【摘要】：為探討吸入大氣PM2.5的大鼠海馬組織和全血中鉛、鋁、錳含量變化及血清和海馬中神經(jīng)遞質(zhì)一氧化氮(NO)和一氧化氮合酶(NOS)的變化,將SPF級雄性大鼠32只隨機(jī)分為對照組、PM2.5低劑量組(5 mg/kg)、PM2.5中劑量組(10 mg/kg)、PM2.5高劑量組(20 mg/kg),每組8只,經(jīng)氣管注入PM2.5混懸液,每周1次,連續(xù)12周。測定大腦海馬組織和全血中鉛、鋁、錳含量及血清、海馬中NO含量和NOS活力。結(jié)果顯示,隨著染毒劑量的增加,大鼠海馬中鉛含量逐漸升高,中、高劑量組海馬中錳含量和高劑量組海馬中鋁含量高于對照組,高劑量組血清NO含量和各染毒組海馬組織中NO含量低于對照組,高劑量組海馬組織中NOS活力低于對照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。提示PM2.5可使大鼠海馬中鉛、鋁、錳含量升高,海馬NO含量和NOS活力降低。
[Abstract]:To investigate the changes of lead, aluminum and manganese contents in hippocampus and whole blood and the changes of nitric oxide (NO) and nitric oxide synthase (NOS) in serum and hippocampus of rats inhaled with atmospheric PM2.5. Thirty-two male SPF rats were randomly divided into control group, PM2.5 low dose group (5 mg/kg), PM2.5 medium dose group (10 mg/kg), PM2.5 high dose group (20 mg/kg), 8 rats in each group. PM2.5 suspension was injected via trachea. Once a week for 12 consecutive weeks. The contents of lead, aluminum and manganese in hippocampus and whole blood, the content of NO and the activity of NOS in serum and hippocampus were measured. The results showed that the content of lead in hippocampus of rats increased gradually with the increase of exposure dose. The content of manganese in hippocampus of middle and high dose group and aluminum content of hippocampus of high dose group were higher than those of control group. The content of serum NO and the content of NO in hippocampus of the high-dose group were lower than those of the control group, and the activity of NOS in the high-dose group was lower than that of the control group, the difference was statistically significant (P0.05). It was suggested that PM2.5 could increase the contents of lead, aluminum and manganese in the hippocampus of rats, and decrease the content of NO and the activity of NOS in the hippocampus of rats.
【作者單位】： 唐山市環(huán)境監(jiān)測中心站大氣監(jiān)測室;河北聯(lián)合大學(xué)公共衛(wèi)生學(xué)院;
【分類號】：R114

【參考文獻(xiàn)】

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1 於方;過孝民;張衍q，

本文編號：2455657