本文選題：中醫(yī)藥 + AECOPD�。� 參考：《中華中醫(yī)藥學(xué)刊》2017年10期

【摘要】：目的:探討清肺活血中藥輔助舒利迭治療慢性阻塞性肺疾病急性加重期(AECOPD)痰瘀阻肺證臨床療效及對(duì)炎性細(xì)胞因子、NF-κB的影響。方法:研究對(duì)象選取醫(yī)院2015年2月—2017年2月收治AECOPD痰瘀阻肺證患者共100例,隨機(jī)分為對(duì)照組(50例)和觀察組(50例),分別給予舒利迭單用治療和在此基礎(chǔ)上加用清肺活血中藥輔助治療,比較兩組患者臨床療效,治療前后主要證候積分、肺功能指標(biāo)、血?dú)夥治鲋笜?biāo)、炎性細(xì)胞因子及NF-κB水平等。結(jié)果:觀察組患者治療總有效率顯著高于對(duì)照組(P0.05);觀察組患者治療后主要證候積分顯著低于對(duì)照組、治療前(P0.05);觀察組患者治療后FEV1預(yù)計(jì)值、FEV1/FVC、PaO_2、PaCO_2及SaO_2水平均顯著優(yōu)于對(duì)照組、治療前(P0.05);觀察組患兒治療后hs-CRP、IL-10、TNF-α及NF-κB水平均顯著優(yōu)于對(duì)照組、治療前(P0.05)。結(jié)論:清肺活血中藥輔助舒利迭治療AECOPD痰瘀阻肺證可有效減輕相關(guān)癥狀體征,提高肺部通氣功能,改善動(dòng)脈血?dú)庵笜?biāo),抑制機(jī)體炎癥反應(yīng),并有助于調(diào)節(jié)NF-κB水平。
[Abstract]:Objective: to investigate the clinical effect of Qingfei Huoxue traditional Chinese medicine (TCM) for treating chronic obstructive pulmonary disease (COPD) with acute exacerbation of chronic obstructive pulmonary disease (COPD) with phlegm and stasis and its effect on inflammatory cytokine NF- 魏 B. Methods: from February 2015 to February 2017, 100 patients with AECOPD syndrome of phlegm and stasis were selected. Two groups were randomly divided into two groups: control group (n = 50) and observation group (n = 50). The patients in the observation group were treated with sulidil alone and supplemented with traditional Chinese medicine for clearing the lung and activating blood on this basis. The clinical efficacy, the main syndromes integral, the pulmonary function index before and after treatment were compared between the two groups. Blood gas analysis, inflammatory cytokines and NF- 魏 B levels. Results: the total effective rate of treatment in the observation group was significantly higher than that in the control group (P 0.05), the score of the main syndromes in the observation group was significantly lower than that in the control group (P 0.05), the predicted value of FEV1 in the observation group was significantly higher than that in the control group (P < 0.05), and the predicted value of FEV1 in the observation group was significantly higher than that in the control group (P < 0.05). The levels of hs-CRPnIL-10 TNF- 偽 and NF- 魏 B in the observation group were significantly higher than those in the control group (P 0.05). Conclusion: Chinese herbal medicine for clearing lung and activating blood circulation can effectively relieve the symptoms and signs of phlegm stasis in AECOPD, improve pulmonary ventilation function, improve arterial blood gas index, inhibit inflammatory reaction, and help to regulate the level of NF- 魏 B.
【作者單位】： 青島市海慈醫(yī)療集團(tuán)肺病科;
【基金】：青島市公共領(lǐng)域科技支撐計(jì)劃項(xiàng)目[11-2-3-4(4)-nsh]
【分類號(hào)】：R563.9
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本文編號(hào)：1898255