本文關(guān)鍵詞： 胃底折疊 食管癌 反流 Meta分析　出處：《蘭州大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:采用循證醫(yī)學(xué)的方法系統(tǒng)評(píng)價(jià)食管切除術(shù)吻合口行常規(guī)吻合與附加胃底折疊術(shù)吻合術(shù)后的抗反流效果。方法:通過(guò)計(jì)算機(jī)檢索PubMed、EMBASE、Web of Knowledge、The Cochrane Library、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)、萬(wàn)方數(shù)據(jù)、中國(guó)知網(wǎng)和維普數(shù)據(jù)庫(kù),查找關(guān)于吻合口常規(guī)吻合與附加胃底折疊術(shù)兩種吻合方式對(duì)食管切除術(shù)后抗返流效果的研究,檢索時(shí)限均從建庫(kù)至2015年1月。資料的提取、質(zhì)量的評(píng)價(jià)是通過(guò)兩個(gè)實(shí)驗(yàn)人員單獨(dú)完成的,采用的標(biāo)準(zhǔn)是Cochrane系統(tǒng)評(píng)價(jià)的方法,然后對(duì)數(shù)據(jù)的Meta分析通過(guò)RevMan 5.3軟件來(lái)完成。結(jié)果:共納入11個(gè)RCT試驗(yàn),1391例患者。Meta分析結(jié)果顯示:與常規(guī)吻合相比,附加胃底折疊術(shù)術(shù)后能明顯降低吻合口反流發(fā)生率(OR=0.18,95%CI:0.09~0.33,P0.00001)并不會(huì)增加術(shù)后吻合口狹窄率(OR=0.53,95%CI:0.28~0.99,P=0.05)。結(jié)論:本Meta分析結(jié)果顯示:食管切除術(shù)后吻合口附加胃底折疊術(shù)能明顯減少吻合口反流情況的發(fā)生。
[Abstract]:Objective: to evaluate the anti-reflux effect of esophagectomy anastomosis with routine anastomosis and additional fundus fold anastomosis with evidence-based medicine. Methods: a computer-based search was made for the Cochrane Library of PubMedus EMBASE of knowledge, and the Chinese Biomedical Literature Database was used to evaluate the efficacy of Evidence-based Medicine (EBM) in the treatment of esophagectomy. Wanfang data, China knowledge Network and Weip Database, to find out about the anastomotic anastomosis and the additional stomach fundus anastomosis two kinds of anastomosis to the esophagectomy anti-reflux effect research, the retrieval time is from the establishment of the database to January 2015. The quality evaluation is done by two experimenters alone, and the standard used is the method of Cochrane system evaluation. Then the Meta analysis of the data was performed by RevMan 5.3 software. Results: a total of 1391 patients were included in 11 RCT trials. The incidence of anastomotic regurgitation was significantly decreased after additional fundus folding. Conclusion: the results of Meta analysis showed that anastomotic anastomotic plus fundus folding after esophagectomy could significantly decrease the rate of anastomotic stricture. Conclusion: after esophagectomy, anastomotic plus fundus folding can significantly reduce the rate of anastomotic stricture (P 0.00001). Conclusion: after esophagectomy, anastomotic anastomosis plus fundus folding can significantly reduce the rate of anastomotic stenosis after esophagectomy. Conclusion: after esophagectomy, the rate of anastomosis plus fundus folding can be significantly reduced. The occurrence of anastomotic regurgitation.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R735.1

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本文編號(hào)：1505726