本文選題：砷 + 全血　； 參考：《環(huán)境與健康雜志》2015年12期

【摘要】：目的了解遼寧省一般人群全血和尿液中砷水平的分布,并分析其流行分布特點(diǎn)。方法采用整群隨機(jī)抽樣的方法,于2009—2010年在遼寧省東、中、西部3個(gè)城市的區(qū)縣中,抽取2 105名6~60歲人群作為調(diào)查對象,進(jìn)行血、尿樣品采集和問卷調(diào)查。應(yīng)用電感耦合等離子體質(zhì)譜法檢測樣品中砷水平,分析在不同性別、年齡、地區(qū)和生活方式中砷水平分布情況。結(jié)果調(diào)查對象血砷幾何均數(shù)為3.68μg/L,95%CI為3.55~3.80μg/L,男性血砷幾何均數(shù)(3.90μg/L)高于女性(3.46μg/L)(P0.01)。各年齡組血砷的幾何均數(shù)差異具有統(tǒng)計(jì)學(xué)意義(P0.01),其中46~60歲年齡組血砷最高(為5.07μg/L),17~20歲年齡組血砷最低(為2.19μg/L)。遼寧省東、中、西部地區(qū)人群血砷幾何均數(shù)分別為5.06、2.67和3.15μg/L(P0.01)。調(diào)查對象尿砷幾何均數(shù)為21.27μg/L,95%CI為20.37~22.25μg/L。男性尿砷幾何均數(shù)(22.76μg/L)顯著高于女性(19.85μg/L)(P0.01)。不同年齡組人群尿砷幾何均數(shù)差異有統(tǒng)計(jì)學(xué)意義(P0.01),其中13~16歲年齡組尿砷最低(為14.97μg/L),31~45歲年齡組尿砷最高(為32.04μg/L);遼寧省東、中、西部地區(qū)人群尿砷幾何均數(shù)分別為25.81、17.34和21.40μg/L(P0.01)。在吸煙、飲酒和攝食海鮮人群中血砷、尿砷均增高(P0.01)。遼寧省一般人群血砷水平與尿砷水平呈正相關(guān)(r=0.189,P0.01)。遼寧省一般人群血砷幾何均數(shù)(3.68μg/L)高于全國一般人群(2.33μg/L)(P0.01);遼寧省尿砷幾何均數(shù)(21.27μg/L)高于全國(13.72μg/L)(P0.01)。結(jié)論遼寧省一般人群血砷和尿砷水平在性別、年齡、區(qū)域和生活方式特征中均存在差異。遼寧省一般人群血砷和尿砷水平顯著高于全國一般人群水平。
[Abstract]:Objective to investigate the distribution of arsenic in whole blood and urine in Liaoning province and analyze its epidemic distribution. Methods A cluster random sampling method was used to collect blood and urine samples and questionnaires from 2 105 people aged 6 to 60 years from 2009 to 2010 in the districts and counties of three cities in east, middle and west of Liaoning Province. Inductively coupled plasma mass spectrometry (ICP-MS) was used to detect arsenic levels in samples and to analyze the distribution of arsenic levels in different sex, age, region and lifestyle. Results the geometric mean of blood arsenic was 3.68 渭 g / L ~ (95) CI was 3.55 ~ 3.80 渭 g / L, and that of male was 3.90 渭 g / L, which was higher than that of female (3.46 渭 g / L ~ (-1) P ~ (0.01). There were statistically significant differences in the geometric mean of blood arsenic among different age groups (P 0.01), and the highest was in the age group of 46 ~ 60 (5.07 渭 g / L / L) (5.07 渭 g / L) and the lowest (2.19 渭 g / L) in the age group of 20 years old (2.19 渭 g / L). The geometric mean of blood arsenic in the east, middle and west areas of Liaoning Province was 5.062.67 and 3.15 渭 g / L, respectively. The geometric mean of urinary arsenic was 21.27 渭 g / L ~ (95) CI = 20.37 ~ 22.25 渭 g 路L ~ (-1) 路L ~ (-1). The geometric mean of urinary arsenic in men (22.76 渭 g / L) was significantly higher than that in women (19.85 渭 g / L). There were significant differences in the geometric mean of urinary arsenic among different age groups (P 0.01), among which the 1316 age group had the lowest urine arsenic (14.97 渭 g / L) and the highest (32.04 渭 g / L) urine arsenic in 45 years old, and the geometric mean value of urinary arsenic was 25.8117.34 and 21.40 渭 g / L (P 0.01) in east, middle and west Liaoning Province, respectively. In smoking, drinking and eating seafood, the levels of arsenic in blood and urine were all increased (P 0.01). There was a positive correlation between blood arsenic level and urinary arsenic level in general population in Liaoning Province. The geometric mean of blood arsenic in the general population of Liaoning Province was 3.68 渭 g / L) higher than that in the general population of China (2.33 渭 g / L), and the geometric mean of urinary arsenic in Liaoning Province was 21.27 渭 g / L) higher than that in the whole country (13.72 渭 g / L). Conclusion there are differences in blood arsenic and urinary arsenic levels in sex, age, region and lifestyle characteristics of general population in Liaoning Province. The levels of blood arsenic and urinary arsenic in general population in Liaoning Province were significantly higher than those in the general population in China.
【作者單位】： 中國疾病預(yù)防控制中心職業(yè)衛(wèi)生與中毒控制所化學(xué)污染與健康安全重點(diǎn)實(shí)驗(yàn)室;丹東市疾病預(yù)防控制中心;沈陽市勞動(dòng)衛(wèi)生職業(yè)病研究所檢驗(yàn)科;遼寧醫(yī)學(xué)院附屬醫(yī)院檢驗(yàn)科;
【基金】：衛(wèi)生部衛(wèi)生公益性行業(yè)科研專項(xiàng)(200802020) 國家科技支撐計(jì)劃項(xiàng)目(2006BAI06B02) 沈陽市科學(xué)計(jì)劃項(xiàng)目(1091165-9-00)
【分類號(hào)】：R114

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