發(fā)布時(shí)間：2019-05-08 12:27

【摘要】：目的探索肌酐校正的尿碘指標(biāo)估計(jì)尿碘排出量的準(zhǔn)確性。方法在山東省德州市寧津縣和陵縣選取6所小學(xué),間隔3w兩次收集3~6年級(jí)全部?jī)和囊淮涡噪S機(jī)尿和24h尿。量取24h尿液體積,檢測(cè)尿碘和肌酐濃度。計(jì)算得到實(shí)際24h尿碘排出量,而估計(jì)24h尿碘排出量則通過(guò)一次性隨機(jī)尿尿碘肌酐的濃度比值乘以24h肌酐排出量得到。結(jié)果比較兩次重復(fù)采樣,隨機(jī)尿的尿碘肌酐比值、24h尿碘濃度和24h尿碘排出量未見(jiàn)統(tǒng)計(jì)學(xué)差異(P0.05)。但是在每次采樣中,估計(jì)24h尿碘排出量顯著低于實(shí)際24h尿碘排出量(P0.001)。此外,在兩次重復(fù)采樣中,隨機(jī)尿碘濃度(r_s=0.585,P0.001;r_s=0.570,P0.001),隨機(jī)尿尿碘肌酐比值(r_s=0.620,P0.001;r_s=0.612,P0.001),估計(jì)24h尿碘排出量(r_s=0.843,P0.001;r_s=0.845,P0.001)分別與實(shí)際24h尿碘排出量呈良好線性關(guān)系。結(jié)論在學(xué)齡兒童中,由肌酐校正的一次性隨機(jī)尿估計(jì)出的24h尿碘排出量,可以作為評(píng)價(jià)個(gè)體碘攝入量的有效指標(biāo)。今后的研究有必要建立學(xué)齡兒童尿肌酐日排出量的標(biāo)準(zhǔn)。
[Abstract]:Objective to explore the accuracy of urinary iodine excretion estimated by creatinine correction. Methods six primary schools were selected from Ningjin County and Lingxian County of Dezhou City, Shandong Province. Random urine and 24-hour urine were collected from all children of grade 3 / 6 at 3 weeks interval. 24 h urine volume was measured and urinary iodine and creatinine concentrations were measured. The actual 24-hour urinary iodine excretion was calculated, and the estimated 24-hour urinary iodine excretion was calculated by multiplying the concentration ratio of 24-hour urine iodine to 24-hour urine creatinine by multiplying the 24-hour urinary iodine excretion. Results there was no significant difference in urine iodine-creatinine ratio, 24-hour urinary iodine concentration and 24-hour urinary iodine excretion between two repeated samples (P0.05). However, in each sampling, the estimated 24-hour urinary iodine excretion was significantly lower than the actual 24-hour urinary iodine excretion (P0.001). In addition, the random urinary iodine concentration (r = 0.585, P 0.001 / r = 0.570, P0.001) and the ratio of urine iodine / creatinine (r = 0.620, P0.001) were also observed in two repeated sampling cases (r = 0. 585, P = 0. 001, P < 0. 001). There was a good linear relationship between the estimated 24-hour urinary iodine excretion and the actual 24-hour urinary iodine excretion (r = 0.843, P 0.001 / r = 0.845, P 0.001), and there was a good linear relationship between the estimated 24-hour urinary iodine excretion and the actual 24-hour urinary iodine excretion (r = 0.843, P 0.001 / r = 0.845, P 0.001). Conclusion in school-age children, the 24-hour urinary iodine excretion estimated by one-time random urine adjusted by creatinine can be used as an effective index to evaluate the individual iodine intake. In future studies, it is necessary to establish a standard for daily urinary creatinine excretion in school-age children.
【作者單位】： 天津醫(yī)科大學(xué)公共衛(wèi)生學(xué)院;天津醫(yī)科大學(xué)內(nèi)分泌研究所;
【基金】：國(guó)家自然科學(xué)基金(No.81273057;81330064)
【分類(lèi)號(hào)】：R153.2

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