本文選題：鉛鋅礦開(kāi)采區(qū) + 鋅鎘混合接觸�。� 參考：《大理學(xué)院》2013年碩士論文

【摘要】：[目的] 進(jìn)一步研究鉛鋅礦開(kāi)采區(qū)人群體內(nèi)鋅、鎘負(fù)荷及健康狀況，評(píng)價(jià)鉛鋅礦開(kāi)采區(qū)環(huán)境鋅鎘混合接觸對(duì)職業(yè)人群健康的影響，探索其影響的氧化應(yīng)激機(jī)制。 [方法] 在怒江蘭坪鉛鋅礦開(kāi)采區(qū)前期進(jìn)行有關(guān)研究的基礎(chǔ)上，確定鉛鋅礦開(kāi)采區(qū)與非鉛鋅礦開(kāi)采區(qū)。在鉛鋅礦開(kāi)采區(qū)內(nèi)選擇工作3年及以上的工人為接觸組，在非鉛鋅礦開(kāi)采區(qū)選擇距鉛鋅礦開(kāi)采區(qū)較遠(yuǎn)且無(wú)水系聯(lián)系，不受工業(yè)污染，而生活習(xí)慣、社會(huì)經(jīng)濟(jì)狀況基本相同，從未接觸過(guò)重金屬毒物的居民作為對(duì)照組。通過(guò)對(duì)研究對(duì)象常規(guī)體格檢查和問(wèn)卷調(diào)查，，掌握鉛鋅礦開(kāi)采區(qū)職業(yè)人群健康狀況的情況；通過(guò)對(duì)研究對(duì)象進(jìn)行發(fā)樣、血樣的采集，分析接觸組與對(duì)照組體內(nèi)鋅、鎘負(fù)荷及其血清中超氧化物歧化酶（T-SOD)、丙二醛（MDA)、谷胱甘肽氧化酶（GSH-Px)等指標(biāo)的變化，評(píng)價(jià)鉛鋅礦開(kāi)采區(qū)環(huán)境鋅鎘混合接觸對(duì)職業(yè)人群健康的影響，探索其影響的氧化應(yīng)激機(jī)制。 [結(jié)果] 1.接觸組與對(duì)照組之間發(fā)鋅、血鋅含量的差異具有統(tǒng)計(jì)學(xué)意義（P0.05)，且接觸組發(fā)鋅高于對(duì)照組，血鋅低于對(duì)照組。接觸組與對(duì)照組之間發(fā)鎘、血鎘含量的差異具有統(tǒng)計(jì)學(xué)意義（P0.05)，接觸組發(fā)鎘、血鎘均高于對(duì)照組。 2.接觸組發(fā)鎘、血鎘隨著工齡的增長(zhǎng)而增加，且差異均具有統(tǒng)計(jì)學(xué)意義（P0.05)。 3.接觸組腰痛、關(guān)節(jié)痛、頭痛、頭暈、記憶力減退、全身酸痛、牙痛、刷牙出血、疲乏無(wú)力、腹痛的發(fā)生率均高于對(duì)照組，且差異具有統(tǒng)計(jì)學(xué)意義（P0.05) 4.接觸組與對(duì)照組之間血清超氧化物歧化酶（T-SOD)活力、血清谷胱甘肽氧化酶(GSH-Px)活力的差異具有統(tǒng)計(jì)學(xué)意義（P0.05)，且接觸組血清超氧化物歧化酶(T-SOD)、谷胱甘肽氧化酶（GSH-Px)活力低于對(duì)照組。 [結(jié)論] 1.暴露在鋅、鎘污染環(huán)境條件下的接觸組體內(nèi)的鋅、鎘負(fù)荷受到影響。接觸組發(fā)鋅、發(fā)鎘、血鎘含量高于對(duì)照組；接觸組血鋅含量低于對(duì)照組。 2.暴露在鋅、鎘污染環(huán)境條件下的接觸組的血清超氧化物歧化酶（T-SOD)活力、血清谷胱甘肽氧化酶（GSH-Px)活力均低于對(duì)照組。 3.鉛鋅礦開(kāi)采區(qū)人群的體內(nèi)鎘負(fù)荷隨著工齡的增長(zhǎng)而增加。 4.在鋅、鎘混合接觸的情況下職業(yè)人群的健康狀況受到了危害。
[Abstract]:[purpose]The effects of mixed exposure of zinc and cadmium on the health of occupational population in lead-zinc mining area were evaluated and the mechanism of oxidative stress was explored.[methods]On the basis of the previous research in Lanping lead-zinc mining area of Nujiang River, the lead-zinc mining area and the non-lead-zinc mining area are determined.In the lead-zinc mining area, workers who have worked for 3 years or more are selected as contact groups. In the non-lead-zinc mining areas, the workers are chosen to be far away from the lead-zinc mining areas and have no connection with water systems, so they are not affected by industrial pollution, and their living habits and social and economic conditions are basically the same.Residents who had never been exposed to heavy metal poisons served as a control group.By routine physical examination and questionnaire survey, the health status of the occupational population in the lead-zinc mining area was mastered, and the zinc in the exposed group and the control group were analyzed by collecting samples of hair and blood.Cadmium loading and the changes of serum superoxide dismutase (T-SOD), malondialdehyde (MDA), glutathione oxidase (GSH-Px) and so on were used to evaluate the effect of mixed exposure of Zn and CD on the health of occupational population in lead-zinc mining area and to explore the mechanism of oxidative stress.[results]1.The difference of hair zinc and blood zinc content between the exposure group and the control group was statistically significant (P 0.05), and the hair zinc content of the contact group was higher than that of the control group, and the blood zinc content was lower than that of the control group.The difference of hair cadmium and blood cadmium content between the exposed group and the control group was statistically significant (P 0.05). The hair cadmium and blood cadmium in the contact group were higher than those in the control group.2.In the exposed group, the cadmium and blood cadmium increased with the increase of the length of service, and the difference was statistically significant (P 0.05).3.The incidence of low back pain, joint pain, headache, dizziness, memory loss, general soreness, toothache, bleeding from brushing teeth, fatigue and abdominal pain in the contact group were higher than those in the control group (P 0.05).4.The activity of serum superoxide dismutase (T-SOD) and glutathione oxidase (GSH-Px) were significantly different between the exposed group and the control group, and the activities of serum superoxide dismutase (T-SOD) and glutathione oxidase (GSH-Px) in the exposed group were lower than those in the control group.[conclusion]1.Exposure to zinc, cadmium pollution environmental conditions in the exposure group zinc, cadmium load is affected.The contents of hair zinc, hair cadmium and blood cadmium in the exposure group were higher than those in the control group, and the blood zinc content in the exposure group was lower than that in the control group.2.The activities of serum superoxide dismutase (T-SOD) and glutathione oxidase (GSH-Px) in the exposed group were lower than those in the control group.3.The cadmium load of the population in lead-zinc mining area increases with the increase of working age.4.The health status of the occupational population is jeopardized by mixed exposure to zinc and cadmium.
【學(xué)位授予單位】：大理學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R13

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