本文選題：瑞士乳桿菌TS　切入點：血脂　出處：《食品科學》2017年11期

【摘要】：探討瑞士乳桿菌TS206(Lactobacillus helveticus TS206)對小鼠血脂水平的影響。以健康BABL/c小鼠為對象,設置實驗組和對照組,分別以L.helveticus TS206菌懸液和生理鹽水(0.2 m L/d)連續(xù)灌胃7周,監(jiān)測小鼠體質(zhì)量和血脂(總膽固醇(total serum cholesterol,TC)、甘油三酯(triglycerides,TG)水平、高密度脂蛋白膽固醇(high density lipoprotein cholesterol,HDL-C)和低密度脂蛋白膽固醇(low density lipoprotein cholesterol,LDL-C))以及糞便總膽汁酸(total bile acid,TBA)水平的變化。灌胃L.helveticus TS206后,小鼠體質(zhì)量增量顯著高于對照組(P0.05,P0.01);血清中TC、TG和LDL-C水平均顯著降低(P0.05),灌胃停止1周后基本恢復到對照組水平;L.helveticus TS206菌懸液和生理鹽水小鼠血清中HDL-C含量均無顯著性變化;TBA水平呈先下降后上升趨勢,且3周后TBA水平顯著低于對照組(P0.05)。研究結(jié)果表明,L.helveticus TS206能促進健康小鼠體質(zhì)量增加,并有效調(diào)控其血脂水平,提示口服L.helveticus TS206菌劑可能會降低患心腦血管疾病的風險。
[Abstract]:To investigate the effect of Lactobacillus TS206(Lactobacillus helveticus TS206 on blood lipid levels in mice.Healthy BABL/c mice were divided into experimental group and control group. The mice were perfused with L.helveticus TS206 suspension and normal saline 0.2 mL / d for 7 weeks, respectively. The body weight and serum lipids (TGs) of the mice were monitored.Changes of high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-CU) and total total bile acid (total bile acidine) in feces.After intragastric administration of L.helveticus TS206,The body weight increment of mice was significantly higher than that of the control group (P 0.05, P 0.01), and the levels of serum TCU TG and LDL-C were significantly lower than those of the control group. After one week of gastric administration, the levels of HDL-C in the serum of mice with L.helveticus TS206 and normal saline were basically restored to the control level. There was no significant change in HDL-C content in the serum of mice with normal saline and the suspension of L.helveticus TS206.The level of TBA decreased first and then increased.After 3 weeks, the level of TBA was significantly lower than that of control group (P 0.05).The results showed that L.helveticus TS206 could promote the increase of body mass and regulate the blood lipid level of healthy mice, suggesting that oral L.helveticus TS206 could reduce the risk of cardiovascular and cerebrovascular diseases.
【作者單位】： 天津市食品生物技術重點實驗室天津商業(yè)大學生物技術與食品科學學院;
【基金】：國家自然科學基金面上項目(31071522) 天津市科技創(chuàng)新體系及條件平臺建設項目(100005)
【分類號】：R151

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