【摘要】：目的探討全反式維甲酸(ATRA)對(duì)兔后發(fā)性白內(nèi)障的抑制作用。方法將12只健康家兔(24只眼)隨機(jī)分為眼用平衡鹽液組(空白對(duì)照組)和ATRA組(藥物實(shí)驗(yàn)組),每組6只兔(12只眼),在全麻下進(jìn)行透明晶狀體囊外摘除術(shù)。分別于術(shù)后1、3、7、14、30和60 d對(duì)術(shù)眼進(jìn)行裂隙燈和眼底檢查,并抽取房水置于-80℃保存。用酶聯(lián)免疫吸附測(cè)定術(shù)后兔眼房水中的白細(xì)胞介素-1β(IL-1β)和轉(zhuǎn)化生長因子-β(TGF-β)的含量。3月后處死動(dòng)物,分別對(duì)兩組兔眼進(jìn)行組織病理學(xué)及電鏡觀察。結(jié)果術(shù)后房水中IL-1β和TGF-β含量實(shí)驗(yàn)組明顯低于對(duì)照組(P0.001)。術(shù)后3月實(shí)驗(yàn)組晶體后囊透明度優(yōu)于對(duì)照組(P0.05)。對(duì)照組晶體后囊前覆蓋一層晶體上皮細(xì)胞,實(shí)驗(yàn)組晶體后囊前無明顯晶體上皮細(xì)胞增殖。結(jié)論 ATRA可抑制房水中IL-1β和TGF-β的含量,能夠有效抑制后發(fā)性白內(nèi)障的發(fā)生。
[Abstract]:Objective to investigate the inhibitory effect of all-trans retinoic acid (ATRA) on posterior cataract in rabbits. Methods Twelve healthy rabbits (24 eyes) were randomly divided into two groups: eye balanced saline group (blank control group) and ATRA group (drug experimental group). Six rabbits (12 eyes) in each group were treated with extracapsular extraction of transparent lens under general anesthesia. The eyes were examined with slit lamp and fundus at 1, 3, 7, 14, 30 and 60 days after operation, and the aqueous humor was stored at-80 鈩，

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