本文關(guān)鍵詞： 顳葉 腦腫瘤 認(rèn)知功能 腦結(jié)構(gòu)網(wǎng)絡(luò) 信息傳輸效率　出處：《中國(guó)科學(xué):生命科學(xué)》2017年07期 　論文類型：期刊論文

【摘要】：本研究旨在結(jié)合圖論討論顳葉腫瘤對(duì)整個(gè)大腦結(jié)構(gòu)網(wǎng)絡(luò)的影響以及患者認(rèn)知功能變化情況.本文基于彌散張量成像技術(shù),構(gòu)建顳葉腫瘤患者以及正常對(duì)照組腦結(jié)構(gòu)網(wǎng)絡(luò),依據(jù)纖維束連接長(zhǎng)度,將整個(gè)腦網(wǎng)絡(luò)分為3個(gè)子網(wǎng)絡(luò),對(duì)比分析各個(gè)子網(wǎng)絡(luò)的網(wǎng)絡(luò)參數(shù)全局效率和局部效率,進(jìn)而對(duì)顳葉腫瘤患者大腦內(nèi)纖維束的再生以及消亡情況做簡(jiǎn)單分析.并對(duì)兩組受試者進(jìn)行認(rèn)知能力評(píng)估,分析患者認(rèn)知能力與節(jié)點(diǎn)效率之間的相關(guān)性,從而得到患者大腦認(rèn)知分布情況.研究結(jié)果顯示,全局效率和局部效率在全腦網(wǎng)絡(luò)結(jié)構(gòu)中均無(wú)顯著差異,子網(wǎng)絡(luò)拓?fù)鋮?shù)顯示,僅在短距離子網(wǎng)絡(luò)中,患者組較正常組有顯著升高,局部參數(shù)研究結(jié)果顯示,正常組均優(yōu)于患者組,且患者認(rèn)知能力普遍低于正常組.腦區(qū)內(nèi)部纖維束再生以及不同功能區(qū)之間纖維束連接發(fā)生變化從而使得顳葉腫瘤患者腦結(jié)構(gòu)網(wǎng)絡(luò)發(fā)生重組,且患者在注意力、記憶功能、學(xué)習(xí)能力等方面較正常人有顯著降低,患者額顳-頂葉部分腦區(qū)參與認(rèn)知過程,特殊腦區(qū)信息處理效率的變化可間接反映認(rèn)知變化情況.
[Abstract]:The purpose of this study was to discuss the effects of temporal lobe tumors on the whole brain structure network and the changes of cognitive function in patients with temporal lobe tumors. According to the fiber bundle connection length, the whole brain network is divided into three subnetworks, and the global and local efficiency of the network parameters are compared and analyzed. Then, the regeneration and extinction of the fibrous bundles in the brain of patients with temporal lobe tumor were analyzed, and the cognitive ability of the two groups was evaluated to analyze the correlation between the cognitive ability and node efficiency. The results show that there is no significant difference between global efficiency and local efficiency in the whole brain network structure, and the topological parameters of the subnetwork are only shown in the short distance subnetwork. The results of local parameter study showed that the normal group was superior to the patient group. And the cognitive ability of the patients was generally lower than that of the normal group. The regeneration of the fiber bundle in the brain and the changes of the fibrous bundle connections between the different functional areas resulted in the reorganization of the brain structure network in the patients with temporal lobe tumors, and the patients' attention and memory function. The learning ability of the patients was significantly lower than that of the normal subjects, and the part of the frontotemporal and parietal regions was involved in the cognitive process, and the change of information processing efficiency in the special brain regions could indirectly reflect the cognitive changes.
【作者單位】： 南京航空航天大學(xué)自動(dòng)化學(xué)院;
【分類號(hào)】：R739.4

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本文編號(hào)：1533541