HB-EGF在原發(fā)性翼狀胬肉中的表達(dá)及意義
發(fā)布時間:2019-01-28 23:06
【摘要】:目的: 研究HB-EGF在原發(fā)性翼狀胬肉頭部、體部和正常結(jié)膜中的表達(dá)情況,探討其與翼狀胬肉發(fā)病之間的關(guān)系。 方法: 采用免疫組化和Western Blotting方法研究HB-EGF分別在28例原發(fā)性翼狀胬肉的頭部、體部與8例正常結(jié)膜組織的表達(dá)。 結(jié)果: 免疫組化的結(jié)果:HB-EGF在28例原發(fā)性翼狀胬肉頭部、體部及8例正常結(jié)膜中均有表達(dá),經(jīng)過單因方差分析翼狀胬肉頭部組陽性表達(dá)高于體部組(P0.05),體部組陽性表達(dá)高于正常結(jié)膜組(P0.05)。頭部組陽性表達(dá)顯著高于正常結(jié)膜組(P0.01)。 Western Blotting的結(jié)果:HB-EGF在原發(fā)性翼狀胬肉頭部、體部和正常結(jié)膜中均有表達(dá)。HB-EGF在翼狀胬肉的頭部的表達(dá)強度最強,體部次之,正常結(jié)膜表達(dá)最弱。經(jīng)過單因方差分析翼狀胬肉頭部陽性表達(dá)高于體部(P0.05),體部組陽性表達(dá)高于正常結(jié)膜組(P0.05)。頭部陽性表達(dá)顯著高于正常結(jié)膜(P0.01)。 結(jié)論: 1.HB-EGF在原發(fā)性翼狀胬肉組織中的高表達(dá),提示它參與了翼狀胬肉的發(fā)生與發(fā)展。 2.HB-EGF在原發(fā)性翼狀胬肉頭部表達(dá)強于體部,提示其在翼狀胬肉中發(fā)揮作用的部位主要在翼狀胬肉的頭部。
[Abstract]:Aim: to study the expression of HB-EGF in the head, body and normal conjunctiva of primary pterygium, and to explore the relationship between the expression of HB-EGF and the pathogenesis of pterygium. Methods: immunohistochemical and Western Blotting methods were used to study the expression of HB-EGF in 28 cases of pterygium head, body and 8 cases of normal conjunctiva. Results: HB-EGF was expressed in 28 cases of primary pterygium head, body and 8 cases of normal conjunctiva. The positive expression of HB-EGF in pterygium head group was higher than that in body group after ANOVA (P0.05). The positive expression in body group was higher than that in normal conjunctiva group (P0.05). The positive expression in head group was significantly higher than that in normal conjunctiva group (P0.01). The results of Western Blotting showed that HB-EGF was expressed in primary pterygium head, body and normal conjunctiva. HB-EGF expression was the strongest in pterygium head, second in body and weakest in normal conjunctiva. The positive expression of pterygium head was higher than that of body part (P0.05), and the positive expression of body group was higher than that of normal conjunctiva group (P0.05). The positive expression of head was significantly higher than that of normal conjunctiva (P0.01). Conclusion: the overexpression of 1.HB-EGF in primary pterygium suggests that it is involved in the occurrence and development of pterygium. The expression of 2.HB-EGF in primary pterygium was stronger than that in body, suggesting that the role of 2.HB-EGF in pterygium was mainly in the head of pterygium.
【學(xué)位授予單位】:南昌大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2011
【分類號】:R777.33
本文編號:2417399
[Abstract]:Aim: to study the expression of HB-EGF in the head, body and normal conjunctiva of primary pterygium, and to explore the relationship between the expression of HB-EGF and the pathogenesis of pterygium. Methods: immunohistochemical and Western Blotting methods were used to study the expression of HB-EGF in 28 cases of pterygium head, body and 8 cases of normal conjunctiva. Results: HB-EGF was expressed in 28 cases of primary pterygium head, body and 8 cases of normal conjunctiva. The positive expression of HB-EGF in pterygium head group was higher than that in body group after ANOVA (P0.05). The positive expression in body group was higher than that in normal conjunctiva group (P0.05). The positive expression in head group was significantly higher than that in normal conjunctiva group (P0.01). The results of Western Blotting showed that HB-EGF was expressed in primary pterygium head, body and normal conjunctiva. HB-EGF expression was the strongest in pterygium head, second in body and weakest in normal conjunctiva. The positive expression of pterygium head was higher than that of body part (P0.05), and the positive expression of body group was higher than that of normal conjunctiva group (P0.05). The positive expression of head was significantly higher than that of normal conjunctiva (P0.01). Conclusion: the overexpression of 1.HB-EGF in primary pterygium suggests that it is involved in the occurrence and development of pterygium. The expression of 2.HB-EGF in primary pterygium was stronger than that in body, suggesting that the role of 2.HB-EGF in pterygium was mainly in the head of pterygium.
【學(xué)位授予單位】:南昌大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2011
【分類號】:R777.33
【共引文獻(xiàn)】
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