微乳碘的抗菌效果及安全性評價
發(fā)布時間：2018-09-03 11:31
【摘要】：目的對自制微乳碘的殺菌效果和安全性進行考察與評價。方法通過最小抑菌濃度(MIC)和最小殺菌濃度(MBC)試驗、抑菌率和殺菌率試驗評價自制微乳碘的抗菌效果;通過受試動物皮膚刺激性試驗和皮內(nèi)刺激性試驗對自制微乳碘的安全性進行考察與評價。結(jié)果自制微乳碘對金黃色葡萄球菌、銅綠假單胞菌的MIC為11.72 mg/L,對白色念珠菌和大腸桿菌的MIC為23.44 mg/L;4種菌的MBC不大于94.0 mg/L;有效碘含量在12.0~90.0 mg/L范圍,于2 min內(nèi)對4種菌的抑菌率、殺菌率均達100%。有效碘含量為1 500 mg/L時對家兔完整皮膚、破損皮膚及皮內(nèi)均無刺激性反應(yīng)。結(jié)論與該市售碘伏比較,自制微乳碘具有使用安全、起效快、起效濃度低、殺菌效果好等特點,可為臨床消毒提供一種新的手段。
[Abstract]:Objective to investigate and evaluate the bactericidal efficacy and safety of self-made microemulsion iodine. Methods the antibacterial effect of self-made microemulsion iodine was evaluated by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) test, bacteriostatic rate and bactericidal rate test. The safety of self-made microemulsion iodine was investigated and evaluated by skin irritation test and intradermal irritation test. Results the MIC of microemulsion iodine to Staphylococcus aureus, Pseudomonas aeruginosa was 11.72 mg/L, to Candida albicans and MIC of Escherichia coli was 23.44 mg/L;4, the MBC of microemulsion iodine to Staphylococcus aureus was less than 94.0 mg/L; and the effective iodine content was 12.0 ~ 90.0 mg/L, and the inhibition rate of 4 strains was within 2 min. The bactericidal rate is 100%. When the effective iodine content was 1 500 mg/L, there was no irritation to the intact skin, damaged skin and skin. Conclusion compared with the iodophor sold in the city, the self-made microemulsion iodine has the characteristics of safe use, quick onset, low initial concentration and good bactericidal effect, which can provide a new method for clinical disinfection.
【作者單位】： 山西醫(yī)科大學藥學院;山西大醫(yī)院;
【基金】：山西省重點學科建設(shè)經(jīng)費資助(2016)
【分類號】：R187.1
本文編號：2219853
[Abstract]:Objective to investigate and evaluate the bactericidal efficacy and safety of self-made microemulsion iodine. Methods the antibacterial effect of self-made microemulsion iodine was evaluated by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) test, bacteriostatic rate and bactericidal rate test. The safety of self-made microemulsion iodine was investigated and evaluated by skin irritation test and intradermal irritation test. Results the MIC of microemulsion iodine to Staphylococcus aureus, Pseudomonas aeruginosa was 11.72 mg/L, to Candida albicans and MIC of Escherichia coli was 23.44 mg/L;4, the MBC of microemulsion iodine to Staphylococcus aureus was less than 94.0 mg/L; and the effective iodine content was 12.0 ~ 90.0 mg/L, and the inhibition rate of 4 strains was within 2 min. The bactericidal rate is 100%. When the effective iodine content was 1 500 mg/L, there was no irritation to the intact skin, damaged skin and skin. Conclusion compared with the iodophor sold in the city, the self-made microemulsion iodine has the characteristics of safe use, quick onset, low initial concentration and good bactericidal effect, which can provide a new method for clinical disinfection.
【作者單位】： 山西醫(yī)科大學藥學院;山西大醫(yī)院;
【基金】：山西省重點學科建設(shè)經(jīng)費資助(2016)
【分類號】：R187.1
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