本文選題：乳腺腫瘤　切入點：CD　出處：《臨床與實驗病理學雜志》2017年03期 　論文類型：期刊論文

【摘要】：目的 探討CD90在乳腺浸潤性導管癌中的表達及其與臨床病理特征、分子分型的相關性。方法 構建80例乳腺浸潤性導管癌和20例乳腺良性病變的組織芯片,采用免疫組化Max Vision法檢測乳腺不同病變組織中CD90、ER、PR、Ki-67和HER-2的表達水平,并進一步分析其相關性。結果 CD90在乳腺浸潤性導管癌和乳腺良性病變中的陽性率分別為62.5%和20.0%,兩者差異有統(tǒng)計學意義(P0.001);CD90表達與乳腺浸潤性導管癌淋巴結轉移相關(P0.05),與患者年齡、腫瘤大小、TNM分期及組織學分級無關(P0.05);在乳腺浸潤性導管癌不同分子亞型中,CD90陽性率以Luminal A型最低(40.0%)、三陰型最高(82.4%),各亞型之間差異有統(tǒng)計學意義(P0.05);CD90與ER(r=-0.342,P0.05)、PR(r=-0.374,P0.05)表達呈負相關,與Ki-67表達之間無相關性(r=0.084,P0.05)。結論 CD90表達與乳腺癌分子分型有關,其高表達提示患者預后不良。
[Abstract]:Objective to investigate the expression of CD90 in invasive ductal carcinoma of the breast and its correlation with clinicopathological features and molecular typing. Methods tissue microarrays were constructed in 80 cases of invasive ductal carcinoma of the breast and 20 cases of benign breast lesions. Immunohistochemical Max Vision method was used to detect the expression of Ki-67 and HER-2 in different breast lesions. Results the positive rates of CD90 in invasive ductal carcinoma of the breast and benign breast lesions were 62.5% and 20.0 respectively. The difference was statistically significant between the expression of CD90 and lymph node metastasis of invasive ductal carcinoma of breast. Guan P0.05, with patient age, The positive rate of CD90 in different molecular subtypes of invasive ductal carcinoma of breast was the lowest in Luminal A and the lowest in Luminal A, and the highest in three negative types. There was a significant difference between the two subtypes. There was a negative correlation between the positive rate of CD90 and ERr-0.342P0.05P0.05and ERr-0.342P0.05P0.05) in breast infiltrating ductal carcinoma, and the positive rate of CD90 was negatively correlated with that of Luminal A, and the highest of three negative type was 82.40.The expression of CD90 was negatively correlated with the expression of ERr-0.342P0.05P0.05) in breast infiltrating ductal carcinoma. There was no correlation between CD90 expression and Ki-67 expression. Conclusion the expression of CD90 is related to the molecular classification of breast cancer, and its high expression indicates poor prognosis.
【作者單位】： 江西省人民醫(yī)院臨床醫(yī)學研究所;江西省人民醫(yī)院病理科;江西省人民醫(yī)院體檢科;
【分類號】：R737.9
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本文編號：1564299