惡性血液病患者侵襲性真菌病初級預(yù)防的現(xiàn)狀與未來
發(fā)布時(shí)間:2018-02-22 12:26
本文關(guān)鍵詞: 惡性血液病 侵襲性真菌病 抗真菌初級預(yù)防 出處:《中國實(shí)驗(yàn)血液學(xué)雜志》2017年02期 論文類型:期刊論文
【摘要】:侵襲性真菌病在惡性血液病化療和造血干細(xì)胞移植患者中發(fā)病率及病死率很高。初級預(yù)防可有效減少侵襲性真菌病的發(fā)生,使患者對化療和造血干細(xì)胞移植的耐受性更佳,治療費(fèi)用更低,預(yù)后更好。氟康唑、伊曲康唑、泊沙康唑、卡泊芬凈、米卡芬凈等抗真菌藥物已被多個(gè)指南推薦用于初級預(yù)防。侵襲性真菌病風(fēng)險(xiǎn)預(yù)估、新型藥物研發(fā)、藥代動力學(xué)研究、綜合預(yù)防措施的開展將使初級預(yù)防更加科學(xué)、合理、有效。本文就近年來惡性血液病患者侵襲性真菌病初級預(yù)防的進(jìn)展作一綜述
[Abstract]:Invasive fungal disease stem cell transplant recipients with high morbidity and mortality in malignant hematologic disease. Chemotherapy and hematopoietic primary prevention can effectively reduce the incidence of invasive fungal disease, so that patients on chemotherapy and hematopoietic stem cell transplantation are better tolerated, lower cost of treatment, the prognosis is better. Fluconazole, itraconazole, Bo Sha conazole, caspofungin, Mika Finn Jing and other antifungal drugs have been a guide recommended for primary prevention. Invasive fungal disease risk prediction, the research and development of new drugs, pharmacokinetics, comprehensive preventive measures will be carried out to make primary prevention more scientific, reasonable and effective. This article reviews the recent progress in patients with malignant blood disease primary prevention of invasive fungal disease
【作者單位】: 中國人民解放軍總醫(yī)院血液科、解放軍醫(yī)學(xué)院;中國人民解放軍總醫(yī)院海南分院血液科;
【基金】:解放軍總醫(yī)院科技創(chuàng)新苗圃基金面上項(xiàng)目(13KMM01)
【分類號】:R733;R519
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