【摘要】：目的:探討鼻淵通竅顆粒對兒童慢性鼻竇炎患者的臨床療效及作用機制。方法:將120例患者隨機按數(shù)字法分為對照組和觀察組各60例。對照組采用阿莫西林克拉維酸鉀干混懸劑,4~7歲,1包/次,2次/d,7~12歲,1.5包/次,2次/d。療程4周。氨溴索顆粒,1.2~1.6 mg·kg-1,分2~3次口服,療程6周。標(biāo)準(zhǔn)桃金娘油腸溶膠囊(兒童裝),120 mg/次,3次/d。療程6周。觀察組在對照組治療的基礎(chǔ)上加鼻淵通竅顆粒,5~10 g/次,3次/d。療程6周。檢測鼻黏膜纖毛傳輸時間(MTT);檢測血清白細胞介素-2(IL-2)和白細胞介素-6(IL-6)水平;進行鼻內(nèi)鏡檢查,采用Lund-Kennedy評分法評價結(jié)果;記錄治療前后主要癥狀、體征評分。結(jié)果:觀察組疾病療效總有效率95%,對照組81.7%,觀察組優(yōu)于對照組(P0.05);治療后觀察組IL-2和IL-6水平低于對照組(P0.01);治療后3個月觀察組MTT及Lund-Kennedy評分低于對照組(P0.01);治療后觀察組鼻塞、流膿涕、頭痛、嗅覺減退、回吸痰、鼻黏膜充血腫脹等癥狀、體征評分均低于對照組(P0.01)。結(jié)論:鼻淵通竅顆粒能抑制兒童慢性鼻竇炎患者促炎因子,促進鼻黏膜纖毛功能,改善患者臨床癥狀、體征,臨床有一定療效。
[Abstract]:Objective: to investigate the clinical effect and mechanism of Biyuan Tongqiao granule on children with chronic sinusitis. Methods: 120 patients were randomly divided into two groups: control group (n = 60) and observation group (n = 60). The control group was treated with amoxicillin-clavulanate potassium dry suspension, 4 years old, 1 pack per day, 2 times per day, 7-day-old, 12-year-old, 1.5 packets / time, 2 times / d. The course of treatment was 4 weeks. Ambroxol granules, 1.2? 1.6 mg kg-1, were given 3 times for 6 weeks. Standard Taojinniang oil enteric-soluble capsule (children's suit), 120 mg/ times, 3 times / d. The course of treatment was 6 weeks. In the observation group, on the basis of the treatment of the control group, Biyuan Tongqiao granule was added, 5 g / time, 3 times / d. The course of treatment was 6 weeks. The levels of serum interleukin-2 (IL-2) and interleukin-6 (IL-6) were detected by (MTT);, the nasal endoscopy was performed, and the results were evaluated by Lund-Kennedy scoring method, and the levels of serum interleukin-2 (IL-2) and interleukin-6 (IL-6) were measured by RT-PCR. The main symptoms and signs were recorded before and after treatment. Results: the total effective rate was 95% in the observation group and 81.7% in the control group, which was better than that in the control group (P0.05), and the levels of IL-2 and IL-6 in the observation group were lower than those in the control group (P0.01). The scores of MTT and Lund-Kennedy in the observation group were lower than those in the control group 3 months after treatment (P0.01). After treatment, the symptoms such as nasal congestion, runny pus, headache, anosmia, expectoration, congestion and swelling of nasal mucosa in the observation group were lower than those in the control group (P0.01). Conclusion: Biyuan Tongqiao granule can inhibit the proinflammatory factors in children with chronic sinusitis, promote the ciliate function of nasal mucosa, improve the clinical symptoms and signs of the patients, and have a certain clinical effect.
【作者單位】： 鄭州大學(xué)第一附屬醫(yī)院;
【基金】：國家自然科學(xué)基金項目(2010A320020)
【分類號】：R765.41

【參考文獻】

相關(guān)期刊論文 前6條

1 許庚,史劍波,文衛(wèi)平;兒童鼻竇炎規(guī)范化診斷和治療[J];中國耳鼻咽喉頭頸外科;2005年07期

2 樊賢超;牛崇峰;;鼻淵通竅顆�？寡鬃饔脤嶒炑芯縖J];中醫(yī)藥導(dǎo)報;2010年03期

3 陳遠惠;;中西醫(yī)結(jié)合治療小兒慢性鼻竇炎300例療效觀察[J];中國醫(yī)藥指南;2008年23期

4 王涂路;馮娟;;蒼耳子散加減內(nèi)服及薰鼻對慢性鼻竇炎內(nèi)窺鏡術(shù)后的臨床療效[J];中國實驗方劑學(xué)雜志;2012年12期

5 范紹，

本文編號：2471110