本文關(guān)鍵詞： 坐位下體負(fù)壓 大腦中動脈血流速度 G致意識喪失 血氧飽和度 事件相關(guān)電位 反應(yīng)時(shí) 跟蹤誤差 正確率 心率 血壓　出處：《第四軍醫(yī)大學(xué)》2002年碩士論文　論文類型：學(xué)位論文

【摘要】： 飛行中飛行員可能暴露于+Gz環(huán)境下，+Gz負(fù)荷引起腦血流量減少到臨界值時(shí)，所發(fā)生的意識突然喪失的狀態(tài)稱為G致意識喪失(G-LOC)。近年來，隨著高性能戰(zhàn)斗機(jī)的發(fā)展，高G值(＞9G)，快增長率(＞6G/s)的持續(xù)性正加速度的醫(yī)學(xué)防護(hù)，特別是高過載致空中意識喪失的預(yù)防和監(jiān)控，對降低G-LOC的發(fā)生率，預(yù)防飛行事故的發(fā)生，提高飛行部隊(duì)的戰(zhàn)斗力，仍是航空航天醫(yī)學(xué)研究的重要課題之一。 下體負(fù)壓(LBNP)是模擬重力-慣性力場對人體循環(huán)功能影響的有效研究方法之一，在一定程度上可模擬正加速度對人體的影響。鑒于未來高技術(shù)戰(zhàn)爭的需要和飛行部隊(duì)的實(shí)際，有必要探討下體負(fù)壓對人體腦血流和腦認(rèn)知功能的影響，以此作為檢測G-LOC的手段和方法。 本實(shí)驗(yàn)的目的在于：1)觀察坐位下體負(fù)壓條件下人體大腦中動脈血流速度及耳部血氧飽和度的變化；2)探討坐位下體負(fù)壓對人體腦事件相關(guān)電 第四草醫(yī)大學(xué)碩士學(xué)位論文 一 位爬RPX 反應(yīng)時(shí)（RTX跟蹤誤差oR）等大腦認(rèn)知功能的影響，為空中暈厥和 立位耐力不良的醫(yī)學(xué)鑒定提供人體實(shí)驗(yàn)依據(jù)。 本研究選取13叫 名青年男性作為被試者。每名被試者均要在兩種坐 位下體負(fù)壓條件下各進(jìn)行兩個(gè)實(shí)驗(yàn)。兩種負(fù)壓條件分別為：t．00 kPa（－30 InmHg）和－6．67 kPa（50 mlnHg卜每個(gè)實(shí)驗(yàn)要在每種負(fù)壓條件下各測試 5 min，以負(fù)壓前 5 min測試的指標(biāo)作為對照。 實(shí)驗(yàn)一，15名被試者，主要觀察坐位下體負(fù)壓條件下對人體大腦中動 脈血流速度（V。c。L血氧飽和度（SaO＊和心率（HR）的影響。 實(shí)驗(yàn)二，13名被試者，主要觀察坐位下體負(fù)壓條件下視覺 Oddball模 式誘發(fā)的腦事件相關(guān)電位、雙任務(wù)反應(yīng)時(shí)、正確率aR郴跟蹤誤差的變化c 同時(shí)進(jìn)行血壓（BP）和心率的檢測。 兩個(gè)實(shí)驗(yàn)均記錄被試者的主觀癥狀和客觀體征。其上要實(shí)驗(yàn)結(jié)果如下： 1．坐位下體負(fù)壓對人體大腦中動脈血流速度、心率和血氧飽和度的影 響。在－4．00 kPa下體負(fù)壓作用4、5 min時(shí)，腦血流速度減慢（尸＜0．05）；負(fù) 壓作用3、4、smln時(shí)。0率增快滬＜o(jì)5）；血氧飽和度無明顯改變。在巧石7 Wa下體負(fù)壓作用2、3 min時(shí)，腦血流速度減慢什＜幾05） 在4和5 min時(shí) 顯著減慢o＜0．of），卸壓后 lmin尚未恢復(fù)，隨后恢復(fù)至對照水平；負(fù)壓作 用后各時(shí)間點(diǎn)。乙率均顯著增快滬叩刀1＼ 血氧飽和度在負(fù)k暴露5加D時(shí)明 顯下降（尸＜0刀5）。 2．坐位下體負(fù)壓對腦認(rèn)知工效及心血管功能的影響。在4刀0 kPa下 體負(fù)壓作用時(shí)，Psoo波幅（AMP）、Psoo潛時(shí)（LAT）、雙任務(wù)反應(yīng)時(shí)、跟蹤 誤差、血壓與負(fù)壓前對照無明顯差別：心率在下體負(fù)壓作用3、4、5叫n 時(shí)，顯著增快什＜0刀5卜在6石7wa下體負(fù)壓作用時(shí)，馬皿波幅顯著降低 （＜0．05），p300潛時(shí)顯著延長（p＜0．05）；反應(yīng)時(shí)延長（＜0．05），足蹤誤差增大 滬刃仍）：心率在負(fù)壓作用各時(shí)問點(diǎn)與負(fù)壓作用前比較均顯著增快什＜o(jì)01）； ．二l－ 第四罕醫(yī)大學(xué)碩士學(xué)位論文 一 收縮壓與負(fù)壓前對照無明顯改變，舒張壓顯著升高（P＜0．05）。 實(shí)驗(yàn)結(jié)果表明，坐位下體負(fù)壓造成大腦中動脈血流速度減慢，引起大 腦供血量減少，血液在下肢積聚，大腦對外界刺激的反應(yīng)減慢，腦認(rèn)知工 效下降，同時(shí)心血管部分代償功能加強(qiáng)，心率增快，，血壓升高，為空中暈 厥和立位耐力不良的醫(yī)學(xué)鑒定提供了人體實(shí)驗(yàn)依據(jù)。
[Abstract]:The pilot in flight may be exposed to the +Gz environment, +Gz load caused by cerebral blood flow is reduced to a critical value, the sudden loss of consciousness state called G induced loss of consciousness (G-LOC). In recent years, with the development of high performance fighter, high G value (> 9G), fast growth rate (> 6G/s) medical protection sustained positive acceleration, especially high overload caused by the prevention and monitor of unconsciousness, to reduce the incidence of G-LOC, prevention of flight accidents, improve flight fighting force, is still an important subject of aerospace medicine.
Lower body negative pressure (LBNP) is one of the gravity and inertia force field effect on the human body circulatory function effective simulation method, which can simulate the effects of acceleration on the human body to a certain extent. In view of the actual needs of the future high-tech war and flying units, it is necessary to study the effect of lower body negative pressure on blood flow and cognitive function of human brain and as a means and method for detection of G-LOC.
The purpose of this experiment is: 1) to observe the changes of blood flow velocity and blood oxygen saturation of human middle cerebral artery under the condition of sitting lower body negative pressure; 2) to explore the relative electrical activity of the body under the seat negative pressure.
Fourth master's degree thesis
One
The effects of the cognitive function of the brain, such as the RPX response (RTX tracking error oR), for syncope in the air and in the air.
The medical identification of the poor orthostatic tolerance provides the basis for the human experiment.
This study selected 13 young men called as subjects. All subjects were sitting in two
The two experimental conditions. A lower body negative pressure of two kinds of negative pressure conditions were: t.00 kPa (30
InmHg) and - 6.67 kPa (50 mlnHg divination experiments each test 5 under each negative pressure condition
Min, the index of the 5 min test before negative pressure was used as the control.
Experiment 1, 15 subjects, mainly observe the motion of the body's brain under the lower body negative pressure of the seat.
The effect of blood flow velocity (V.c.L oxygen saturation (SaO * and heart rate (HR)) on the blood flow velocity (HR).
Experiment two, 13 subjects, mainly observe the visual Oddball model under the negative pressure of the sitting position.
Type of brain evoked event-related potentials, dual task reaction time changes, the correct rate of aR Chenzhou tracking error C
At the same time, blood pressure (BP) and heart rate were tested.
The subjective symptoms and objective signs of the subjects were recorded in the two experiments. The results of the experiment were as follows:
The effect of 1. seat lower body negative pressure on the blood flow velocity, heart rate and oxygen saturation of the middle cerebral artery in the human body
Ring. In kPa 4,5 min 4.00 LBNP, cerebral blood flow velocity (P < 0.05); negative
The pressure of 3,4 and smln increase the.0 rate in Shanghai < O5 >; the blood oxygen saturation has no obvious change. In Qiao 7
When the lower body negative pressure of Wa is 2,3 min, the velocity of cerebral blood flow slows down more than 05) at 4 and 5 min
O < 0.of was significantly slowed down, and lmin was not restored after pressure relief, and then recovered to the control level; negative pressure was used.
After each time point. B were significantly increased at 1, Shanghai knife 5 plus D exposure to oxygen saturation in the negative K Ming
Declines (corpse < 0 knife 5).
The effect of lower body negative pressure on brain cognitive ergonomics and cardiovascular function in 2. sitting position under 4 knife and 0 kPa
When body negative pressure, Psoo amplitude (AMP), Psoo latent time (LAT), double task reaction, tracking
There is no significant difference between the blood pressure and the negative pressure before the negative pressure: the heart rate in the lower body negative pressure 3,4,5 is called n
At the time, the amplitude of the horse dish decreased significantly when the 0 knife and 5 divination was under the negative pressure of the 6 stone 7wa.
(< 0.05), the latent time of P300 was prolonged significantly (P < 0.05); the reaction time was prolonged (< 0.05) and the foot and trace error increased
The rate of heart rate in negative pressure was significantly higher than that before negative pressure.
Two L -
Fourth rare Medical University Master's degree thesis
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There was no significant change in the systolic pressure and the control before the negative pressure, and the diastolic pressure increased significantly (P < 0.05).
The experimental results show that the lower body pressure of the sitting position causes the decrease of the velocity of the middle cerebral artery in the cerebral artery.
A decrease in the amount of brain blood supply, the accumulation of blood in the lower extremities, the slowing of the brain's response to external stimuli, and the cognitive work of the brain
At the same time, the compensatory function of the cardiovascular part is strengthened, the heart rate is faster, the blood pressure is raised, and the air halo is in the air.
The medical identification of bad syncope and erect stamina provides the basis for human experiment.

【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2002
【分類號】：R852

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 許濤;莫達(dá)非尼對抗睡眠剝奪應(yīng)激效果的實(shí)驗(yàn)研究[D];第四軍醫(yī)大學(xué);2007年

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