【摘要】：環(huán)境污染風(fēng)險(xiǎn)評(píng)估中混合物毒性是一個(gè)重要的問(wèn)題,大量數(shù)據(jù)可為環(huán)境健康效應(yīng)評(píng)估提供材料。然而,在現(xiàn)有的技術(shù)方面要解釋復(fù)合物的相互作用還是很困難的。重金屬和有機(jī)磷農(nóng)藥污染對(duì)人類(lèi)有潛在的健康風(fēng)險(xiǎn)。盡管先前的研究證實(shí)鎘(Cd)和毒死蜱(CPF)在環(huán)境介質(zhì)和食物鏈中是共存的,但是它們之間的相互作用和潛在的復(fù)合毒性機(jī)制還很不清楚。本研究采用TLC和1H NMR來(lái)研究鎘離子和毒死蜱的相互作用而誘導(dǎo)的肝臟毒性。本研究發(fā)現(xiàn)Cd2+和CPF之間可以發(fā)生一種新的相互作用,可能是Cd2+結(jié)合在CPF的吡啶環(huán)上,也有可能是一個(gè)Cd2+螯合兩個(gè)CPF分子。鎘與毒死蜱形成的復(fù)合物毒性明顯高于它們單獨(dú)時(shí)候的毒性,對(duì)毒死蜱與鎘復(fù)合暴露后進(jìn)行研究發(fā)現(xiàn)其胞內(nèi)產(chǎn)生明顯的氧化損傷效應(yīng)。利用核磁共振技術(shù)探討兩類(lèi)污染物間的相互關(guān)系,發(fā)現(xiàn)兩者很有可能形成一種穩(wěn)定的螯合物存在于環(huán)境中,并且比單獨(dú)存在時(shí)有更強(qiáng)的毒性,對(duì)環(huán)境造成更嚴(yán)重的危害。 癌癥是現(xiàn)代社會(huì)廣泛關(guān)注的人類(lèi)第二大高死亡率的疾病,現(xiàn)階段常規(guī)手段的治療主要有化療放療等生物化學(xué)手段,或者是手術(shù)方法。而這些治療手段由于科學(xué)技術(shù)方面的限制,會(huì)對(duì)人類(lèi)健康產(chǎn)生很多副作用。因此,新穎的抗癌療法急需去改善癌癥臨床治療并減少副作用。納米科技和納米材料的快速應(yīng)用對(duì)于抗癌治療中起重要作用。然而,怎么去把新的納米技術(shù)和納米材料應(yīng)用到癌癥的治療中還有待研究。在本研究中,我們通過(guò)實(shí)驗(yàn)發(fā)現(xiàn)在宮頸癌細(xì)胞中量子點(diǎn)可以通過(guò)抑制ROCK的活性抑制ROCK-c-Myc信號(hào)通路從而抑制宮頸癌的發(fā)生發(fā)展。
[Abstract]:Toxicity of mixtures is an important problem in environmental pollution risk assessment, and a large amount of data can be used to assess environmental health effects. However, it is difficult to explain the interaction of the complex in existing techniques. Pollution of heavy metals and organophosphorus pesticides has potential health risks to human beings. Although previous studies have confirmed that cadmium (Cd) and chlorpyrifos (CPF) coexist in environmental media and food chain, the interaction between them and the underlying mechanism of compound toxicity are still unclear. In this study, TLC and 1H NMR were used to study the hepatotoxicity induced by the interaction of cadmium and chlorpyrifos. In this study, we found that a new interaction can occur between Cd2 and CPF. It may be that Cd2 binds to the pyridine ring of CPF or that one Cd2 chelates two CPF molecules. The toxicity of the complex formed by cadmium and chlorpyrifos was higher than that of chlorpyrifos alone. Nuclear magnetic resonance (NMR) was used to study the relationship between the two kinds of pollutants. It was found that a stable chelate exists in the environment, which is more toxic and more serious to the environment than when it exists alone. Cancer is the second highest mortality disease in modern society. At present, the conventional treatment mainly includes chemotherapy, radiotherapy and other biochemical methods, or surgical methods. These treatments, due to scientific and technological constraints, can have many side effects on human health. Therefore, novel anti-cancer therapies urgently need to improve the clinical treatment of cancer and reduce side effects. The rapid application of nanotechnology and nanomaterials plays an important role in anticancer therapy. However, how to apply new nanotechnology and nanomaterials to cancer treatment remains to be studied. In this study, we found that in cervical cancer cells, quantum dots can inhibit the development of cervical cancer by inhibiting the activity of ROCK and inhibiting the ROCK-c-Myc signaling pathway.
【學(xué)位授予單位】：山西大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類(lèi)號(hào)】：R114

【共引文獻(xiàn)】

相關(guān)期刊論文 前3條

1 ;Spatial and temporal distribution of acetochlor in sediments and riparian soils of the Songhua River Basin in northeastern China[J];Journal of Environmental Sciences;2011年10期

2 曹s，

本文編號(hào)：2374801