【摘要】：目的探討咽喉反流(laryngopharyngeal reflux,LPR)與嗓音疾病的相關(guān)關(guān)系。方法對(duì)103例疑有LPR相關(guān)癥狀的成年患者行反流癥狀指數(shù)量表(reflux symptom index,RSI)、反流體征計(jì)分量表(reflux finding score,RFS)、24小時(shí)雙探頭食管pH值監(jiān)測(cè),其中伴有嗓音疾病患者89例,分別為聲帶接觸性肉芽腫組18例,慢性喉炎組19例,聲帶息肉組15例,聲帶白斑組21例,聲帶任克水腫組16例,余14例無(wú)嗓音疾病(對(duì)照組)。結(jié)果 103例患者中診斷為L(zhǎng)PR的陽(yáng)性率為46.6%(48/103),89例嗓音疾病患者LPR陽(yáng)性率為48.30%(43/89),其中聲帶任克水腫組LPR陽(yáng)性率(75%,12/16)、聲帶白斑組LPR陽(yáng)性率(71.4%,15/21)顯著高于對(duì)照組(35.7%,5/14)(P=0.030,P=0.036)。慢性喉炎組、聲帶任克水腫組RSI得分(13.5±7.2、13.9±2.3分)顯著高于對(duì)照組(9.1±2.9分)(P=0.019,P=0.020);聲帶任克水腫組RFS得分(12.6±2.9分)顯著高于對(duì)照組(7.6±2.9分)(P=0.009)。聲帶白斑組立位酸反流次數(shù)、臥位酸反流次數(shù)、總酸反流次數(shù)、立位酸反流時(shí)間、總酸反流時(shí)間顯著高于對(duì)照組(P=0.011,P=0.004,P=0.015,P=0.034,P=0.027);聲帶任克水腫組立位酸反流次數(shù)、總酸反流次數(shù)、立位酸暴露百分比、總酸暴露百分比、立位酸反流時(shí)間、總酸反流時(shí)間顯著高于對(duì)照組(P=0.025,P=0.039,P=0.041,P=0.030,P=0.012,P=0.011)。結(jié)論聲帶白斑、聲帶任克水腫與LPR相關(guān)性較高,兩種疾病患者的咽喉部24小時(shí)食管pH值監(jiān)測(cè)表現(xiàn)為反流次數(shù)多、時(shí)間長(zhǎng)。
[Abstract]:Objective to investigate the relationship between throat reflux (laryngopharyngeal reflux,LPR) and voice diseases. Methods the reflux symptom index scale (reflux symptom index,RSI), reverse fluid symptom scale (reflux finding score,RFS) and 24-hour double probe esophageal pH monitoring were performed in 103 adult patients with suspected LPR-related symptoms, including 89 patients with voice diseases, 18 patients with vocal cord contact granuloma, 19 patients with chronic laryngitis, 15 patients with vocal cord polyps, 21 patients with vocal cord leukoplakia and 16 patients with vocal cord Ren Ke edema group, including 18 patients with vocal cord contact granuloma, 19 patients with chronic laryngitis, 15 patients with vocal cord polyp, 21 patients with vocal cord leukoplakia and 16 patients with vocal cord renker edema group. The remaining 14 cases had no voice disease (control group). Results the positive rate of LPR was 46.6% (48 / 103) in 103 patients and 48.30% (43 鹵89) in 89 patients with voice disease. The positive rate of LPR in vocal cord edema group (75%, 12: 16) and vocal cord leukoplakia group (71.4%, 15 鹵21) were significantly higher than those in control group (35.7%, 5 鹵14) (P 鈮，

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