本文關(guān)鍵詞： 麻疹疫苗 免疫成功率 ELISA抗體　出處：《吉林大學(xué)》2012年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：[目的]采用不同滴度效價(jià)的凍干麻疹疫苗，對(duì)初免兒童接種,為消除控制麻疹提供依據(jù)。[方法]選擇未接種過(guò)麻疹疫苗，未患過(guò)麻疹的健康兒童進(jìn)行麻疹疫苗接種,并對(duì)其接種后的一般臨床反應(yīng)進(jìn)行詳細(xì)觀察，同時(shí)對(duì)免前、免后血清抗體水平檢測(cè)。[結(jié)果]接種麻疹疫苗的嬰兒一般臨床反應(yīng)輕微，發(fā)熱率為5.7%；皮疹發(fā)生率為4.3%；局部反應(yīng)為2.8%。采用ELISA方法檢測(cè)IgG血清抗體，A組的血清抗體陽(yáng)轉(zhuǎn)率為95.23%，，免疫成功率為86%；GMT值為1364.22。B組的血清抗體陽(yáng)轉(zhuǎn)率達(dá)到了97.11%，免疫成功率86.13%；GMT值為1275.74。C組的血清抗體陽(yáng)轉(zhuǎn)率達(dá)到了96.84%，免疫成功率達(dá)到了85.65%；GMT值為1335.34。D組的血清抗體陽(yáng)轉(zhuǎn)率達(dá)到了82.53%，免疫成功率達(dá)到了72.39%；GMT值為1058.83。四組嬰兒接種后血清抗體陽(yáng)轉(zhuǎn)率、免疫成功率以及GMT值組間差異性均無(wú)統(tǒng)計(jì)學(xué)意義（P0.01）。[結(jié)論]嬰兒接種麻疹疫苗后，只要達(dá)到藥典規(guī)定的滴度要求，就能獲得良好的免疫應(yīng)答效果。
[Abstract]:[objective] to use freeze-dried measles vaccine with different titer to vaccinate children with primary immunization, and to provide basis for eliminating and controlling measles. [methods] the healthy children who have not been vaccinated against measles and healthy children who have not suffered from measles have been vaccinated against measles. At the same time, the serum antibody level before and after immunization was detected. [results] the general clinical reaction of infants inoculated with measles vaccine was slight. The fever rate was 5. 7%; the incidence of rash was 4. 3; the local reaction was 2. 8. The serum antibody positive conversion rate of group A was 95.2323 by ELISA method, and the successful rate of immunization was 1 364.22.B group. The antibody positive conversion rate of group B was 97.11 and the success rate of immunity was 97. 11%. The GMT value of 1275.74.C group reached 96.84, the successful rate of immunization reached 82.53 in group 1335.34.D, and the GMT value of 72.39m was 1058.83.The positive conversion rate of serum antibody in four groups after inoculation. There was no significant difference in immunological success rate and GMT value between groups. [conclusion] after the infants were vaccinated with measles vaccine, if they met the requirements of the pharmacopoeia, a good immune response could be obtained.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類(lèi)號(hào)】：R186

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