本文選題：超順磁性納米四氧化三鐵 + 孕鼠�。� 參考：《毒理學(xué)雜志》2017年02期

【摘要】：目的探討超順磁性納米四氧化三鐵對孕前期和孕中期小鼠生殖及胚胎發(fā)育的影響。方法選取48只健康成年雌性ICR小鼠,按體重隨機(jī)分為4組(孕前期對照組、孕前期染毒組、孕中期對照組和孕中期染毒組),分別在孕前期、孕中期經(jīng)尾靜脈注射方式染毒,均于孕18 d處死孕鼠剖取卵巢和胎鼠,測定胎鼠發(fā)育指標(biāo)(胎鼠體重、體長、尾長、外觀畸形率、內(nèi)臟畸形率、骨骼畸形率、胎盤重及HE切片)和孕鼠生育力指標(biāo)(孕鼠體重、子宮重、卵巢重及HE切片、活胎率、死胎率、吸收胎率)。結(jié)果孕前期建模組:孕鼠生育指標(biāo)兩組對比差異無統(tǒng)計學(xué)意義(P0.05)。與對照組相比,染毒組胎仔體長顯著降低(P0.05),胎盤重及吸收胎率顯著增加(P0.05),其余發(fā)育指標(biāo)差異無統(tǒng)計學(xué)意義(P0.05);孕中期建模組:孕鼠生育指標(biāo)兩組對比差異無統(tǒng)計學(xué)意義(P0.05)。與對照組相比,染毒組胎盤重量顯著降低(P0.05),其余發(fā)育指標(biāo)差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論超順磁性納米四氧化三鐵對孕前期和孕中期染毒小鼠的生育力無顯著影響,對胚胎發(fā)育有一定的毒性作用。
[Abstract]:Objective to investigate the effects of superparamagnetic nano ferric oxide on the reproductive and embryonic development of early and middle pregnant mice. Methods 48 healthy adult female ICR mice were randomly divided into 4 groups according to their body weight: control group, control group and second trimester group. On the 18th day of gestation, all the pregnant rats were killed to take ovary and fetal mice. The development indexes (body weight, body length, tail length, appearance deformity rate, visceral deformity rate, bone deformity rate, placental weight and HE section) and the fertility index (body weight of pregnant mice) were measured. Uterus weight, ovary weight and HE section, live rate, stillbirth rate, absorption rate. Results in the model group, there was no significant difference in fertility index between the two groups (P 0.05). Compared with the control group, the fetal body length of the exposed group decreased significantly, the placental weight and the rate of absorption increased significantly, and the other development indexes had no significant difference (P 0.05), while in the second trimester model group, there was no significant difference in the fertility index between the two groups (P 0.05). Compared with the control group, the placental weight of the exposed group was significantly lower than that of the control group. Conclusion the superparamagnetic nano ferric oxide has no significant effect on the fertility of mice in the first and second trimester of pregnancy, but has a certain toxic effect on embryonic development.
【作者單位】： 石河子大學(xué)醫(yī)學(xué)院預(yù)防醫(yī)學(xué)系;
【基金】：國家自然科學(xué)基金項目(81560536) 復(fù)旦大學(xué)開放課題(FDLAP14003) 石河子大學(xué)科技發(fā)展項目(RCZX201331) 國家級大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計劃項目(201510759062)
【分類號】：R114

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1 胡立丹;不同粒徑納米四氧化三鐵對小鼠肝腎功能的影響[D];南華大學(xué);2015年

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