本文選題：奧曲肽　切入點(diǎn)：溴隱亭　出處：《山東醫(yī)藥》2017年11期 　論文類型：期刊論文

【摘要】：目的觀察短效、長(zhǎng)效奧曲肽及溴隱亭序貫應(yīng)用治療侵襲海綿竇的生長(zhǎng)激素型垂體瘤的療效。方法將16例侵襲海綿竇的生長(zhǎng)激素型垂體瘤患者隨機(jī)分為觀察組和對(duì)照組,各8例。觀察組患者先皮下注射短效奧曲肽,每次100μg,3次/d,持續(xù)1周;然后臀部肌肉深部注射長(zhǎng)效奧曲肽,20 mg/次,每28 d注射1次,連用3次;然后口服嗅隱亭7.5 mg/d,3個(gè)月。對(duì)照組患者臀部肌肉深部注射長(zhǎng)效奧曲肽,每次20 mg,每28 d注射1次,連用6個(gè)月。觀測(cè)并比較兩組患者治療前、后的臨床癥狀評(píng)分、血清GH谷值、血清胰島素樣生長(zhǎng)因子1(IGF-1)、腫瘤體積。統(tǒng)計(jì)兩組患者胃腸道不良反應(yīng)發(fā)生情況及總治療費(fèi)用。結(jié)果兩組患者治療前后的臨床癥狀評(píng)分、血清GH谷值、血清IGF-1、腫瘤體積組間比較P均0.05。觀察組2例(25%)、對(duì)照組5例(62.5%)發(fā)生胃腸道不良反應(yīng),兩組胃腸道不良反應(yīng)發(fā)生率相比P0.05。觀察組總費(fèi)用為(33 000±2 000)元,對(duì)照組為(55 000±9 000)元,觀察組低于對(duì)照組(P0.05)。結(jié)論短效、長(zhǎng)效奧曲肽及溴隱亭序貫應(yīng)用治療侵襲海綿竇的生長(zhǎng)激素型垂體瘤療效與單用長(zhǎng)效奧曲肽相當(dāng),但是能夠避免胃腸道不良反應(yīng),減輕患者的藥物經(jīng)濟(jì)負(fù)擔(dān)。
[Abstract]:Objective to observe the efficacy of short-term, long-acting octreotide and bromocriptine in the treatment of growth hormone type pituitary adenomas invading cavernous sinus.Methods Sixteen patients with growth hormone pituitary adenoma invading cavernous sinus were randomly divided into observation group and control group. Eight patients in each group received subcutaneous injection of short-acting octreotide three times a day for one week, and then deep hip muscle injection of long-acting octreotide for 20 mg/, once every 28 days for 3 times. The patients in the control group were injected with long-acting octreotide 20 mg every 28 days for 6 months. The clinical symptom scores before and after treatment were observed and compared, and the serum GH valley values were compared between the two groups before and after treatment. Serum insulin-like growth factor (IGF-1), tumor volume, incidence of gastrointestinal adverse reactions and total cost of treatment were analyzed. Results the clinical symptom scores and serum GH valley values were measured before and after treatment in the two groups. Serum IGF-1 and tumor volume (P < 0.05). Adverse gastrointestinal reactions occurred in the observation group (n = 2) and in the control group (n = 5). The incidence of adverse gastrointestinal reactions in the two groups was higher than that in the control group (P 0.05). The total cost of the observation group was 33,000 鹵2,000 yuan, and that of the control group was 55,000 鹵9,000 yuan. Conclusion the short-term, long-acting octreotide and bromocriptine sequential treatment of growth hormone type pituitary adenoma invading cavernous sinus is similar to that of long-acting octreotide alone, but it can avoid the adverse effects of gastrointestinal tract. Reduce the patient's drug economic burden.
【作者單位】： 昆明醫(yī)科大學(xué)第一附屬醫(yī)院;
【基金】：云南省應(yīng)用基礎(chǔ)研究基金資助項(xiàng)目(2015FB051)
【分類號(hào)】：R736.4

【相似文獻(xiàn)】

相關(guān)期刊論文 前4條

1 楊文燕;吳建新;戴強(qiáng);江佛湖;趙力民;張燕捷;朱黎明;王碧君;;長(zhǎng)效奧曲肽影響大鼠肝纖維化形成的研究[J];中國(guó)醫(yī)藥導(dǎo)報(bào);2007年26期

2 楊文燕;吳建新;戴強(qiáng);江佛湖;;長(zhǎng)效奧曲肽對(duì)大鼠肝纖維化門靜脈高壓形成的影響[J];世界華人消化雜志;2008年25期

3 楊文燕;戴強(qiáng);;長(zhǎng)效奧曲肽對(duì)肝纖維化大鼠IL-6、IL-8的影響[J];重慶醫(yī)學(xué);2009年03期

4 ;[J];;年期

，

本文編號(hào)：1563452