本文選題：食管鱗癌　切入點(diǎn)：CYFRA21-1　出處：《青海大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討食管鱗癌患者手術(shù)治療前后血清CYFRA21-1、CA125、SCC-Ag水平變化的臨床意義。方法:選取2014年12月-2016年10月共收集符合研究條件病例40例,所有患者均行標(biāo)準(zhǔn)的食管癌根治手術(shù),并采集患者手術(shù)前1周和術(shù)后2周、術(shù)后1月晨起空腹靜脈血5ml送核醫(yī)學(xué)科,應(yīng)用夾心式原理采用羅氏(Roche)Cobas8000全自動電化學(xué)發(fā)光免疫分析系統(tǒng)及羅氏相配套腫瘤標(biāo)記物檢測試劑盒進(jìn)行檢測。所有數(shù)據(jù)建立采用Excel軟件,數(shù)據(jù)統(tǒng)計用SPSS17.0分析軟件。用均數(shù)±標(biāo)準(zhǔn)差(?X±S)表示計量資料,采用重復(fù)測量方差分析方法對患者術(shù)前1周、術(shù)后2周及術(shù)后1月的腫瘤標(biāo)記物濃度水平進(jìn)行分析,不同分期腫瘤標(biāo)記物濃度比較采用兩獨(dú)立樣本t檢驗(yàn)或t′檢驗(yàn),檢驗(yàn)水準(zhǔn)α=0.05。結(jié)果:1、食管鱗癌患者血清中CYFRA21-1、CA125、SCC-Ag濃度水平術(shù)后2周較術(shù)前1周明顯下降,均有顯著性差異(P0.05);術(shù)后1月較術(shù)前1周CYFRA21-1和CA125明顯下降,有顯著性差異(P0.05),而SCC-Ag無顯著性差異(P㧐0.05);術(shù)后1月較術(shù)后2周CYFRA21-1和CA125明顯下降,有顯著性差異(P0.05),SCC-Ag無顯著性差異(P㧐0.05)。2、腫瘤分期Ⅱ期與Ⅲa期比較,血清中CYFRA21-1在術(shù)前1周、術(shù)后2周及術(shù)后1月均有顯著性差異(P0.05);血清中CA125與SCC-Ag在術(shù)前1周、術(shù)后2周及術(shù)后1月均無顯著性差異(P0.05)。結(jié)論:1、血清中CYFRA21-1、CA125濃度水平與食管鱗癌患者病期呈正相關(guān),CYFRA21-1血清水平與腫瘤分期呈正相關(guān),CA125及SCC-Ag與腫瘤分期無關(guān)。血清CYFRA21-1與CA125水平術(shù)后明顯持續(xù)降低,說明術(shù)中瘤體及淋巴結(jié)清掃較徹底,表示食管鱗癌根治手術(shù)治療成功;反之則表示病灶殘留等可能,需術(shù)后相應(yīng)的放、化療;血清水平下降后再次升高,則提示可能存在疾病復(fù)發(fā)等情況。所以動態(tài)檢測CYFRA21-1及CA125的血清水平,能為食管鱗癌患者的病情判斷、手術(shù)療效的觀察、預(yù)后判斷及術(shù)后制定更合理的個體化治療方案提供重要的臨床依據(jù)。2、本實(shí)驗(yàn)中,SCC-Ag與食管鱗癌相關(guān)性較差,其臨床意義有待于進(jìn)一步大樣本的研究。
[Abstract]:Objective: to investigate the clinical significance of serum CYFRA21-1C125 and SCC-Ag levels in patients with esophageal squamous cell carcinoma before and after surgical treatment. Methods: 40 patients with esophageal carcinoma were collected from December 2014 to October 2016. The patients were collected 1 week before operation and 2 weeks after operation, and 5 ml of fasting venous blood was sent to the Department of Nuclear Medicine on the morning of January. The sandwich principle was applied to the detection of Rochea Rochea Cobas8000 automatic electrochemiluminescence immunoassay system and Roche matching tumor marker detection kit. All the data were established by Excel software. SPSS17.0 software was used to analyze the data. X 鹵S (X 鹵S) was used to analyze the tumor marker concentration of the patients at 1 week before operation, 2 weeks after operation and January after operation by means of repeated measurement variance analysis. Two independent samples t test or t 'test were used to compare the tumor marker concentration in different stages. The test level was 0. 05. Results the serum level of CYFRA21-1 CA125 and SCC-Ag in esophageal squamous cell carcinoma patients decreased significantly 2 weeks after operation compared with 1 week before operation. There was significant difference in CYFRA21-1 and CA125 between January and one week after operation (P 0.05), but there was no significant difference in SCC-Ag (P > 0.05). On January, CYFRA21-1 and CA125 were significantly lower than those in 2 weeks after operation (P < 0.05). There was no significant difference in SCC-Ag between two weeks after operation (P > 0.05). Compared with stage 鈪，

本文編號：1575392