【摘要】：目的探討早期青光眼患者不同類型視盤的視網膜神經纖維層(retinal nerve fiber layer,RNFL)厚度,以了解不同類型視盤的早期青光眼患者的RNFL厚度的特點。方法應用光學相干斷層掃描(optical coherence tomography,OCT)技術檢查視盤RNFL厚度,將收集到的OCT視盤檢查結果分為6組:對照組大視盤組、中視盤組、小視盤組,每組各20眼,早期青光眼大視盤組、中視盤組、小視盤組各20眼。OCT測量120眼各鐘點平均RNFL厚度。檢測對照組和早期青光眼患者12個鐘位的視盤RNFL厚度。結果對照組不同類型視盤組的RNFL厚度曲線均在下方和上方形成雙峰,在鼻側和顳側形成波谷,各組下方峰均高于上方峰。其中大視盤組患者RNFL厚度(105.60±5.87)μm,其次是中視盤組(107.05±7.29)μm和小視盤組(108.40±7.27)μm。對照組大、中、小視盤組的RNFL厚度差異無統(tǒng)計學意義(P0.05)。早期青光眼RNFL厚度曲線的上或下方峰值降低,但仍然具備上、下方的雙峰特征,各組的下方峰皆高于上方峰。其中大視盤組患者RNFL厚度最薄(70.25±14.71)μm,其次是中視盤組(85.55±15.39)μm和小視盤組(87.55±9.46)μm,大視盤組與中視盤組、小視盤組的視盤RNFL厚度的差異有統(tǒng)計學意義(均為P0.05),中視盤組與小視盤組的RNFL厚度差異無統(tǒng)計學意義(P0.05)。早期青光眼患者與對照組不同類型視盤的RNFL均為厚度差異均有統(tǒng)計學意義(均為P0.05)。結論對照組不同大小的視盤并不影響RNFL厚度,早期青光眼患者視盤的RNFL厚度明顯變薄,但仍然具備上、下方的雙峰特征,各組的下方峰皆高于上方峰,其中大視盤患者的RNFL比中、小視盤受損更嚴重。
[Abstract]:Objective to investigate the thickness of retinal nerve fiber layer (retinal nerve fiber layer,RNFL) of different types of optic disc in patients with early glaucoma, so as to understand the characteristics of RNFL thickness in patients with different types of optic disc. Methods the optical coherence tomography (optical coherence tomography,OCT) technique was used to examine the RNFL thickness of optic disc. The results of OCT disc examination were divided into 6 groups: large optic disc group, middle optic disc group, small optic disc group, 20 eyes in each group, and 20 eyes in each group. The average RNFL thickness was measured by Oct in 20 eyes of the large optic disc group, 20 eyes of the middle optic disc group and 20 eyes of the small optic disc group. The RNFL thickness of optic disc was measured at 12 hours in control group and early glaucoma patients. Results the RNFL thickness curves of the different types of optic disc group in the control group formed double peaks below and above, and the nasal and temporal valleys were formed in the nasal and temporal sides. The lower peaks in each group were higher than those in the upper ones. The thickness of RNFL was (105.60 鹵5.87) 渭 m in the large disc group, (107.05 鹵7.29) 渭 m in the middle optic disk group and (108.40 鹵7.27) 渭 m in the small disc group. There was no significant difference in the thickness of RNFL between the large, medium and small disc groups in the control group (P0.05). The upper and lower peaks of RNFL thickness curve in early glaucoma decreased, but they still had the characteristics of upper and lower double peaks. The lower peak was higher than the upper peak in each group. The thickness of RNFL was the thinnest (70.25 鹵14.71) 渭 m in the large disc group, (85.55 鹵15.39) 渭 m in the middle optic disk group, (87.55 鹵9.46) 渭 m in the small optic disk group, (87.55 鹵9.46) 渭 m in the small optic disk group, and (70.25 鹵14.71) 渭 m in the large optic disk group and in the middle optic disk group. There was significant difference in the thickness of RNFL between the small disc group and the small disc group (P 0.05), but there was no significant difference in the RNFL thickness between the medium disc group and the small disc group (P0.05). The RNFL thickness of different types of optic disc in patients with early glaucoma was significantly different from that in control group (P 0.05). Conclusion the optic disc of different sizes in the control group has no effect on the thickness of RNFL. The thickness of RNFL in the optic disc of early glaucoma patients is obviously thinner, but it still has the characteristics of upper and lower double peaks, and the lower peak of each group is higher than the upper peak. The RNFL of the patients with large disc was more severe than that of the small disc.
【作者單位】： 首都醫(yī)科大學附屬北京朝陽醫(yī)院眼科;
【分類號】：R775

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