布地奈德混懸液在內(nèi)鏡鼻竇手術(shù)后運(yùn)用的臨床研究
發(fā)布時(shí)間:2019-02-09 15:14
【摘要】:目的:觀察布地奈德混懸液浸潤(rùn)明膠海綿片在慢性鼻-鼻竇炎、鼻息肉患者內(nèi)鏡鼻竇手術(shù)后創(chuàng)面局部使用是否能有效減少囊泡形成、促進(jìn)黏膜上皮化和改善鼻腔癥狀。 方法:選取2009年9月至2010年12月在昆明醫(yī)學(xué)院第一附屬醫(yī)院耳鼻咽喉科住院接受內(nèi)鏡鼻竇手術(shù)治療的慢性鼻一鼻竇炎、鼻息肉患者72例,按病變嚴(yán)重程度進(jìn)行分型為Ⅰ型、Ⅱ型和Ⅲ型,再根據(jù)變應(yīng)性因素,年齡情況行實(shí)驗(yàn)組和對(duì)照組1:1配對(duì)設(shè)計(jì)。術(shù)前所有患者行鼻部癥狀視覺模擬量化(VAS)評(píng)分,Lund-Mackay評(píng)分;術(shù)后隨訪換藥于鼻黏膜的轉(zhuǎn)歸競(jìng)爭(zhēng)期中,給予實(shí)驗(yàn)組患者布地奈德混懸液浸潤(rùn)明膠海綿片行創(chuàng)面局部濕敷至鼻黏膜上皮化為止,對(duì)照組按常規(guī)換藥隨訪治療。觀察對(duì)照組和實(shí)驗(yàn)組上皮化時(shí)間,6個(gè)月時(shí)進(jìn)行VAS癥狀評(píng)分和Lund-Kennedy內(nèi)鏡評(píng)分,然后將實(shí)驗(yàn)組和對(duì)照組的評(píng)分及上皮化時(shí)間做臨床統(tǒng)計(jì)學(xué)分析,比較兩者之間的差異性。 結(jié)果:1.術(shù)前VAS癥狀評(píng)分,Lund-MackayCT評(píng)分三個(gè)型別中實(shí)驗(yàn)組和對(duì)照組間差異無統(tǒng)計(jì)學(xué)意義(P0.05),術(shù)前齊同性較好;2.術(shù)后Ⅰ型患者實(shí)驗(yàn)組和對(duì)照組VAS癥狀評(píng)分比較差異無統(tǒng)計(jì)學(xué)意義(P0.05),Ⅱ型和Ⅲ型患者實(shí)驗(yàn)組和對(duì)照組VAS評(píng)分比較差異有統(tǒng)計(jì)學(xué)意義(P0.05);三個(gè)型別實(shí)驗(yàn)組和對(duì)照組患者上皮化時(shí)間及Lund-Kennedy內(nèi)鏡評(píng)分比較差異有統(tǒng)計(jì)學(xué)意義(P0.05);Ⅱ型和Ⅲ型實(shí)驗(yàn)組的鼻腔癥狀改善較對(duì)照組好,三個(gè)型別中實(shí)驗(yàn)組上皮化時(shí)間較對(duì)照組縮短;3.使用過程中未見明顯糖皮質(zhì)激素的不良反應(yīng)。 結(jié)論:慢性鼻-鼻竇炎、鼻息肉患者,內(nèi)鏡鼻竇手術(shù)后用布地奈德混懸液浸潤(rùn)明膠海綿片在鼻腔鼻竇術(shù)腔創(chuàng)面局部濕敷,配合鼻內(nèi)糖皮質(zhì)激素噴鼻、生理鹽水鼻腔沖洗、口服大環(huán)內(nèi)酯類藥物及定期隨訪等治療,可以明顯改善鼻腔癥狀、減少術(shù)腔創(chuàng)面囊泡形成、促進(jìn)鼻黏膜上皮生長(zhǎng)和縮短上皮化時(shí)間。方法經(jīng)濟(jì)且簡(jiǎn)便易行,可以在成年患者中推薦使用。
[Abstract]:Objective: to observe whether budesonide suspension infiltrating gelfoam sponge can effectively reduce vesicle formation, promote mucosal epithelization and improve nasal symptoms in patients with chronic rhinosinusitis and nasal polyps. Methods: from September 2009 to December 2010, 72 patients with chronic rhinosinusitis and nasal polyps who were admitted to the Department of Otorhinolaryngology, first affiliated Hospital of Kunming Medical College, received endoscopic sinus surgery, were classified as type 鈪,
本文編號(hào):2419089
[Abstract]:Objective: to observe whether budesonide suspension infiltrating gelfoam sponge can effectively reduce vesicle formation, promote mucosal epithelization and improve nasal symptoms in patients with chronic rhinosinusitis and nasal polyps. Methods: from September 2009 to December 2010, 72 patients with chronic rhinosinusitis and nasal polyps who were admitted to the Department of Otorhinolaryngology, first affiliated Hospital of Kunming Medical College, received endoscopic sinus surgery, were classified as type 鈪,
本文編號(hào):2419089
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