本文關(guān)鍵詞： 宮頸癌 宮頸癌前病變 人乳頭狀瘤病毒 基因分型　出處：《中國(guó)病原生物學(xué)雜志》2017年12期 　論文類(lèi)型：期刊論文

【摘要】：目的分析女性生殖道人乳頭狀瘤病毒(HPV)感染及其基因分型與宮頸癌的關(guān)系。方法納入宮頸癌及宮頸癌前病變患者共150例,其中宮頸癌患者63例(宮頸癌組),宮頸癌前病變患者87例(癌前病變組),另選宮頸炎患者50例作為對(duì)照組;分析各組患者HPV感染情況,并進(jìn)行HPV基因分型檢測(cè)。結(jié)果 200例宮頸疾病患者HPV總陽(yáng)性率為72.0%(144/200),其中宮頸癌組和癌前病變組HPV陽(yáng)性率分別為100.0%和67.8%,均顯著高于對(duì)照組(44.0%)(P0.05),且宮頸癌組HPV陽(yáng)性率明顯高于癌前病變組(P0.05);宮頸癌患者主要感染HPV16、18、33和58,CINⅠ患者主要感染HPV6、11、16、33、52和59,CINⅡ患者主要感染HPV6、11、16、31、33、52和58,CINⅢ患者主要感染HPV16、18、31、33、51和58,對(duì)照組患者主要感染HPV6、11、33、43、52、58、66及68;宮頸癌組和癌前病變組高危型HPV陽(yáng)性率(100.0%、77.3%)均顯著高于對(duì)照組(42.6%)(P0.05),且宮頸癌組高危型HPV陽(yáng)性百分比高于癌前病變組(P0.05);宮頸癌組、癌前病變組及對(duì)照組單一型HPV感染率分別為100.0%、81.4%和40.9%,多重型HPV感染率分別為0、18.6%和59.1%;HPV感染及高危型HPV感染均與宮頸癌的發(fā)生呈正相關(guān)(P0.05)。結(jié)論宮頸癌的發(fā)生與高危型HPV感染密切相關(guān),HPV基因分型檢測(cè)對(duì)宮頸癌前病變及宮頸癌的篩查、診斷及預(yù)防具有重要意義。
[Abstract]:Objective to analyze the relationship between human papillomavirus (HPV) infection in female genital tract and cervical cancer. Methods 150 patients with cervical cancer and cervical precancerous lesions were included. There were 63 patients with cervical carcinoma (cervical cancer group), 87 patients with cervical precancerous lesion (precancerous lesion group) and 50 patients with cervicitis as control group. Results the total positive rate of HPV in 200 patients with cervical diseases was 72.0 / 144 / 200). The positive rates of HPV in cervical cancer group and precancerous lesion group were 100.0% and 67.8 respectively, which were significantly higher than those in control group (P 0.05). The positive rate of HPV in cervical cancer group was significantly higher than that in precancerous lesion group (P 0.05). Patients with cervical cancer were mainly infected with HPV16CINI and HPV61116163C3M52 and 59 CINII patients were mainly infected with HPV6. Patients with CIN 鈪，

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