本文選題：維生素D　切入點：孕婦　出處：《青島大學(xué)》2017年碩士論文

【摘要】：目的:研究費(fèi)縣地區(qū)孕母產(chǎn)前與新生兒維生素D營養(yǎng)狀況及其影響因素,分析孕母產(chǎn)前與新生兒維生素D營養(yǎng)狀況及其影響因素之間的關(guān)系。方法:隨機(jī)選取2016年1月-2016年12月在費(fèi)縣人民醫(yī)院進(jìn)行查體和生育的孕母和其所分娩的新生兒各100例,作為研究對象。通過調(diào)查問卷和查看病史資料收集孕母的相關(guān)信息、孕期身體狀況和分娩后新生兒相關(guān)情況。征得患者同意后進(jìn)行采樣,應(yīng)用液相色譜串聯(lián)質(zhì)譜法來檢測血清維生素D水平。有關(guān)孕母分娩及新生兒出生情況,從保健手冊上查閱得到。不同季節(jié)孕母及新生兒維生素D水平的差異采用多樣本秩和檢驗,多因素分析采用二分類logistic回歸,通過Spearman相關(guān)及偏相關(guān)分析孕母-新生兒25-(OH)D的相關(guān)性。結(jié)果:本研究共納入100例孕母及其對應(yīng)的100例新生兒,具體結(jié)果如下:1、孕母平均25-(OH)D水平為:16.92士6.82 ng/ml,其中有87%的孕母維生素D缺乏或不足。2、新生兒平均25-(OH)D水平為:17.36士5.19 ng/ml,其中有90%的新生兒維生素D缺乏或不足。3、孕母及新生兒25-(OH)D水平存在明顯的季節(jié)差異,冬春季平均14.73士6.52ng/ml,夏秋季平均為18.41士5.24ng/ml。4、除季節(jié)因素外,孕期補(bǔ)充復(fù)合維生素和孕期多曬太陽有利于孕期維持維生素D處于高水平。5、孕母和新生兒臍血25-(OH)D水平呈正相關(guān)性。結(jié)論:1、費(fèi)縣地區(qū)孕母與新生兒普遍存在維生素D缺乏或不足,并且冬春季低于夏秋季。表明該地區(qū)孕婦應(yīng)該適當(dāng)補(bǔ)充維生素D和孕期多曬太陽有利于孕期維持維生素D處于正常合理水平。2、孕母-新生兒25-(OH)D水平呈正相關(guān)性,表明母體內(nèi)的維生素D水平影響著新生兒維生素D水平。
[Abstract]:Objective: to study the nutritional status of vitamin D in pregnant mothers and newborns in Fei County and its influencing factors. The relationship between prenatal and neonatal vitamin D nutritional status and its influencing factors were analyzed. Methods: 100 pregnant mothers and 100 newborns were randomly selected from January 2016 to December 2016 in Feixian people's Hospital for physical examination and birth. As the research object. Collect the relevant information about the pregnant mother, the physical condition during pregnancy and the related situation of the newborn after delivery by questionnaire and check the medical history data. Sample with the consent of the patient. Serum vitamin D levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS). The differences of vitamin D levels between pregnant mothers and newborns in different seasons were analyzed by multi-sample rank sum test and multivariate analysis by two-classification logistic regression. Spearman correlation and partial correlation were used to analyze the relationship between pregnancy and neonatal 25-(OH)D. Results: 100 pregnant mothers and their corresponding 100 newborns were included in this study. The results are as follows: 1. The average 25-(OH)D level of pregnant mothers is: 16.92 + 6.82 ng / ml, of which 87% of pregnant mothers are deficient or deficient in vitamin D, while the average 25-(OH)D level of newborns is: 17.36 鹵5.19 ng / ml, 90% of newborns have vitamin D deficiency or deficiency of .3. There were significant seasonal differences in 25-(OH)D levels in newborns. The average value in winter and spring was 14.73 鹵6.52 ng / ml, and that in summer and autumn was 18.41 鹵5.24 ng / ml. Supplementation of multivitamins during pregnancy and multiple sun exposure during pregnancy were beneficial to maintaining a high level of vitamin D during pregnancy. There was a positive correlation between 25-(OH)D levels in umbilical cord blood of pregnant mothers and newborns. Conclusion Vitamin D deficiency or deficiency is common in pregnant mothers and newborns in Feixian area. And winter and spring are lower than in summer and autumn. The results indicate that pregnant women in this area should take appropriate vitamin D supplementation and more sun exposure during pregnancy to maintain a normal and reasonable level of vitamin D in pregnancy. The 25-(OH)D level between mother and newborn is positively correlated. The results showed that the vitamin D level in the mother affected the vitamin D level of the newborn.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R153.1

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