Results among 73 cases of breast mucinous adenocarcinoma, 57 cases (78.08%) had PMBC and 16 cases (21.92%) had MMBC. There was no statistical difference in immunohistochemical markers, but the rate of axillary lymph node metastasis in MMBC was higher than that in axillary axillary lymph node of PMBC (56.25VS7T), and the difference was statistically significant. (2) there were 52 cases (98.1%) and 11 cases (68.2%) in stage 鈪，

本文編號(hào)：1581751