發(fā)布時(shí)間：2018-05-07 20:30

  本文選題：錳 + 對(duì)氨基水楊酸鈉��； 參考：《廣西醫(yī)科大學(xué)》2013年碩士論文

【摘要】：[目的]觀察對(duì)氨基水楊酸鈉(PAS-Na)對(duì)錳中毒大鼠學(xué)習(xí)記憶能力和神經(jīng)發(fā)生水平的影響。[方法]40只健康成年雄性SD大鼠被隨機(jī)分為對(duì)照組和染錳組。染錳組、每日腹腔注射(ip) MnCl2·4H2O15mg/kg,對(duì)照組ip等容量生理鹽水,每周5天,連續(xù)6周。然后,將染錳組分為染錳組、低、中、高PAS-Na (L、M、H-PAS)治療組,L、M、H-PAS治療組每日分別背部皮下注射(sc) PSA-Na100、200或300mg/kg,對(duì)照組、染錳組背部sc等容量生理鹽水,每周用藥4天,停藥3天,連續(xù)4周。采用Morris水迷宮系統(tǒng)檢測大鼠學(xué)習(xí)記憶能力,免疫組化檢測5-溴脫氧尿嘧啶核苷(BrdU)標(biāo)記的神經(jīng)發(fā)生細(xì)胞數(shù)量。[結(jié)果]染錳組逃避潛伏期、游泳路程均比對(duì)照組長,平臺(tái)穿越次數(shù)比對(duì)照組少(P0.01)。各PAS-Na治療組逃避潛伏期、游泳路程均較染錳組短,M-、H-PAS治療組平臺(tái)穿越次數(shù)比染錳組多(P0.05或0.01)。染錳組海馬BrdU陽性細(xì)胞數(shù)目低于對(duì)照組,M-、H-PAS治療組BrdU陽性細(xì)胞數(shù)目高于染錳組(P0.01)。[結(jié)論]錳暴露能減弱成年大鼠學(xué)習(xí)記憶能力,降低海馬神經(jīng)發(fā)生水平。PAS-Na可以改善錳中毒大鼠的學(xué)習(xí)記憶能力,促進(jìn)其海馬神經(jīng)發(fā)生
[Abstract]:[objective] to observe the effects of sodium p aminosalicylate PAS-Naon on learning and memory ability and neurogenesis in rats with manganese poisoning. [methods] Forty healthy adult male SD rats were randomly divided into control group and manganese-exposed group. In the manganese exposed group, MnCl2 4H 2O 15 mg / kg daily was injected intraperitoneally, while the control group was given IP saline for 5 days a week for 6 weeks. Then, the manganese exposed group was divided into two groups: low, medium and high PAS-Na group. The treatment group was given subcutaneous injection of PSA-Na100200 or 300mg / kg PSA-Na100200 respectively. The control group and the manganese exposed group received saline of the same volume, 4 days a week, 3 days a week, and 4 weeks in succession. The learning and memory abilities of rats were measured by Morris water maze system and the number of neurogenesis cells labeled with 5-bromodeoxyuridine (BrdU) was detected by immunohistochemistry. [results] the escape latency and swimming distance of manganese exposed group were all higher than that of control group, and the times of platform crossing were less than that of control group (P 0.01). The escape latency and swimming distance of each PAS-Na treatment group were shorter than those of the manganese exposed group. The number of platform crossing in the treatment group was more than that in the manganese exposed group (P0.05 or 0.01). The number of BrdU positive cells in hippocampus of manganese exposed group was lower than that of control group. The number of BrdU positive cells in treatment group was higher than that in manganese exposed group. [conclusion] Manganese exposure can attenuate the learning and memory ability of adult rats and decrease the level of hippocampal neurogenesis. PAS-Na can improve the learning and memory ability and promote the development of hippocampal nerve in rats with manganese poisoning.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R114

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