本文選題：納米硫化鉛　切入點：學(xué)習(xí)記憶　出處：《環(huán)境與健康雜志》2015年07期

【摘要】：目的探討納米硫化鉛染毒對大鼠學(xué)習(xí)記憶能力及海馬組織中銅、鋅含量的影響。方法將24只健康成年SPF級SD雄性大鼠隨機分為3組,分別為對照(高溫滅菌生理鹽水)組和15、30 mg/kg納米硫化鉛染毒組,每組8只。采用氣管注入法進(jìn)行染毒,染毒容積為5 ml/kg,每周1次,連續(xù)染毒3個月。采用Morris水迷宮實驗檢測大鼠的學(xué)習(xí)記憶能力,測定全血和海馬組織中鉛含量以及海馬組織中銅、鋅含量及其比值。結(jié)果與對照組比較,各劑量納米硫化鉛染毒大鼠的逃避潛伏期和首次到達(dá)平臺時間均延長,停留目的象限時間縮短,穿越平臺次數(shù)減少,全血和海馬組織中的鉛含量均較高,海馬組織中的銅、鋅含量及其比值均較低,差異均有統(tǒng)計學(xué)意義(P0.05);且隨著納米硫化鉛染毒劑量的升高,大鼠的逃避潛伏期和首次到達(dá)平臺時間均呈延長趨勢,停留目的象限時間呈縮短趨勢,穿越平臺次數(shù)呈減少趨勢,全血和海馬組織中的鉛含量均呈上升趨勢,海馬組織中的銅、鋅含量及其比值均呈下降趨勢。結(jié)論納米硫化鉛可致大鼠學(xué)習(xí)記憶能力降低,并引起海馬組織中銅鋅含量、銅/鋅比值的下降。
[Abstract]:Objective to investigate the effects of nano-lead sulfide exposure on learning and memory ability and the contents of copper and zinc in hippocampus of rats. Methods 24 healthy adult SD rats of SPF grade were randomly divided into 3 groups. 8 rats in each group were exposed to sodium sulphide for 15 ~ 30 mg/kg, respectively. The volume of exposure was 5 ml / kg, once a week, by trachea injection, and the volume of exposure was 5 ml / kg, once a week, and the volume of exposure was 5 ml 路kg ~ (-1) 路kg ~ (-1), respectively. Morris water maze test was used to test the learning and memory ability of rats. The contents of lead in whole blood and hippocampus, copper and zinc in hippocampus and their ratios were measured by Morris water maze test. The results were compared with those in control group. The escape latency and the first arrival time were prolonged, the duration of stay in the quadrant was shortened, the number of crossing the platform was decreased, the lead content in the whole blood and hippocampus was higher, and the copper content in the hippocampus was higher than that in the control group. The zinc content and its ratio were lower, the difference was statistically significant (P 0.05), and with the increase of the dose of lead sulfide, the escape latency and the first arrival time of the rats showed a tendency of prolonging, while the time of staying in the target quadrant showed a tendency of shortening. The times of crossing the platform decreased, the lead content in whole blood and hippocampus increased, and the copper, zinc and its ratio in hippocampus decreased. Conclusion the learning and memory ability of rats can be decreased by nanometer lead sulfide. The content of Cu and Zn and the ratio of Cu / Zn in hippocampus were decreased.
【作者單位】： 華北理工大學(xué)公共衛(wèi)生學(xué)院;北京軍區(qū)北戴河療養(yǎng)院;邢臺市第三醫(yī)院醫(yī)院感染科;開灤總醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R114

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