本文選題：四溴雙酚A　切入點：代謝特征　出處：《環(huán)境與健康雜志》2015年02期 　論文類型：期刊論文

【摘要】：四溴雙酚A(TBBPA)具有高效的阻燃效率和優(yōu)越的熱穩(wěn)定性,被廣泛用于各種電子電器產(chǎn)品、紡織品及建筑材料等,成為世界上使用量最大的阻燃劑。該文在綜述國內(nèi)外相關(guān)研究的基礎(chǔ)上,依據(jù)TBBPA的不同暴露方式總結(jié)了經(jīng)口、經(jīng)皮膚和經(jīng)呼吸暴露TBBPA的生物體代謝特征和毒性特征。TBBPA主要是通過糞便排泄,其次為尿液;TBBPA對哺乳動物的急性毒性較小,達(dá)到g/kg體重級的劑量才能引起毒性效應(yīng);慢性毒性主要表現(xiàn)為內(nèi)分泌干擾性、肝腎毒性、神經(jīng)毒性和免疫毒性等。
[Abstract]:Tetrabromobisphenol A (TBBPA) is widely used in electronic and electrical products, textiles and construction materials, because of its high flame retardant efficiency and excellent thermal stability. It is the most widely used flame retardant in the world. Based on the review of related researches at home and abroad, this paper summarizes the effects of different exposure modes of TBBPA. Metabolic and toxic characteristics of TBBPA exposed to skin and respiration. TBBPA was excreted mainly through feces, followed by urine TBBPA, which was less acute to mammals, and only when the dose of TBBPA reached the g/kg body weight level could it cause the toxic effect. Chronic toxicity is mainly characterized by endocrine disruptions, liver and kidney toxicity, neurotoxicity and immune toxicity.
【作者單位】： 中國環(huán)境科學(xué)研究院環(huán)境基準(zhǔn)和風(fēng)險評估國家重點實驗室;環(huán)境保護(hù)部華南環(huán)境科學(xué)研究所;中國疾病預(yù)防控制中心;常州大學(xué)環(huán)境與安全工程學(xué)院;
【基金】：國家自然科學(xué)基金(21177119) 環(huán)境保護(hù)部環(huán)保公益性行業(yè)科研專項(201309047)
【分類號】：R114

【參考文獻(xiàn)】

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