【摘要】：目的:觀察中西醫(yī)結(jié)合治療原發(fā)性肝癌的臨床療效,分析各種因素對(duì)預(yù)后的影響,并探討參麥、欖香烯、復(fù)方苦參注射液對(duì)體外肝癌細(xì)胞轉(zhuǎn)移相關(guān)因子的影響。方法:統(tǒng)計(jì)山東中醫(yī)藥大學(xué)附屬醫(yī)院和山東省臨沂市中醫(yī)院2000年1月至2004年2月間資料完整的住院病人和部分門診病人,進(jìn)行統(tǒng)計(jì)學(xué)處理。用MTT法觀察三種中藥注射液對(duì)肝癌細(xì)胞BEL-7402體外殺傷作用,用流式細(xì)胞儀檢測(cè)對(duì)轉(zhuǎn)移相關(guān)因子CD44V6和nm23等表達(dá)的影響。結(jié)果:中西醫(yī)結(jié)合放化療組和中西醫(yī)結(jié)合保守治療組對(duì)原發(fā)性肝癌患者的半年和一年生存期無明顯差異;肝功能分級(jí)、門靜脈瘤栓形成、臨床分期、AFP和肝硬化對(duì)生存率及評(píng)價(jià)預(yù)后均有不同程度的影響和參考價(jià)值:三種中藥注射液均具不同程度的體外抑瘤作用,以欖香烯體外抑瘤作用最強(qiáng);并能明顯抑制促轉(zhuǎn)移因子CD44v6的表達(dá)、促進(jìn)抑轉(zhuǎn)移因子nm23的表達(dá),且三組之間比較差異顯著。結(jié)論:中西醫(yī)結(jié)合是原發(fā)性肝癌的有效治療方法,中藥可通過直接抑瘤和抗轉(zhuǎn)移而發(fā)揮綜合抗腫瘤作用。
[Abstract]:Objective: to observe the clinical effect of integrated traditional Chinese and western medicine in the treatment of primary liver cancer, to analyze the influence of various factors on the prognosis, and to explore the effect of Shenmai, elemene and compound Sophora flavescens injection on the factors related to the metastasis of hepatocellular carcinoma cells in vitro. Methods: the inpatients and some outpatients with complete data from January 2000 to February 2004 in the affiliated Hospital of Shandong University of traditional Chinese Medicine and Linyi City Hospital of traditional Chinese Medicine of Shandong Province were statistically analyzed. MTT assay was used to observe the killing effect of three kinds of traditional Chinese medicine injection on hepatoma cell line BEL-7402 in vitro. Flow cytometry was used to detect the expression of metastasis related factors (CD44V6 and nm23). Results: there was no significant difference in the survival time of patients with primary liver cancer between radiotherapy and chemotherapy group and conservative treatment group, liver function grade, portal vein thrombus formation, liver function grade, portal vein thrombosis formation, liver function grade, portal vein thrombosis formation, liver function grade, portal vein tumor thrombus formation, Clinical staging, AFP and cirrhosis had different influence on survival rate and evaluation of prognosis. Three kinds of traditional Chinese medicine injection all had different degree of tumor inhibition in vitro, and elemene had the strongest effect in vitro. It also inhibited the expression of CD44v6 and promoted the expression of nm23, and the difference was significant among the three groups. Conclusion: integrated traditional Chinese and western medicine is an effective treatment for primary liver cancer. Chinese medicine can play a comprehensive antitumor effect through direct tumor inhibition and metastasis.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2005
【分類號(hào)】：R735.7

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