本文選題：新型毒品濫用 + 生活質(zhì)量��； 參考：《華中科技大學(xué)》2013年碩士論文

【摘要】：目的：（1）了解武漢地區(qū)新型毒品濫用情況及濫用者身心和睡眠狀況；（2）探索色氨酸對新型毒品濫用者睡眠和身心癥狀的治療效果。 方法：采用自制的基本情況調(diào)查表、癥狀自評量表（SCL-90）和阿森斯失眠量表（AIS）對武漢市公安局強(qiáng)制隔離戒毒所2012年4月-2012年11月收治的新型毒品濫用者進(jìn)行調(diào)查，并從中篩選出80名受試對象隨機(jī)分配到試驗(yàn)組和對照組，每組40人，試驗(yàn)組接受色氨酸（1000mg/day），對照組接受安慰劑，一共服用兩周，在第一周末和第二周末分別再次進(jìn)行調(diào)查。 結(jié)果：（1）共調(diào)查323名新型毒品濫用者，其中男性和女性分別占79.6%（257/323）和20.4%（66/323）；年齡以21-30歲為主，占42.4%（137/323），平均為32.25±8.85歲；婚姻狀況以未婚為主，占50.8%（164/323）；入所前職業(yè)以無業(yè)為主，，占45.8%（148/323）；文化程度以初中及以下為主，占67.2%（217/323）；使用毒品和使用方式分別以麻谷和燙吸為主，占67.2%（217/323）和74.9%（242/323）；吸毒年限以1-5年為主，占63.8%（206/323）；第一次使用毒品原因以好奇為主，占58.5%（189/323）；使用毒品場所以私人場所為主，占45.5%（147/323），且主要為群體使用，占58.2%（188/323）。 （2）新型毒品濫用者與一般人群SCL-90各因子均分的差異均有統(tǒng)計(jì)學(xué)意義（P0.05），除人際關(guān)系得分低于一般人群，其余因子得分均高于一般人群。新型毒品濫用者中有睡眠問題者占69%（223/323），失眠者占44.5%（144/323）。苯丙胺類濫用者與K粉濫用者在人際關(guān)系、偏執(zhí)、精神病性之間的差異無統(tǒng)計(jì)學(xué)意義（P0.05），而SCL-90其余的因子和睡眠之間的差異均有統(tǒng)計(jì)學(xué)意義（P0.05）。 （3）試驗(yàn)組和對照組在治療依從性和所有的基線資料上沒有差異（P0.05）。兩組間在阿森斯睡眠量表的分值上有差異（P0.05），且試驗(yàn)組分值下降較對照組明顯，但二者在癥狀自評量表方面卻沒有差異（P0.05），包括所有的維度和總分。整個(gè)研究過程中沒有出現(xiàn)嚴(yán)重的負(fù)面事件，且兩組間出現(xiàn)負(fù)面事件的頻率沒有差異（P0.05）。結(jié)論：（1）武漢地區(qū)新型毒品濫用者身心和睡眠質(zhì)量較差，相關(guān)部門應(yīng)該采取有針對性的措施，提高新型毒品患者身心健康狀況。 （2）色氨酸可以短期內(nèi)緩解新型毒品濫用者的睡眠癥狀，但不能緩解其身心癥狀。
[Abstract]:Objective to explore the therapeutic effect of tryptophan on sleep and psychosomatic symptoms of new drug abusers in Wuhan. Methods: the self-made basic information questionnaire, symptom Checklist 90 (SCL-90) and AIS (AIS) were used to investigate the new drug abusers treated in the compulsory isolation drug treatment center of Wuhan Public Security Bureau from April 2012 to November 2012. 80 subjects were randomly assigned to the experimental group and the control group, 40 in each group. The experimental group received 1000 mg / d tryptophan and the control group received a placebo for two weeks. The study was conducted again at the first weekend and the second weekend. Results: (1) A total of 323 new drug abusers were investigated, of whom 79.6% were male and 79.6% 323%, and 20.466% 323%; the age was mainly 21-30 years old, accounting for 42.47% 32330 years, with an average of 32.25 鹵8.85 years old; marriage status was mainly unmarried, accounting for 50.816 / 323%; and before entering the university, the occupation was dominated by non-employment. 45.8% / 323%; the education level is mainly junior high school and below, accounting for 67.2% of 323%; the use of drugs and the way of using drugs are mainly hemp valley and hot suction, respectively, 67.22% 323) and 74.9% 242 / 323; the number of years of drug use is 1-5 years, accounting for 63.8% 206323%; the first use of drugs is mainly because of curiosity. 58.5% 1899 / 323; drug use was mainly in private places, accounting for 45.5% of 323%, and was mainly used in groups, accounting for 58.2% of the total. (2) there were significant differences in the average scores of SCL-90 between the new drug abusers and the general population (P 0.05). The scores of other factors were higher than those of the general population, except the interpersonal relationship score was lower than that of the general population. Among the new drug abusers, sleep problems accounted for 69 / 223 / 323, and insomnia for 44. 5 / 324 / 323. There was no significant difference in interpersonal relationship, paranoid ideation and psychosis between amphetamine-type abusers and K-substance abusers, but the differences between other factors of SCL-90 and sleep were statistically significant (P 0.05). There was no difference in treatment compliance and all baseline data between the trial group and the control group (P 0.05). There were significant differences in Ascension sleep scale scores between the two groups, and the scores of the test group were significantly lower than those of the control group, but there was no difference in the symptom Checklist between the two groups, including all dimensions and total scores. There were no serious negative events in the whole study, and there was no difference in the frequency of negative events between the two groups (P 0.05). Conclusion (1) the mental, physical and sleep quality of new-type drug abusers in Wuhan area is poor. Relevant departments should take targeted measures to improve the physical and mental health of new-type drug abusers. Tryptophan can relieve sleep symptoms of new drug abusers in the short term, but not physical and mental symptoms.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R163

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