焦爐作業(yè)工人尿中多環(huán)芳烴代謝物與肺功能下降的關(guān)聯(lián)性研究
發(fā)布時間：2019-06-27 13:37
【摘要】：目的：研究焦爐作業(yè)工人尿中多環(huán)芳烴（polycyclic aromatic hydrocarbons，PAHs）代謝物與肺功能下降的關(guān)聯(lián)，為進一步闡明焦爐工人早期肺部損傷機制以及制訂預(yù)防職業(yè)性肺損傷的策略提供科學(xué)依據(jù)。 方法：檢測環(huán)境中一氧化碳、二氧化硫、苯可溶物、顆粒物及顆粒物上載帶PAHs的濃度，采用問卷調(diào)查和健康體檢的方式收集武漢某焦化廠912名工人的職業(yè)信息和健康情況，工人按照外環(huán)境檢測結(jié)果和職業(yè)史分為辦公室人群（對照組）和焦爐作業(yè)工人（暴露組）。收集工人的清晨尿液，用氣相色譜-質(zhì)譜聯(lián)用儀檢測尿中10種PAHs代謝物，并采用肺功能分析儀檢測工人的肺功能。 結(jié)果：焦爐作業(yè)工人長期暴露于高濃度的COEs中，而辦公室區(qū)域的COEs水平相對較低，據(jù)此，我們將焦爐作業(yè)人群定義為暴露組，辦公人群定義為對照組。盡管暴露組的平均年齡和工齡均小于對照組，但其肺功能均低于對照組，差異有統(tǒng)計學(xué)意義。接著，，我們根據(jù)工人的職業(yè)史，計算了工人在焦爐作業(yè)的時間，即焦爐作業(yè)時間，沒有在焦爐工作的時間即為無焦爐作業(yè)時間。結(jié)果顯示，在暴露組中，腰臀比與FEV1%的負關(guān)聯(lián)有顯著性，并且隨焦爐作業(yè)時間的增加，F(xiàn)EV1/FVC%降低的趨勢也具有顯著性（β=㧟0.156）。在對照組中，F(xiàn)EV1%和FEV1/FVC%與年齡和吸煙包年的關(guān)聯(lián)有顯著性差異。然后，我們討論了尿中PAHs代謝物與肺功能的關(guān)聯(lián)，將暴露組PAHs代謝產(chǎn)物的蓄積作用定義為PAHs代謝物濃度與焦爐作業(yè)時間的乘積，對照組PAHs代謝物的蓄積作用定義為PAHs代謝物濃度與無焦爐作業(yè)時間的乘積。在暴露組中，OHPh和1-OHP的蓄積作用均顯示和FEV1/FVC%的負關(guān)聯(lián)具有顯著性差異（β=㧟0.136，β=㧟0.100），并且OHPh和1-OHP相加作用的蓄積作用也顯示和FEV1/FVC%呈負關(guān)聯(lián)（β=㧟0.127），P值均小于0.05，而在對照組中，PAHs代謝物的蓄積作用均無統(tǒng)計學(xué)意義。 結(jié)論：焦爐作業(yè)工人尿中PAHs代謝物與肺功能下降相關(guān)聯(lián)，提示長期暴露于職業(yè)性PAHs引起工人肺部早期損傷，并且PAHs中的菲和芘有可能是引起焦爐工肺部早期損傷的主要物質(zhì)。
[Abstract]:Objective: to study the relationship between urinary polycyclic aromatic hydrocarbons (polycyclic aromatic hydrocarbons,PAHs) metabolites and decreased lung function in coke oven workers, and to provide scientific basis for further elucidating the mechanism of early lung injury in coke oven workers and formulating strategies to prevent occupational lung injury. Methods: the concentrations of carbon monoxide, sulfur dioxide, benzene soluble matter, particulate matter and particulate matter carrying PAHs in the environment were measured. The occupational information and health status of 912 workers in a coking plant in Wuhan were collected by questionnaire and physical examination. According to the results of external environment test and occupational history, the workers were divided into office population (control group) and coke oven workers (exposure group). The early morning urine of workers was collected, 10 kinds of PAHs metabolites in urine were detected by gas chromatography-mass spectrometry (GC-MS), and the pulmonary function of workers was detected by pulmonary function analyzer. Results: coke oven workers were exposed to high concentration of COEs for a long time, but the COEs level in office area was relatively low. According to this, we defined coke oven workers as exposure group and office population as control group. Although the average age and length of service of the exposed group were lower than those of the control group, the pulmonary function of the exposed group was lower than that of the control group, and the difference was statistically significant. Then, according to the occupational history of the workers, we calculate the working time of the workers in the coke oven, that is, the working time of the coke oven, and the time of not working in the coke oven is the time without the coke oven. The results showed that there was a significant negative correlation between waist hip ratio and FEV1% in the exposed group, and the decrease trend of FEV1/FVC% was also significant with the increase of coke oven operation time (尾 = 0.156). In the control group, there were significant differences between FEV1% and FEV1/FVC% and age and smoking age. Then, we discussed the relationship between PAHs metabolites in urine and lung function. The accumulation of PAHs metabolites in exposure group was defined as the product of PAHs metabolite concentration and coke oven operation time, and the accumulation of PAHs metabolites in control group was defined as the product of PAHs metabolite concentration and coke oven operation time. In the exposure group, the accumulation of OHPh and 1-OHP was significantly different from that of FEV1/FVC% (尾 = 0.136, 尾 = 0.100), and the accumulation of OHPh and 1-OHP was negatively correlated with FEV1/FVC% (尾 = 0.127), P value was less than 0.05, but there was no significant difference in the accumulation of PAHs metabolites in the control group. Conclusion: PAHs metabolites in urine of coke oven workers are associated with decreased lung function, suggesting that long-term exposure to occupational PAHs may cause early lung injury in workers, and phenanthrene and pyrene in PAHs may be the main substances causing early lung injury in coke oven workers.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R131
本文編號：2506838
[Abstract]:Objective: to study the relationship between urinary polycyclic aromatic hydrocarbons (polycyclic aromatic hydrocarbons,PAHs) metabolites and decreased lung function in coke oven workers, and to provide scientific basis for further elucidating the mechanism of early lung injury in coke oven workers and formulating strategies to prevent occupational lung injury. Methods: the concentrations of carbon monoxide, sulfur dioxide, benzene soluble matter, particulate matter and particulate matter carrying PAHs in the environment were measured. The occupational information and health status of 912 workers in a coking plant in Wuhan were collected by questionnaire and physical examination. According to the results of external environment test and occupational history, the workers were divided into office population (control group) and coke oven workers (exposure group). The early morning urine of workers was collected, 10 kinds of PAHs metabolites in urine were detected by gas chromatography-mass spectrometry (GC-MS), and the pulmonary function of workers was detected by pulmonary function analyzer. Results: coke oven workers were exposed to high concentration of COEs for a long time, but the COEs level in office area was relatively low. According to this, we defined coke oven workers as exposure group and office population as control group. Although the average age and length of service of the exposed group were lower than those of the control group, the pulmonary function of the exposed group was lower than that of the control group, and the difference was statistically significant. Then, according to the occupational history of the workers, we calculate the working time of the workers in the coke oven, that is, the working time of the coke oven, and the time of not working in the coke oven is the time without the coke oven. The results showed that there was a significant negative correlation between waist hip ratio and FEV1% in the exposed group, and the decrease trend of FEV1/FVC% was also significant with the increase of coke oven operation time (尾 = 0.156). In the control group, there were significant differences between FEV1% and FEV1/FVC% and age and smoking age. Then, we discussed the relationship between PAHs metabolites in urine and lung function. The accumulation of PAHs metabolites in exposure group was defined as the product of PAHs metabolite concentration and coke oven operation time, and the accumulation of PAHs metabolites in control group was defined as the product of PAHs metabolite concentration and coke oven operation time. In the exposure group, the accumulation of OHPh and 1-OHP was significantly different from that of FEV1/FVC% (尾 = 0.136, 尾 = 0.100), and the accumulation of OHPh and 1-OHP was negatively correlated with FEV1/FVC% (尾 = 0.127), P value was less than 0.05, but there was no significant difference in the accumulation of PAHs metabolites in the control group. Conclusion: PAHs metabolites in urine of coke oven workers are associated with decreased lung function, suggesting that long-term exposure to occupational PAHs may cause early lung injury in workers, and phenanthrene and pyrene in PAHs may be the main substances causing early lung injury in coke oven workers.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R131
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本文編號：2506838
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