本文關(guān)鍵詞： 無細(xì)胞百白破聯(lián)合疫苗 加強(qiáng)免疫 免疫原性 水痘減毒活疫苗　出處：《中國疫苗和免疫》2017年02期 　論文類型：期刊論文

【摘要】：目的評(píng)價(jià)吸附無細(xì)胞百白破聯(lián)合疫苗(Diphtheria,tetanus and acellular pertussis combined vaccine,DTaP)加強(qiáng)免疫單獨(dú)接種和同時(shí)接種水痘減毒活疫苗(Varicella attenuated live vaccine,VarV)的免疫效果。方法選取滿18月齡且已完成DTaP基礎(chǔ)免疫的健康兒童218名,其中110人接種DTaP,108人同時(shí)接種DTaP和VarV。采用酶聯(lián)免疫吸附試驗(yàn)(Enzyme-linked immunosorbent assay,ELISA)檢測(cè)免疫前、后抗百日咳毒素抗體(Antibody to pertussis toxin,Anti-PT)、抗絲狀血凝素抗體(Antibody to filamentous hemagglutmin,Anti-FHA)、抗白喉毒素抗體(Antibody to diphtheria toxin,Anti-DT)和抗破傷風(fēng)毒素抗體(Antibody to tetanus toxin,Anti-TT),計(jì)算抗體幾何平均濃度(Geometric Mean Concentration,GMC)和抗體陽轉(zhuǎn)率(Seroconversion rate,SCR)。結(jié)果單獨(dú)接種組和同時(shí)接種組免疫后Anti-PT、Anti-FHA、Anti-DT和Anti-TT的SCR分別為43.64%、81.48%(x~2=33.26,P=0.000),72.73%、85.19%(x~2=0.84,P=0.358),90.00%、85.18%(x~2=1.16,P=0.281),13.64%、11.11%(x~2=0.32,P=0.571);GMC分別為94.74IU/ml、98.86IU/ml(t=1.15,P=0.251),39.59IU/ml、44.10IU/ml(t=1.90,P=0.059),1.89IU/ml、1.47IU/ml(t=3.83,P=0.000),3.85IU/ml、2.72IU/ml(t=5.51,P=0.000)。兩組Anti-PT、Anti-FHA免疫前陰性者免疫后SCR高于免疫前陽性者。同時(shí)接種組免疫后Anti-PT、Anti-FHA的GMC增長高于單獨(dú)接種組,而免疫后Anti-DT、Anti-TT的GMC增長低于單獨(dú)接種組。結(jié)論 DTaP加強(qiáng)免疫對(duì)預(yù)防百日咳的保護(hù)力有限,對(duì)預(yù)防白喉、破傷風(fēng)的加強(qiáng)免疫時(shí)間可以延長,同時(shí)接種DTaP和VarV對(duì)DTaP的免疫原性無影響。
[Abstract]:Objective to evaluate the adsorption of acellular diphtheria vaccine. Tetanus and acellular pertussis combined vaccine. DTaP) was immunized with varicella attenuated live vaccine and vaccinated with varicella attenuated live vaccine. Methods 218 healthy children over 18 months old who had completed the basic immunization of DTaP were selected and 110 of them were vaccinated with DTaP. Both DTaP and Varv.Enzyme-linked immunosorbent assay were detected by enzyme-linked immunosorbent assay (Elisa). Elisa was used to detect antibody to pertussis toxin anti-PTT before and after immunization. Antibody to filamentous hemagglutinin Anti-FHA. Antibody to diphtheria toxin. Anti-DT) and anti-tetanus toxin antibody Antibody to tetanus toxin Anti-TTT. Geometric Mean Concentration was calculated. GMC) and seroconversion rate were determined. Results Anti-PTT Anti-FHA was immunized only in the inoculation group and at the same time. The SCR of Anti-DT and Anti-TT were 43.64% and 72.73% respectively. 85.19 the ratio of 0.358U / 0.358U / 0.358U / 0.358U / t / 85.19 is 85.18 / 85.18 / 1.16 / 0.281 / 0.281 / 0.284% / 13.64% respectively. 11.11 0.32U 0.571C; The GMC was 94.74 IUU / ml and 98.86 IUP / ml respectively. 44.10 IUU / ml ~ (1.90) P ~ (0.059) ~ (1.89) ~ (?) ~ (1.47) ~ (?) ~ (3.83) ~ (?) ~ (0.000). 3.85IUP / ml 2.72IUP / ml 5.51Pu 0.000. two groups of Anti-PT. After immunization, the SCR of Anti-FHA negative group was higher than that of pre-immunization positive group, and the increase of GMC of Anti-PTT Anti-FHA was higher in the inoculation group than in the single inoculation group. But the increase of GMC in Anti-DTT Anti-TT after immunization was lower than that in single inoculation group. Conclusion the protective effect of DTaP on prevention of pertussis is limited and diphtheria can be prevented. The time of enhanced immunization of tetanus could be prolonged, and inoculation of DTaP and VarV had no effect on the immunogenicity of DTaP.
【作者單位】： 衢州市疾病預(yù)防控制中心;浙江省疾病預(yù)防控制中心;
【基金】：衢州市科技局項(xiàng)目(2015102)
【分類號(hào)】：R186
【正文快照】： 百日咳、白喉分別是由百日咳鮑特菌(Borde-tella pertussis)和白喉?xiàng)U菌(Bacillus diphtheria)感染引起的急性呼吸道傳染病,通過飛沫傳播,傳染性極強(qiáng)[1]。破傷風(fēng)是感染性細(xì)菌性疾病,由破傷風(fēng)痙攣毒素引發(fā)肌肉強(qiáng)直和痙攣,病死率較高,主要發(fā)生于不潔分娩和產(chǎn)后衛(wèi)生條件較差的新生

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