本文選題：黃熱病　切入點：病例報告　出處：《中華疾病控制雜志》2017年06期 　論文類型：期刊論文

【摘要】：目的查明上海首例輸入性黃熱病病例的發(fā)病情況、感染來源和傳播途徑,為我國黃熱病防控決策提供科學依據(jù)。方法通過個人訪談開展流行病學調(diào)查;采集血液、尿液及唾液,通過實時熒光聚合酶鏈式反應(polymerase chain reaction,PCR)法開展黃熱病毒核酸檢測;采用雙層疊帳法開展蚊媒密度應急監(jiān)測。結(jié)果病例3月5日在安哥拉突發(fā)高熱,7日凌晨抵滬,8日住院治療,有明確蚊蟲叮咬史,無黃熱病疫苗接種史;病后4 d的血液黃熱病毒核酸陽性,病后9 d、26 d的尿液均為陽性,病后9 d、26 d、33 d的唾液標本均為陰性。病例周邊成蚊密度為0.5只/(人·h),就醫(yī)所在的金山區(qū)3月份蚊媒密度為0.83只/(人·h)。防蚊隔離治療后,病例于4月8日痊愈出院;27名密切接觸者均未出現(xiàn)相關(guān)癥狀。結(jié)論病例感染來源于安哥拉,其發(fā)病時間(3月5日)早于我國首例病例(3月6日發(fā)病),未發(fā)生二代病例,對病例開展防蚊隔離治療和蚊媒應急監(jiān)測處置有效防止黃熱病擴散傳播。
[Abstract]:Objective to investigate the incidence, source and transmission of the first imported yellow fever case in Shanghai, so as to provide a scientific basis for the decision of prevention and control of yellow fever in China. Methods Epidemiological investigation was carried out through personal interviews, and blood, urine and saliva were collected. The detection of yellow fever virus nucleic acid was carried out by real-time fluorescent polymerase chain reaction PCR, and the emergency surveillance of mosquito vector density was carried out by double-layer accounting method. Results the case occurred in Angola on March 5th, arrived in Shanghai early on 7th, and was hospitalized on 8th. There was a clear history of mosquito bite and no history of yellow fever vaccination. The blood yellow fever virus nucleic acid was positive 4 days after the disease, and the urine of 9 days and 26 days after the disease were all positive. The saliva samples were negative at 9 days, 26 days and 33 days after the disease. The density of adult mosquitoes around the case was 0.5 / (human 路hmh, the mosquito vector density in Jinshan District, where the doctor was treated, in March) was 0.83. In April 8th, all the 27 close contacts had no related symptoms. Conclusion the infection originated in Angola and the onset time (March 5th) was earlier than that of the first case (March 6th) in China, and there was no second generation case. Antimosquito isolation treatment and mosquito vector emergency surveillance were carried out to prevent the spread of yellow fever.
【作者單位】： 上海市金山區(qū)疾病預防控制中心傳染病防制科;上海市疾病預防控制中心急性傳染病防治科;
【分類號】：R181.3;R512.8

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