本文關(guān)鍵詞： 硝酸釤 慢性暴露 血流動(dòng)力學(xué) 心臟組織結(jié)構(gòu) 血常規(guī) 稀土　出處：《中國(guó)稀土學(xué)報(bào)》2015年05期 　論文類(lèi)型：期刊論文

【摘要】：探討Sm(NO3)3慢性暴露對(duì)大鼠血流動(dòng)力學(xué)、心臟組織結(jié)構(gòu)及血常規(guī)指標(biāo)的影響。SD大鼠48只,雌雄各半,隨機(jī)分成4組,分別自由飲用0,3,4.5,6 mg·L-1Sm(NO3)3溶液180 d。開(kāi)胸取心時(shí)采血進(jìn)行血常規(guī)測(cè)定,心臟光鏡切片觀察心肌組織形態(tài)學(xué)的變化;部分心臟離體后應(yīng)用Langendorff離體心臟灌流模型,觀察Sm(NO3)3慢性暴露對(duì)大鼠心臟功能的影響。結(jié)果顯示3 mg·L-1組LVSP,+dp/dtmax極顯著地增高(p0.01),CF顯著下降(p0.05);但4.5,6 mg·L-1組LVSP顯著增高(p0.05),LVEDP,+dp/dtmax,-dp/dtmax,HR,CF等指標(biāo)無(wú)明顯改變;3,4.5 mg·L-1Sm(NO3)3組WBC,MID,Lym數(shù)與對(duì)照相比有極顯著和顯著增高(p0.01,p0.05)。3 mg·L-1組心肌充血出血,肌束呈波浪狀,肌細(xì)胞體積增大,胞漿內(nèi)呈紅染的顆粒狀變性,核輕度增大。4.5 mg·L-1組心肌內(nèi)皮細(xì)胞增生,小灶肌束斷裂,部分細(xì)胞顆粒狀變性。6 mg·L-1組心肌肌束排列紊亂,微灶細(xì)胞變性壞死,細(xì)胞核消失,間質(zhì)少量淋巴細(xì)胞浸潤(rùn)。以上結(jié)果表明一定濃度Sm(NO3)3對(duì)離體大鼠心臟有正性變力作用;增加WBC,MID,Lym數(shù),并可導(dǎo)致心肌組織的代償性增生與損傷。
[Abstract]:To investigate the effects of chronic exposure to Sm(NO3)3 on hemodynamics, cardiac tissue structure and blood routine indexes in rats. Forty-eight SD rats, half male and half male, were randomly divided into 4 groups, each of which was free to drink 0 ~ (3). 4.5mg 路L -1 Smnno _ 3O _ 3 solution for 180 days. Blood samples were collected for routine blood routine examination and myocardial histomorphology was observed by light microscope section of the heart. Langendorff isolated heart perfusion model was used in some isolated hearts. The effects of chronic exposure to Sm(NO3)3 on cardiac function in rats were observed. The results showed that LVSP and dp/dtmax in 3 mg 路L -1 group were significantly higher than those in control group (P 0.01). CF decreased significantly (P 0.05); However, the LVSP of 4.5 mg 路L -1 group was significantly higher than that of p0.05 mg 路L -1 group, but DP / dtmax-dp / dtmax-dtmax-dtmax-dtmax-dtmax-dtmax-dtmax-HR-CF had no significant change. (3) the Lym number of MIDN in the 3 groups (4.5 mg 路L -1) was significantly higher than that in the control group (P 0.01). In the p0.05 mg 路L -1 group, myocardial hyperemia and haemorrhage were observed, the muscle bundles were wavy, the volume of the muscle cells was enlarged, and the cytoplasm was reddish-stained granular degeneration. The myocardial endothelial cells proliferated, the small muscle bundles were broken, and some of the cells in the group of granular degeneration of some cells were in disorder, and the microfocal cells were degenerative and necrotic in the group of mild increase of nucleus and 4.5 mg 路L ~ (-1). The results showed that Sm(NO3)3 at a certain concentration had a positive effect on isolated rat heart. Increasing the number of Lym in WBC MIDN could lead to compensatory proliferation and injury of myocardial tissue.
【作者單位】： 浙江師范大學(xué)行知學(xué)院;浙江科技學(xué)院生物與化學(xué)工程學(xué)院;金華市中心醫(yī)院病理科;浙江師范大學(xué)化學(xué)與生命科學(xué)學(xué)院;衢州職業(yè)技術(shù)學(xué)院醫(yī)學(xué)院;
【基金】：浙江省教育廳項(xiàng)目(Y201329454) 浙江省自然科學(xué)基金項(xiàng)目(Y5110135)資助
【分類(lèi)號(hào)】：R114
【正文快照】： 稀土(rare earth element,RE)是指位于周期表中第ⅢB簇的一組元素,由La,Ce,Sm等8個(gè)元素的輕稀土和Gd等9個(gè)元素的重稀土組成。我國(guó)是稀土資源大國(guó)[1],稀土以及稀土元素被廣泛應(yīng)用到多個(gè)領(lǐng)域,如農(nóng)業(yè)、畜牧業(yè)、工業(yè)、高新技術(shù)產(chǎn)業(yè)等[2~5];在醫(yī)藥醫(yī)學(xué)領(lǐng)域也有廣泛應(yīng)用[6~8]。由于R

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