本文選題：高密度脂蛋白膽固醇　切入點(diǎn)：胃癌　出處：《蘭州大學(xué)》2017年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的:系統(tǒng)評(píng)價(jià)高密度脂蛋白膽固醇(HDL-C)與胃癌易感性的關(guān)系。方法:計(jì)算機(jī)檢索Pub Med(建庫(kù)-2016年12月1日)、Embase(建庫(kù)-2016年12月1日)、The Cochrane Library(建庫(kù)-2016年12月1日)、中國(guó)知網(wǎng)(建庫(kù)-2016年12月1日)、萬(wàn)方數(shù)據(jù)庫(kù)(建庫(kù)-2016年12月1日)、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(建庫(kù)-2016年12月1日)和維普中文科技期刊數(shù)據(jù)庫(kù)(建庫(kù)-2016年12月1日),搜集國(guó)內(nèi)外公開(kāi)發(fā)表的有關(guān)高密度脂蛋白膽固醇(HDL-C)與胃癌易感性的研究。由2位研究人員獨(dú)立完成文獻(xiàn)的篩選,提取相關(guān)資料并進(jìn)行文獻(xiàn)質(zhì)量評(píng)價(jià)。采用Stata12.0軟件進(jìn)行數(shù)據(jù)處理。結(jié)果:共納入18項(xiàng)研究,包括1565例胃癌患者和1107例對(duì)照。Meta分析結(jié)果顯示,胃癌組患者的HDL-C水平要顯著低于健康對(duì)照組[SMD=-0.90,95%CI=(-1.21,-0.59),P0.001]。進(jìn)行亞組分析后,提示未接受手術(shù)[SMD術(shù)前=-1.30,95%CI(-1.93,-0.68),P0.001]或Ⅲ-Ⅳ期[SMDⅢ-Ⅳ=-1.56,95%CI(-1.89,-1.22),P0.001]胃癌患者的HDL-C水平均低于健康對(duì)照組,且差異有統(tǒng)計(jì)學(xué)意義。結(jié)論:胃癌患者體內(nèi)HDL-C水平要顯著低于健康對(duì)照人群。HDL-C可以作為胃癌易感性的血清學(xué)標(biāo)志物。
[Abstract]:Objective: to evaluate the relationship between high density lipoprotein cholesterol (HDL-C) and susceptibility to gastric cancer. Methods: Pub Medwas was searched by computer to search the Cochrane Library on December 1st 2016. (Jianking-#date0#), Wanfang Database (Jianking-#date1#), China Biomedical Literature Database (Jianking-#date2#) and Weipu Chinese Science and Technology Journal Database (Jianking-#date2#), collected and collected. Studies on HDL-C) and susceptibility to gastric cancer were published at home and abroad. Data were processed by Stata12.0 software. Results: a total of 18 studies were included, including 1 565 patients with gastric cancer and 1107 controls. The level of HDL-C in gastric cancer group was significantly lower than that in healthy control group [SMD-0.90 ~ 95CII = -1.21U -0.59 P0.001]. After subgroup analysis, it was suggested that the HDL-C level in patients with gastric cancer was lower than that in healthy control group [before SMD operation -1.30 ~ 9595 ci -1.93U -0.68 + P0.001] or in stage 鈪，

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