太原市社區(qū)絕經(jīng)期H型高血壓患者與其雌激素水平的多重影響因素相關(guān)性分析
發(fā)布時間:2018-05-13 03:05
本文選題:H型高血壓 + 雌激素。 參考:《山西醫(yī)科大學》2013年碩士論文
【摘要】:研究目的 1.調(diào)查分析太原市杏花嶺社區(qū)居民中絕經(jīng)女性H型高血壓患者的相關(guān)危險因素,并探討其雌激素水平的影響因素; 2.探討絕經(jīng)女性H型高血壓患者血漿中雌激素水平、Hcy與肥胖的關(guān)系。統(tǒng)計分析得出結(jié)論,為太原市杏花嶺社區(qū)中絕經(jīng)女性H型高血壓患者的護理提供理論依據(jù)。 研究方法 采用隨機、整群抽樣方法,抽取太原市杏花嶺社區(qū)常住居民2000人進行調(diào)查,對初步研究人群按照納入、排除標準篩選得到最終研究目標人群,男性127例,女性382例。根據(jù)問診結(jié)果將女性分為絕經(jīng)組和未絕經(jīng)組。問卷調(diào)查一般資料,醫(yī)學體檢并采集空腹肘靜脈血液,測定血糖、血脂和Hcy。篩選出符合要求的女性H型高血壓患者,留取其靜脈血,30分鐘內(nèi)實驗室離心處理,留取血漿后置冰箱-20℃統(tǒng)一編號保存(一式兩份),待所有標本備齊后統(tǒng)一測定,采用放射免疫分析法測定篩選出的女性患者的雌二醇水平。統(tǒng)計分析絕經(jīng)女性H型高血壓患者的危險因素及與雌激素的相關(guān)性。 研究結(jié)果 1.在生化指標中,男性血漿中TC為5.14±0.91mmol/L,,女性為5.56±0.74mmol/L;男性TG為1.85±1.02mmol/L,女性為2.61±1.26mmol/L;男性Hcy為17.78±7.65umol/L,女性為23.88±5.22umol/L。女性平均TG、TC及Hcy均高于男性(P0.01);在吸煙、飲酒、高血壓史等一般資料方面,男女也存在顯著差異(P<0.05); 2.未絕經(jīng)H型高血壓組與已絕經(jīng)H型高血壓組相比較,年齡、腰圍、高血壓史、Hcy、E2,差異有統(tǒng)計學意義(P0.01); 3.E2與Hcy呈顯著負相關(guān),相關(guān)系數(shù)為-0.840(P<0.01); 4.絕經(jīng)女性H型高血壓患者血漿中Hcy的危險因素有BMI(P<0.01)、腰圍(P<0.01)、E2(P<0.01)、TC(P<0.05);多因素logistic回歸顯示,收縮壓、舒張壓和高血壓病程是絕經(jīng)女性H型高血壓的危險因素,而雌二醇為絕經(jīng)女性H型高血壓的保護因素; 5.影響絕經(jīng)女性H型高血壓患者血漿中E2水平的因素有年齡(P<0.01)、BMI(P<0.01)、LDL(P<0.05)。 結(jié)論 1.太原市杏花嶺社區(qū)絕經(jīng)女性雌激素水平低可能是H型高血壓發(fā)病的重要影響因素,吸煙、飲酒和血糖可能不是絕經(jīng)期H型高血壓的危險因素; 2.Hcy水平在絕經(jīng)后隨女性年齡增高而升高,不隨男性的年齡增高而升高; 3.肥胖可能是影響絕經(jīng)女性雌激素和Hcy水平的一個健康因素。
[Abstract]:Research purpose 1. To investigate the risk factors of H type hypertension in postmenopausal women in Xinghualing community residents of Taiyuan City and to explore the influencing factors of estrogen level. 2. To investigate the relationship between plasma estrogen level and obesity in postmenopausal women with H-type hypertension. The statistical analysis provides a theoretical basis for nursing of postmenopausal female patients with H-type hypertension in Xinghualing community of Taiyuan. Research method 2000 residents of Xinghualing community in Taiyuan were selected by random and cluster sampling method. According to the inclusion and exclusion criteria, the final target population was obtained, including 127 males and 382 females. Women were divided into menopausal group and premenopausal group according to the results of inquiry. General data of questionnaire survey, medical examination and blood collection of fasting cubitus vein, blood glucose, blood lipid and Hcy. Female patients with H type hypertension were selected and their venous blood was collected for centrifugal treatment in laboratory within 30 minutes, and plasma was stored in a common number of refrigerators at 20 鈩
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