本文關(guān)鍵詞：中藥藥效評價的“水閘門”法，，由筆耕文化傳播整理發(fā)布。

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摘要：

疾病是由于各種致病因素的綜合致病力超過了人體免疫力，并達(dá)到發(fā)病閾值以上的結(jié)果�；瘜W(xué)藥品一般作用于疾病的某一發(fā)病環(huán)節(jié)，阻斷病理過程，達(dá)到治療疾病的目的。利用不同的藥物作用于疾病的不同環(huán)節(jié)上，使綜合致病力降低到疾病發(fā)病的閾值以下，使人體的免疫力足以對抗致病力時，疾病就能得以控制，達(dá)到治療的目的。為了評價多種藥物對疾病不同環(huán)節(jié)的綜合作用，本文提出了用“水閘門”評價的一般方法，該方法把病理過程的各個階段分為順式途徑和旁路途徑兩種，并初步提出了兩個數(shù)學(xué)模型，以期說明用若干中等作用強(qiáng)度的藥物對疾病各環(huán)節(jié)的阻斷而達(dá)到的治療效果，并不一定弱于那些對單靶點有高強(qiáng)度作用的藥物的治療作用。從而說明中藥和中藥復(fù)方中多種成分對疾病發(fā)病過程的不同環(huán)節(jié)或不同的靶點作用的綜合性，解釋中藥或中藥復(fù)方藥效的科學(xué)內(nèi)涵。

關(guān)鍵詞： 病理環(huán)節(jié)   順式途徑   旁路途徑   中藥   水閘門評價方法  

基金：

Abstract：

Diseases were the results of total nosogeneses exceeding over limit level of the human immunity Chemical medicine usually acts on the key enzyme or receptor in the pathological processes and cuts off the pathological process to stop the disease Drugs, acting on different pathological targets of a disease, could synengetically increase the effects of drugs while used together, and dealase the total nosogenetic power below the limit level of falling ill, i. e. whill immunity is over the nosogenetic power in human body, the disease could be inhibited or cured. To evaluate the total effect of multi - drugs acting on different targets of human body and explore the scientific connotation of traditional Chinese herbs and their combination, a method, named floodgate evaluation method, was set up Paths of pathological processes could be classified into two type sequence path and bypass path To evaluate total parallel effecting ratio of multicomponents in herbal medicine which acting on the sequence paths and bypass, the calculated expression formula were showed as in expression 1 and 2. This two simple mathematical models indicate that the total curative effect of multi - compounds in herbal medicine, due to different compounds acting on different targets with mild strength for certain targets in the pathological processes of a disease, exceed over than that of single drug or compound having very high strength for one target. The scientific background of traditional Chinese herbal medicine, contained different type compounds, to cure the disease, probably due to the comprehensive effects Of these compounds producing synergic roles upon multi - pathological targets of disease.

Keywords： Parallel path   Floodgate evaluation method   Sequence path   Pathology   Traditional Chinese herbal medicine  

  本文關(guān)鍵詞：中藥藥效評價的“水閘門”法，由筆耕文化傳播整理發(fā)布。