本文關(guān)鍵詞：復(fù)合三角型布針射頻消融術(shù)對離體牛肝擴大壞死區(qū)域的實驗研究　出處：《揚州大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 肝癌 射頻消融治療 實驗研究 復(fù)合三角形布針 離體牛肝 消融區(qū)

【摘要】：目的探討應(yīng)用雙極射頻電極通過三角形布針及復(fù)合三角形布針射頻消融技術(shù)(RFA)對離體牛肝消融壞死區(qū)容積及擴大壞死消融的可行性及有效性,并為臨床大腫瘤的擴大壞死性消融提供理論依據(jù)。方法采用Olympus celon雙極消融針及其主機對離體牛肝進行消融,射頻消融針的規(guī)格型號為T4.0,長度20cm,主機最大功率為250W/60Ω、470kHz、100-240V,50-60赫茲。1、三角形布針消融模式實驗1：T4.0射頻消融針、長度15cm,等距離三角形布針,針距3cm。實驗2：等距離三角形布針,針距4cm。實驗3：等距離三角形布針,針距5cm。2、復(fù)合三角形布針消融模式實驗4：復(fù)合三角形布針,在離體牛肝插入5根射頻針,使X、Y=6cm,在X、Y軸線上的3根射頻針距離相等為3cm,等腰三角形另一邊為4.2cm,根據(jù)消融順序分為A、B、C、D四個區(qū)域,消融范圍為A+B+C+D區(qū)域的疊加。實驗5：復(fù)合三角形布針,在離體牛肝插入5根射頻針,使X、Y=8,在X、Y軸線上的3根射頻針距離相等為4cm,等腰三角形另一邊為5.7cm,根據(jù)消融順序分為A、B、C、D四個區(qū)域,消融范圍為A+B+C+D區(qū)域的疊加。實驗6：復(fù)合三角形布針,創(chuàng)建6個消融區(qū),均為等邊三角形布針,針距4cm在離體牛肝插入7根射頻針,使X、Y=8,在X、Y軸線上的3根射頻針距離相等為4cm,等腰三角形另一邊為5.7cm,根據(jù)消融順序分為A、B、C、D四個區(qū)域,消融范圍為A+B+C+D+E+F區(qū)域的疊加。結(jié)果1、三角形布針消融模式實驗1：應(yīng)用Oiympus celonT4.0射頻針,等距離三角形布針,針距為3cm,可獲得毀損直徑分別為X=5cm,Y=5cm,Z=5cm,消融容積65.41 cm3。實驗2：等距離三角形布針,針距4cm。毀損直徑X=6cm,Y=6cm,Z=6cm,消融容積113.03cm3實驗3：等距離三角形布針,針距5cm,毀損直徑X=7cm,Y=5cm,Z=4cm,消融容積73.26cm32、復(fù)合三角形布針消融模式實驗4：復(fù)合三角形布針,在X和Y軸直徑=6cm創(chuàng)建4個三角形消融地區(qū),毀損直徑X=7cm,Y=7 cm,Z=5 cm,消融容積128.21 cm3。實驗5：復(fù)合三角形布針,4個三角形消融地區(qū),X、Y軸直徑為8cm,毀損直徑X=8cm,Y=8cm,Z=7 cm,消融容積234.45 cm3。實驗6：復(fù)合三角形布針,創(chuàng)建6個消融區(qū),毀損直徑X=9cm,Y=7cm,Z=7 cm,消融容積230.79 cm3。結(jié)論三角形布針消融模式,等距離布針,針距為3、4cm時,消融容積為球體,針距為4cm消融容積明顯大于針距為3cm時消融容積；針距5cm,消融容積為類球體僅稍大于針距為3cm的消融容積,但消融灶周邊融合不佳。復(fù)合三角形布針消融模式,4區(qū)消融模式X和Y軸直徑8cm的消融容積明顯大于直徑6cm消融容積。6區(qū)消融模式的消融容積稍小于4區(qū)消融模式X和Y軸直徑8cm的消融容積。應(yīng)用4區(qū)和6區(qū)消融模式可明顯的擴大消融范圍和消融容積,對于大腫瘤的完全消融提供了有力的理論依據(jù)；6區(qū)消融模式消融容積小于4區(qū)消融模式X和Y軸直徑8cm的消融容積,對于減少患者創(chuàng)傷和費用有重要的臨床意義。臨床消融模式的確定,要根據(jù)腫瘤的大小和形態(tài),采取不同的消融模式,X、Y軸針距,該設(shè)備應(yīng)不大于4cm。由于受肋間隙的影響,布針情況不可能達到實驗的理想狀態(tài)。
[Abstract]:Objective to investigate the application of bipolar radiofrequency electrode by triangular needle and needle cloth composite triangular radiofrequency ablation (RFA) on isolated bovine liver ablation necrosis volume and expand the feasibility and effectiveness of ablation and necrosis, to expand the clinical tumor necrotic ablation and provide a theoretical basis for the. Methods the Olympus celon bipolar ablation needle and its host were used to ablation the isolated bovine liver. The specification of the radiofrequency ablation needle is T4.0, and the length is 20cm. The maximum power of the host is 250W/60 ohm, 470kHz and 100-240V, and 50-60 Hz. 1. The triangle cloth needle ablation model experiment 1:T4.0 radiofrequency ablation needle, length 15cm, equal distance triangle cloth needle, needle distance 3cm. Experiment 2: the equal distance triangle cloth needle, the needle distance 4cm. Experiment 3: the equal distance triangle cloth needle, the needle distance 5cm. 2, composite triangular needle ablation model experiment 4: composite triangular needle, in vitro bovine liver inserted 5 RF needle, X, Y=6cm, 3 X, RF needle distance is equal in the Y axis is 3cm, an isosceles triangle on the other side of 4.2cm, according to the order of ablation is divided into A, B, C, D four regions, as the superposition of the A+B+C+D region of the ablation range. Experiment 5: composite triangular needle, in vitro bovine liver inserted 5 RF needle, X, Y=8, 3 X, RF needle distance is equal in the Y axis is 4cm, an isosceles triangle on the other side of 5.7cm, according to the order of ablation is divided into A, B, C, D four regions, ablation range of superposition of A+B+C+D region. Experiment 6: composite triangular needle, create 6 ablation zone, is an equilateral triangle cloth needle, needle distance 4cm in vitro bovine liver inserted 7 RF needle, X, Y=8, 3 X, RF needle distance is equal in the Y axis is 4cm, an isosceles triangle on the other side of 5.7cm, according to the ablation sequence is divided into A, B, C, D four, A+B+C+D+E+F area to overlay the ablation range. Results 1, triangle ablation mode experiment 1: using Oiympus celonT4.0 radiofrequency needle, equal distance triangular cloth needle and needle distance of 3cm, the diameter of damage can be X=5cm, Y=5cm, Z=5cm and ablation volume 65.41 cm3 respectively. Experiment 2: the equal distance triangle cloth needle, the needle distance 4cm. Damage to X=6cm in diameter, Y=6cm, Z=6cm, 113.03cm3 3: experimental ablation volume distance of triangular needle, needle distance 5cm, damage Y=5cm, diameter X=7cm, Z=4cm, 73.26cm32, composite volume ablation of triangular needle ablation model experiment 4: composite triangular needle, creating 4 triangles in the X and Y axis diameter =6cm ablation area. Damage to Y=7 cm, diameter X=7cm, Z=5 cm, the ablation volume 128.21 cm3. Experiment 5: Compound triangle needle, 4 triangle ablation area, X, Y axis diameter 8cm, damage diameter X=8cm, Y=8cm, Z=7 cm, ablation volume 234.45 cm3. Experiment 6: a compound triangle needle was used to create 6 ablation areas, which damaged the diameter X=9cm, Y=7cm, Z=7 cm, and the ablation volume was 230.79 cm3. Conclusion the triangular needle ablation mode, such as distance cloth needle, the needle distance is 3 4cm, when the ablation volume of sphere, needle distance of 4cm volume was significantly greater than the needle ablation distance of 3cm ablation volume; needle distance 5cm, ablation volume of a spheroid is only slightly larger than the needle distance of 3cm ablation volume, but ablation the surrounding poor integration. The ablation volume of the 4 zone ablation mode X and the Y axis diameter 8cm was significantly greater than the diameter of the diameter 6cm ablation. The ablation volume of the 6 area ablation mode was slightly smaller than that of the 4 zone ablation mode X and the Y axis diameter 8cm. Application of 4 zone and 6 zone ablation mode can significantly expand the scope of ablation and ablation volume, provides a strong theoretical basis for the complete ablation of large tumors; 6 ablation mode ablation volume less than 4 ablation mode X and Y axis diameter 8cm ablation volume for patients has important clinical significance to reduce trauma and cost. According to the size and shape of the tumor, we should take different ablation modes according to the size and shape of the tumor. The needle distance of X and Y axis should not be greater than 4cm. Because of the influence of the ribbed gap, the situation of the needle cloth can not reach the ideal state of the experiment.
【學(xué)位授予單位】：揚州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R735.7

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