本文關(guān)鍵詞：廣西漢、壯、瑤族7、10、13歲學(xué)生IGFs水平及生長(zhǎng)發(fā)育影響因素的研究　出處：《廣西醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： IGFs 生長(zhǎng)發(fā)育 漢族 壯族 瑤族學(xué)生 影響因素

【摘要】：[目的]通過對(duì)廣西漢、壯、瑤族7歲、10歲、13歲學(xué)生的生長(zhǎng)發(fā)育影響因素進(jìn)行調(diào)查研究；了解廣西漢、壯、瑤族兒童的血清胰島素樣生長(zhǎng)因子-1（Insulin-like growth factor-1，IGF-1）、胰島素樣生長(zhǎng)因子結(jié)合蛋白-3（Insulin-like growth factor binding protein-3，IGFBP-3）水平，不同民族、性別IGF-1、IGFBP-3水平存在的差異，漢、壯、瑤族7歲、10歲、13歲學(xué)生生長(zhǎng)發(fā)育現(xiàn)狀，生長(zhǎng)發(fā)育水平存在的民族差異；探索影響兒童生長(zhǎng)發(fā)育、IGF-1水平、IGFBP-3水平的因素以及胰島素樣生長(zhǎng)因子（insulin-likegrowth factors，IGFs）對(duì)兒童生長(zhǎng)發(fā)育的影響作用；為今后進(jìn)一步開展研究、制定干預(yù)方案提供參考依據(jù)。 [方法]在廣西合浦縣、武鳴縣、恭城縣，分別抽取7歲、10歲和13歲的漢、壯、瑤族健康學(xué)生為研究對(duì)象。每個(gè)民族按各性別年齡組50人的標(biāo)準(zhǔn)抽樣，，最終選取了946名學(xué)生，7歲組男生156人，女生155人；10歲組男生157人，女生156人；13歲組男生161人，女生161人。對(duì)他（她）們進(jìn)行生長(zhǎng)發(fā)育調(diào)查，測(cè)定其形態(tài)、機(jī)能、素質(zhì)和性發(fā)育水平；在946名學(xué)生中以自愿為原則，抽取各性別年齡組30名學(xué)生作為IGFs和生長(zhǎng)發(fā)育影響因素調(diào)查對(duì)象，檢測(cè)標(biāo)本598人份，剔除偏離較大的標(biāo)本85人份，共占14.21%。實(shí)際采用檢測(cè)數(shù)據(jù)513人份，漢、壯、瑤族學(xué)生各性別年齡組樣本含量在22-35之間。 調(diào)查內(nèi)容包括形態(tài)指標(biāo)：身高、坐高、體重、胸圍；機(jī)能素質(zhì)指標(biāo)：肺活量、立定跳遠(yuǎn)、斜身引體（7、10歲男生）或引體向上（13歲男生）、一分鐘仰臥起坐（女生）；性發(fā)育指標(biāo)：男生睪丸體積、生殖器發(fā)育水平、女生乳房發(fā)育水平、陰毛發(fā)育水平；檢測(cè)和統(tǒng)計(jì)方法：采用ELISA法檢測(cè)漢、壯、瑤族學(xué)生IGF-1、IGFBP-3水平；對(duì)各項(xiàng)指標(biāo)進(jìn)行描述性分析，采用t檢驗(yàn)、方差分析、秩和檢驗(yàn)比較組間差異；分別以學(xué)生身高、體重為因變量，以父母身高、家庭經(jīng)濟(jì)狀況、出生時(shí)體重、豆類及豆制品攝入情況、體育運(yùn)動(dòng)時(shí)間、睡眠質(zhì)量、IGF-1水平、IGFBP-3水平等共30個(gè)指標(biāo)為自變量進(jìn)行多元線性逐步回歸分析。 [結(jié)果] 1IGF-1、IGFBP-3： （1）IGF-1水平：7歲、10歲、13歲組男生依次為117.98μg/L、111.75μg/L、149.28μg/L，女生依次為125.14μg/L、108.63μg/L、146.25μg/L；血清IGF-1水平13歲組最高，7歲組次之，10歲組最低。7歲組學(xué)生血清IGF-1水平壯族最高；10歲組血清IGF-1水平漢族和瑤族學(xué)生差異沒有統(tǒng)計(jì)學(xué)意義，壯族血清IGF-1水平最低；13歲組學(xué)生IGF-1水平壯族最高，瑤族次之，漢族最低。 （2）IGFBP-3水平：7歲、10歲、13歲組男生依次為62.42μg/L、61.74μg/L、61.27μg/L，女生依次為65.11μg/L、59.32μg/L、61.89μg/L；IGFBP-3水平年齡組間差異沒有統(tǒng)計(jì)學(xué)意義。7歲組IGFBP-3水平瑤族和壯族學(xué)生差異沒有統(tǒng)計(jì)學(xué)意義且均高于漢族學(xué)生；10歲組IGFBP-3水平瑤族學(xué)生最高，漢族最低；13歲組IGFBP-3水平漢族和瑤族學(xué)生差異沒有統(tǒng)計(jì)學(xué)意義，且均高于壯族學(xué)生。 2生長(zhǎng)發(fā)育 （1）形態(tài)指標(biāo)：壯族形態(tài)指標(biāo)發(fā)育水平均優(yōu)于漢族和瑤族學(xué)生。身高：7歲、10歲、13歲組男生平均值依次為122.11cm、138.03cm、154.16cm，女生依次為121.72cm、138.21cm、152.71cm；坐高：7歲、10歲、13歲組男生平均值依次為66.96cm、73.85cm、81.41cm，女生依次為66.70cm、73.87cm、82.11cm；體重：7歲、10歲、13歲組男生平均值依次為23.99Kg、33.20Kg、42.31Kg，女生依次為22.42Kg、31.10Kg、42.53Kg；胸圍：7歲、10歲、13歲組男生平均值依次為59.00cm、65.69cm、72.47cm，女生依次為57.49cm、64.63cm、73.50cm。 （2）機(jī)能素質(zhì)指標(biāo)：除13歲組男生引體向上、7歲組女生立定跳遠(yuǎn)、13歲組女生仰臥起坐不存在民族差異外，其余性別年齡組各項(xiàng)指標(biāo)均存在民族差異。肺活量：7歲、10歲、13歲組男生平均值依次為1310.60ml、1957.39ml、2865.88ml，女生依次為1180.36ml、1776.34ml、2383.11ml；立定跳遠(yuǎn)：7歲、10歲、13歲組男生平均值依次為119.06cm、148.81cm、194.41cm，女生依次為112.26cm、140.60cm、165.07cm；斜身引體/引體向上：7歲、10歲、13歲組男生平均值依次為8.71次、15.31次、5.12次；仰臥起坐：7歲、10歲、13歲組女生平均值依次為18.32次、27.05次、28.65次。 （3）身體指數(shù)：身高坐高指數(shù)僅7歲組學(xué)生存在民族差異。BMI指數(shù)僅10歲組男生存在民族差異；10歲組漢、壯、瑤族男生BMI指數(shù)依次為16.30kg/m2、18.40kg/m2、17.03kg/m2。壯族學(xué)生超重和肥胖發(fā)生率較高。肺活量體重指數(shù)7歲和10歲組漢族學(xué)生高于壯、瑤族學(xué)生，13歲組壯族男生最高為73.41ml/kg。 （4）性發(fā)育情況：男生生殖器發(fā)育水平僅13歲組有民族的差異，睪丸發(fā)育分期10歲和13歲組有差異。男生睪丸體積漢族7歲、10歲、13歲組均值依次為2.66ml、5.06ml、16.00ml；壯族依次為2.23ml、5.80ml、19.03ml；瑤族依次為2.93、4.23、10.44ml。女生乳房和陰毛發(fā)育在10歲、13歲組有民族差異。性發(fā)育分期皆為瑤族學(xué)生落后。 3影響因素分析3.1IGF-1、IGFBP-3水平影響因素 （1）影響IGF-1水平的因素有血清IGFBP-3水平、身高、牛奶或豆?jié){攝入情況、午睡情況、母親體重。 （2）影響IGFBP-3水平的因素有血清IGF-1水平、身高、牛奶或豆?jié){攝入情況、午睡情況、吃零食情況。 3.2生長(zhǎng)發(fā)育影響因素 （1）影響身高發(fā)育的因素有IGF-1水平、IGFBP-3水平、家庭人口、經(jīng)濟(jì)水平、是否挑食、吃早餐情況、平時(shí)是否喝牛奶或豆?jié){、主食量、青菜攝入情況、最后一節(jié)課饑餓感、每天戶外活動(dòng)的時(shí)間、夜晚睡眠時(shí)間。 （2）影響體重發(fā)育的因素有IGF-1水平、IGFBP-3水平、家庭人口、父親體重、出生體重、是否挑食、吃早餐情況、平時(shí)是否喝牛奶或豆?jié){、主食量、最后一節(jié)課饑餓感、午睡情況、夜晚睡眠時(shí)間。 [結(jié)論]身高、坐高、體重、胸圍、肺活量壯族學(xué)生最優(yōu)，立定跳遠(yuǎn)和仰臥起坐瑤族學(xué)生最優(yōu)，斜身引體漢族學(xué)生最優(yōu)，機(jī)能素質(zhì)水平與形態(tài)發(fā)育水平不協(xié)調(diào)；IGF-1水平和IGFBP-3水平互為影響因素，影響IGF-1水平和IGFBP-3水平的因素除身高、牛奶或豆?jié){攝入情況、午睡情況外，母親體重對(duì)IGF-1水平亦有影響，吃零食情況對(duì)IGFBP-3水平也有影響；身高、體重發(fā)育的影響因素除血清IGF-1、IGFBP-3水平外，營(yíng)養(yǎng)、運(yùn)動(dòng)和睡眠狀況亦包括其中，但民族因素沒有入選。應(yīng)進(jìn)一步分析和驗(yàn)證血清IGF-1、IGFBP-3水平與生長(zhǎng)發(fā)育的相關(guān)關(guān)系，血清IGF-1、IGFBP-3水平的影響因素；根據(jù)影響漢、壯、瑤族學(xué)生生長(zhǎng)發(fā)育的因素采取措施促進(jìn)漢、壯、瑤族學(xué)生體質(zhì)均衡發(fā)展，
[Abstract]:[Objective] by Guangxi Han Zhuang, Yao, 7 years old, 10 years old, to investigate the influencing factors on the growth of 13 year olds; understand the Guangxi Han, Zhuang, Yao children's serum insulin-like growth factor -1 (Insulin-like growth factor-1, IGF-1), insulin-like growth factor binding protein -3 (Insulin-like growth factor binding protein-3, IGFBP-3) level, different nationalities, gender differences, IGF-1, IGFBP-3 level in the presence of the Han, Zhuang, Yao, 7 years old, 10 years old, 13 years of growth and development status of students, ethnic differences in level of growth and development; to explore the influence of children's growth and development, the level of IGF-1, factor IGFBP-3 levels and insulin like growth factor (insulin-likegrowth factors, IGFs) on the growth and development of children; for further study, to provide reference for the intervention.
[method] in Guangxi Hepu County, Wuming County, Gongcheng County, were selected at the age of 7, 10 and 13 year old Han, Zhuang, Yao students as the research object. According to the national standard sample of each sex age group 50, the final selection of 946 students, 7 year old group of 156 boys and girls 155 people; 10 years old group, 157 boys, 156 girls; 13 year old group of 161 boys and 161 girls. He (she) who investigated the growth, determination of the form, function, quality and development level; the 946 students voluntarily, from each sex age group 30 students as IGFs and growth factors survey, test specimens of 598 Cases, excluding the deviation specimens of 85 cases, accounted for 14.21%. the actual test data of 513 people, Han, Zhuang, Yao students in each gender and age group samples were between 22-35.
The survey includes morphological indicators: height, sitting height, body weight, chest circumference; function of quality indicators: vital capacity, standing long jump, pull (7,10 year old male) or chinning (13 boys), one minute sit ups (female); sexual development index: male testicular volume, genital development level, the development level of breast girls, pubic hair development level; detection and statistical methods: ELISA method was used to detect the Han, Zhuang, Yao students IGF-1, IGFBP-3 level; descriptive analysis of the indicators, using t test, analysis of variance, the difference between the groups with rank sum test; students' height, weight as the dependent variable, with the height of parents, family economic the status, birth weight, beans and bean products intake, physical exercise, sleep quality, IGF-1 level, IGFBP-3 level of a total of 30 indicators as independent variables stepwise multiple linear regression analysis.
[results]
1IGF-1, IGFBP-3:
The level of IGF-1 (1): 7 years old, 10 years old, 13 years old group of boys were 117.98 g/L, 111.75 g/L, 149.28 g/L, girls were 125.14 g/L, 108.63 g/L, 146.25 g/L; serum IGF-1 level is the highest 13 years old group, 7 years old group, 10 years old.7 years old was the lowest. The serum level of IGF-1 group of students at the age of 10 the highest Zhuang; levels of IGF-1 in Han and Yao students there is no significant difference in serum IGF-1 level, minimum 13 years old group of students of Zhuang nationality; the IGF-1 level of the highest Zhuang, Yao, Han minimum.
The level of IGFBP-3 (2): 7 years old, 10 years old, 13 years old group of boys were 62.42 g/L, 61.74 g/L, 61.27 g/L, girls were 65.11 g/L, 59.32 g/L, 61.89 g/L; differences in the level of IGFBP-3 between age groups was not statistically significant.7 age group IGFBP-3 Yao and Zhuang Students differences no statistically significant and were higher than Han students; minimum 10 years old group IGFBP-3 Han Yao students; the highest level, 13 year old group IGFBP-3 level of Han and Yao students the difference was not statistically significant, and higher than that of students of Zhuang nationality.
2 growth and development
(1) morphological index: Zhuang morphological development indicators were better than those of Han and Yao students. Height: 7 years old, 10 years old, 13 year old male group average value were 122.11cm, 138.03cm, 154.16cm, 138.21cm, 121.72cm were female, 152.71cm; sitting height: 7 years old, 10 years old, 13 year old male group mean life the order of 66.96cm, 73.85cm, 81.41cm, 73.87cm, 66.70cm were female, 82.11cm; weight: 7 years old, 10 years old, 13 year old male group average value were 23.99Kg, 33.20Kg, 42.31Kg, 31.10Kg, 22.42Kg were female, 42.53Kg; chest: 7 years old, 10 years old, 13 years old group of boys are average 59.00cm, 65.69cm, 72.47cm, 64.63cm, 57.49cm were female, 73.50cm.
(2) the function of quality index: in 13 years old group of boys pull-up, 7 year old girl standing long jump, 13 groups of girls sit ups does not exist ethnic differences, the rest of the index of sex and age groups were ethnic differences. Capacity: 7 years old, 10 years old, 13 year old male group average value were 1310.60ml, 1957.39ml girls, 2865.88ml, followed by 1180.36ml, 1776.34ml, 2383.11ml; standing long jump: 7 years old, 10 years old, 13 year old male group average value were 119.06cm, 148.81cm, 194.41cm, 140.60cm, 112.26cm were female, 165.07cm; pull / pull ups: 7 years old, 10 years old, 13 year old boys group average in order for 8.71 times, 15.31 times, 5.12 times; sit ups: 7 years old, 10 years old, 13 year old girl group average were 18.32 times, 27.05 times, 28.65 times.
(3) the body index: sitting height index is only 7 years old group of students from different nationalities.BMI index are different between only 10 boys; 10 year old group of Han, Zhuang, Yao boys BMI index were 16.30kg/m2,18.40kg/m2,17.03kg/m2. students of Zhuang Nationality in the incidence of overweight and obesity is higher. Lung weight index of 7 and 10 years old Han group the student is higher than that of Zhuang, Yao students, 13 year old Zhuang group was the highest 73.41ml/kg. boys
(4) sexual development: male genital development level of ethnic differences is only 13 years old group, 10 stage and 13 year old group differences in testicular development. Male testicular volume 10, Han 7 years old, mean 13 years old group were 2.66ml, 5.06ml, 16.00ml; Zhuang were 2.23ml, 5.80ml, 19.03ml; Yao in order for the 2.93,4.23,10.44ml. female breast and pubic hair development in 10 years, 13 year old group of ethnic differences. Development stages are Yao students behind.
3 influencing factors analysis 3.1IGF-1, IGFBP-3 level influence factors
(1) the factors affecting the IGF-1 level were serum IGFBP-3 level, height, milk or soybean milk intake, nap, mother weight.
(2) the factors affecting the IGFBP-3 level were serum IGF-1 level, height, milk or soybean milk intake, nap situation, and snack condition.
3.2 influence factors of growth and development
(1) the factors that affect height development include IGF-1 level, IGFBP-3 level, family population, economic level, whether picky food, breakfast, milk or soybean milk, main food intake, greens intake, last class hunger, daily outdoor activities and night sleep time.
(2) the factors that affect weight development include IGF-1 level, IGFBP-3 level, family weight, father weight, birth weight, whether to be choosy, breakfast, milk or soy milk, main food, hunger, nap and sleep time.
[Conclusion] the height, sitting height, body weight, chest circumference, vital capacity of Zhuang Students best, standing long jump and sit up Yao students optimal pull Han students optimal function level and morphological development level is not coordinated; IGF-1 level and IGFBP-3 level are influencing factors, the influence factors of the IGF-1 and IGFBP-3 level in addition to height, milk or Soybean Milk intake, napping, maternal weight also has influence on the level of IGF-1, eat snacks also have influence on the level of IGFBP-3; influence factors of height, weight development in serum IGF-1, IGFBP-3 level, nutrition, exercise and sleep status also included, but not included in national factors should be further analyzed and verified. Correlation between serum IGF-1, IGFBP-3 levels and growth of serum IGF-1, the effect factors of IGFBP-3; according to the influence of Han, Zhuang, Yao students growth factors to take measures To promote the balanced development of the physique of the Han, Zhuang and Yao students.

【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R179

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