本文關(guān)鍵詞： 百合類方 腫瘤 抑郁 焦慮 臨床研究　出處：《湖北中醫(yī)藥大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:本研究通過了解惡性腫瘤患者抑郁、焦慮情況,探討百合類方治療腫瘤相關(guān)性抑郁、焦慮的療效,為中醫(yī)藥在臨床治療改善惡性腫瘤患者心理狀態(tài)提供參考。方法:將203例惡性腫瘤相關(guān)性抑郁、焦慮的患者隨機分為2組,對照組給予心理疏導療法,觀察組在心理疏導的基礎(chǔ)上,根據(jù)患者辨證分型,分別給予百合類方加減治療。通過向患者發(fā)放抑郁自評量表(SDS)和焦慮自評量表(SAS),評價患者焦慮和抑郁情況。發(fā)放生活質(zhì)量核心問卷30個條目(EORTC QLQ—C30)量表,評估患者生活質(zhì)量,其中診斷為輕度腫瘤相關(guān)性抑郁患者67例,中度19例,重度4例。診斷為輕度腫瘤相關(guān)性焦慮患者74例,中度33例,重度6例。所有病例根據(jù)對照組及觀察組所訴方法,連續(xù)治療2個療程(14天為一個療程,共28天),于治療的第1天,第28天收集臨床數(shù)據(jù)。統(tǒng)計學數(shù)據(jù)采用SPSS 23.0軟件包進行分析,結(jié)果以均數(shù)土標準差(?X土s)表示。觀察組與對照組之間比較采用T檢驗,P0.05表示有統(tǒng)計學意義。結(jié)果:研究結(jié)果顯示:腫瘤相關(guān)性抑郁及焦慮的患者經(jīng)28天治療后對照組僅情緒功能單項評分較治療前提高,差異有統(tǒng)計學意義(P0.01)。觀察組在軀體功能、情緒功能及總體生活質(zhì)量評分均較治療前提高,差異有統(tǒng)計學意義(P0.05或P0.01),與對照組相比,觀察組的軀體功能、情緒功能及總體生活質(zhì)量評分均高于對照組,差異有統(tǒng)計學意義(P0.05或P0.01)。治療第28天,對照組3個主要癥狀領(lǐng)域量表評分均無改善,差異無統(tǒng)計學意義(PO.05),觀察組疲乏、惡心嘔吐單項評分均較治療前降低,差異有統(tǒng)計學意義(P0.05或P0.01),且低于對照組,差異有統(tǒng)計學意義(P0.05或P0.01)。治療第28天,對照組6個單項領(lǐng)域量表評分均無改善,差異無統(tǒng)計學意義(P0.05),觀察組在失眠、食欲減弱、便秘、腹瀉單項評分均較治療前降低,差異有統(tǒng)計學意義(P0.05或P0.01),且低于對照組,差異有統(tǒng)計學意義(P0.05或P0.01)。治療第28天,2組SDS及SAS評分均較治療前有所降低,差異有統(tǒng)計學意義(P0.01)。觀察組SDS及SAS評分改善優(yōu)于對照組,差異有統(tǒng)計學意義(P0.05或P0.01)。結(jié)論:百合類方能在一定程度上改善惡性腫瘤相關(guān)性抑郁及焦慮患者的抑郁、焦慮情緒,提高患者的生活質(zhì)量,改善睡眠、飲食、消化等相關(guān)癥狀。對腫瘤相關(guān)性抑郁及焦慮狀態(tài)的干預(yù)有效。
[Abstract]:Objective: to investigate the efficacy of Liliangfang in the treatment of tumor-related depression and anxiety by investigating the depression and anxiety in patients with malignant tumor. Methods: 203 patients with malignant tumor-associated depression and anxiety were randomly divided into two groups. On the basis of psychological guidance, the observation group was classified according to the syndrome differentiation of the patients. The patients' anxiety and depression were evaluated by self-rating depression scale (SDS) and self-rating anxiety scale (SAS), and the quality of life was evaluated by issuing 30 items of core questionnaire of quality of life (EORTC QLQ-C30). Among them, 67 cases were diagnosed as mild tumor-associated depression, 19 cases as moderate, 4 cases as severe. 74 cases were diagnosed as mild tumor-associated anxiety, 33 cases as moderate, 6 cases as severe. The clinical data were collected on the first day and the 28th day of treatment. The statistical data were analyzed by SPSS 23.0 software package. Results: the results showed that the patients with tumor-related depression and anxiety were only emotional function sheet after 28 days of treatment. Item score was higher than that before treatment. The scores of somatic function, emotional function and total quality of life in the observation group were higher than those before treatment, and the difference was statistically significant (P0.05 or P0.01). Compared with the control group, the somatic function of the observation group was higher than that of the control group. The scores of emotional function and total quality of life were significantly higher than those of the control group (P 0.05 or P 0.01). On the 28th day of treatment, the scores of the three main symptom areas in the control group were not improved, and the difference was not statistically significant. The single score of nausea and vomiting was lower than that before treatment, the difference was statistically significant (P 0.05 or P 0.01), and the difference was lower than that of the control group (P 0.05 or P 0.01). On the 28th day of treatment, the scores of the six single field scales in the control group were not improved. There was no significant difference (P 0.05). The single score of insomnia, decreased appetite, constipation and diarrhea in the observation group was significantly lower than that before treatment (P 0.05 or P 0.01), and was lower than that in the control group. On the 28th day of treatment, the scores of SDS and SAS in the two groups were lower than those before treatment, and the difference was statistically significant (P 0.01). The improvement of SDS and SAS scores in the observation group was better than that in the control group. Conclusion: lily prescription can improve the depression and anxiety of patients with malignant tumor-related depression and anxiety to a certain extent, improve the quality of life of patients, improve sleep, diet, etc. Digestion and other related symptoms. Tumor-related depression and anxiety state intervention is effective.
【學位授予單位】：湖北中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R730.5

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