發(fā)布時(shí)間：2018-01-31 12:48

  本文關(guān)鍵詞： 熱浪 溫度驟降 Apo E~(-/-)小鼠 粘附因子 機(jī)理研究　出處：《南京信息工程大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：在全球氣候變暖的大背景下,南京市夏季高溫?zé)崂诉^程頻發(fā),心血管疾病發(fā)病和死亡率均有明顯增加。在熱浪影響心血管疾病研究方面,大多數(shù)研究者多采用流行病學(xué)統(tǒng)計(jì)方法,而針對熱浪過程誘發(fā)和加重心血管疾病的相關(guān)機(jī)制方面仍缺乏深入探討,且對熱浪的研究多局限于持續(xù)高溫的熱浪過程,對期間溫度驟降影響的研究較少涉及。因此,本項(xiàng)研究通過對南京市歷史氣象資料的統(tǒng)計(jì)分析,結(jié)合人群死亡資料,得到熱浪過程對心血管疾病的影響特征；在此基礎(chǔ)上,通過一次典型熱浪過程對動(dòng)物心血管疾病影響的實(shí)驗(yàn),探討熱浪過程誘發(fā)和導(dǎo)致患者死亡的機(jī)理。主要研究結(jié)論如下：(1)2005—2008年南京市夏季共發(fā)生8次熱浪過程,其中,持續(xù)高溫的熱浪過程及有降溫的熱浪過程各發(fā)生4次。死于心腦血管疾病的人數(shù)占總死亡人數(shù)的30%-40%。而熱浪過程期間死于心腦血管疾病的65歲及以上的老年人比例達(dá)73.96%。有強(qiáng)降溫發(fā)生的熱浪過程造成的死亡人數(shù)明顯多于持續(xù)高溫的熱浪過程。(2)小鼠受到熱刺激時(shí),HSP60及TNF-α、sICAM-1等炎性細(xì)胞因子顯著升高,使得體內(nèi)炎癥反應(yīng)加強(qiáng),SOD活性降低血脂升高,導(dǎo)致血管硬化發(fā)生發(fā)展,這可能是熱浪過程增加心血管病風(fēng)險(xiǎn)的一個(gè)誘因。(3)熱刺激會誘使機(jī)體炎癥標(biāo)志物水平顯著升高,可能會加重動(dòng)脈粥樣硬化疾病的發(fā)生發(fā)展,溫度驟降過程導(dǎo)致血管迅速收縮,將極大的促進(jìn)動(dòng)脈粥樣硬化的加重和血栓的形成,可能是導(dǎo)致最終心血管病發(fā)病和死亡的直接原因。
[Abstract]:In the background of global warming, Nanjing City summer heatwave process frequently, cardiovascular disease morbidity and mortality were significantly increased. In the heat effect of cardiovascular disease research, most researchers use epidemiological statistical methods, and according to the aspects of process and related mechanism of heat induced exacerbation of cardiovascular disease is the lack of in-depth discussion and research on the heat is limited to continuous high temperature heat process, study on the influence of the period of the temperature drop of the less involved. Therefore, this study based on the statistical analysis of historical meteorological data of Nanjing City, with the population of death data are characteristic of heat wave impact on cardiovascular disease; on this basis, through the influence of a typical process of heat cardiovascular disease animal experiments, to explore the process and mechanism of heat induced cause of death in patients. The main conclusions are as follows: (1) From 2005 to 2008 in Nanjing city in summer were 8 heatwave, the continuous high temperature heat process and cooling process of each heat occurred 4 times. Deaths from cardiovascular and cerebrovascular diseases accounted for the total number of deaths and the proportion of heat during the process of 30%-40%. died of cardiovascular disease at the age of 65 and the elderly have reached 73.96%. the number of deaths occurred in the process of strong cooling heat caused significantly more than the continuous high temperature heat process. (2) mice by thermally stimulated, HSP60 and TNF- alpha, sICAM-1 and other inflammatory cytokines increased significantly, the inflammatory reaction in vivo enhanced SOD activity decreased serum lipid levels, resulting in the development of vascular sclerosis, this may be a the heat process causes increased risk of cardiovascular disease. (3) will induce inflammatory markers significantly increased levels of heat stimulation may aggravate the occurrence and development of atherosclerotic disease, the temperature drop process The rapid contraction of blood vessels will greatly promote the aggravation of atherosclerosis and the formation of thrombosis, which may be the direct cause of the final occurrence and death of cardiovascular diseases.

【學(xué)位授予單位】：南京信息工程大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R122.26

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 朱衛(wèi)浩;張書余;田穎;羅斌;王寶鑒;;熱浪對ApoE基因缺陷小鼠ET-1、NO及體溫的影響[J];科學(xué)技術(shù)與工程;2013年16期

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本文編號：1479100