本文關(guān)鍵詞： 肺浸潤(rùn)性腺癌 能譜CT Ki-　出處：《臨床放射學(xué)雜志》2017年02期 　論文類(lèi)型：期刊論文

【摘要】：目的探討肺浸潤(rùn)性腺癌的能譜CT碘基物質(zhì)分析與Ki-67表達(dá)程度的相關(guān)性。方法回顧性分析經(jīng)病理證實(shí)的44例肺浸潤(rùn)性腺癌患者資料,所有患者的免疫組織化學(xué)指標(biāo)均包括Ki-67,并且于術(shù)前行能譜CT增強(qiáng)掃描,包括動(dòng)脈期及靜脈期,分別延遲25 s、55 s。根據(jù)CT縱隔窗上腫瘤含實(shí)性成分的多少,分成實(shí)性結(jié)節(jié)組(18例)、m GGN組(19例)、p GGN組(7例)。采用Spearman相關(guān)法分析所有病例中Ki-67與動(dòng)脈期及靜脈期腫瘤平均碘基值的相關(guān)性,及與腫瘤實(shí)性成分多少的相關(guān)性;分別分析實(shí)性結(jié)節(jié)組、m GGN組、p GGN組中Ki-67與動(dòng)脈期及靜脈期腫瘤平均碘基值的相關(guān)性。結(jié)果所有病例中,Ki-67與動(dòng)脈期及靜脈期腫瘤平均碘基值均呈負(fù)相關(guān)性(P0.05)。另外,Ki-67與肺癌結(jié)節(jié)中實(shí)性成分呈正相關(guān)(P=0.02,r=0.36)。實(shí)性結(jié)節(jié)組和m GGN組中,Ki-67與動(dòng)脈期及靜脈期腫瘤平均碘基值均呈負(fù)相關(guān)性(P0.05)。p GGN組中,Ki-67與動(dòng)脈期及靜脈期腫瘤平均碘基值均無(wú)相關(guān)性(P0.05)。Ki-67分組中動(dòng)脈期及靜脈期平均碘基值均有明顯差異性(P0.05)。結(jié)論肺浸潤(rùn)性腺癌的碘基值與Ki-67具有較好的負(fù)相關(guān)性,在評(píng)估腫瘤增殖能力上可以對(duì)Ki-67進(jìn)行補(bǔ)充。
[Abstract]:Objective to investigate the correlation between the expression of Ki-67 and the level of Ki-67 expression in invasive lung adenocarcinoma. Methods 44 cases of lung invasive adenocarcinoma confirmed by pathology were retrospectively analyzed. Ki-67 was included in all patients, and enhanced EDS CT scan was performed before operation, including arterial phase and venous phase, with a delay of 25 s or 55 s. According to the solid composition of the tumor in the mediastinal window of CT, A total of 18 cases of solid nodules were divided into two groups: GGN group (n = 19) and GGN group (n = 7). Spearman correlation method was used to analyze the correlation between Ki-67 and the mean iodine base value of arterial and venous tumors, and the correlation between Ki-67 and tumor solid composition. The correlation between Ki-67 and the mean iodine base value of arterial and venous phase tumors in solid GGN group was analyzed respectively. Results in all cases, Ki-67 was negatively correlated with the mean iodine base value in arterial phase and venous phase. In addition, Ki-67 had a negative correlation with the mean iodine base value in arterial phase and venous phase. There was a positive correlation between Ki-67 and the mean iodine base value in arterial and venous phase in solid nodule group and m GGN group. There was no significant difference between Ki-67 value and average iodine base value in arterial phase and venous phase in P0.05 + p GGN group. There were significant differences in the average iodine base values in arterial and venous phases in P0.05. Ki-67 groups. Conclusion there is a good negative correlation between iodine base value and Ki-67 in pulmonary infiltrating adenocarcinoma. Ki-67 may be supplemented in evaluating tumor proliferation.
【作者單位】： 大連醫(yī)科大學(xué)附屬第一醫(yī)院放射科;
【分類(lèi)號(hào)】：R734.2;R730.44

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