單眼弱視患者空間視覺缺損特點(diǎn)及其機(jī)制
發(fā)布時(shí)間：2018-11-24 14:39
【摘要】：目的:評(píng)價(jià)單眼弱視者的空間視覺缺損及其與弱視程度的相關(guān)性,并基于M-P視覺通道理論分析單眼弱視空間視覺缺損的機(jī)制。方法:采用ETDRS數(shù)字視力表和OptecR6500視功能檢測(cè)儀檢測(cè)111例7~34歲單眼弱視者弱視眼和非弱視眼的視銳度和對(duì)比敏感度函數(shù),通過視銳度和對(duì)比敏感度函數(shù)衍生計(jì)算對(duì)比敏感度函數(shù)曲線下面積(AULCSF)、峰值對(duì)比敏感度(S max)、S max所對(duì)應(yīng)的空間頻率(Fr max)以及截止空間頻率(CutSF),分析單眼弱視者的空間視覺缺損特點(diǎn)及其與弱視程度的相關(guān)性。結(jié)果:單眼弱視者的弱視程度與雙眼對(duì)比敏感度AULCSF差值呈負(fù)相關(guān)(r=-0.83,P0.01),弱視眼視銳度與AULCSF、CutSF、S max、Fr max呈負(fù)相關(guān)(r值分別為-0.68、-0.80、-0.73和-0.56,P0.01)。不同程度弱視患者視銳度、AULCSF、S max、Fr max及CutSF間差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。不同程度弱視者非弱視眼視銳度、AULCSF、S max、Fr max及CutSF差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。輕度弱視者的弱視眼與非弱視眼AULCSF和Fr max差異也無統(tǒng)計(jì)學(xué)意義(P0.05),S max和CutSF差異有統(tǒng)計(jì)學(xué)意義(P0.05);而中重度弱視者弱視眼與非弱視眼AULCSF、S max、Fr max及CutSF差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。不同程度弱視者弱視眼在各空間頻率下對(duì)比敏感度差異均有統(tǒng)計(jì)學(xué)意義(P0.01),而非弱視眼間差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:視銳度與AULCSF、CutSF、S max、Fr max在弱視者空間視覺評(píng)價(jià)時(shí)呈現(xiàn)趨勢(shì)一致性。隨著弱視程度的加重,弱視眼的整體空間視覺功能逐漸下降,視覺系統(tǒng)的高頻端分辨率逐漸減弱和最佳對(duì)比度識(shí)別能力降低,最適空間頻率向低空間頻率偏移。在輕度弱視者中,M細(xì)胞通道無明顯異常,P細(xì)胞各亞型的敏感性下降;而中高度弱視者中,M和P細(xì)胞通道均受到不同程度的損傷,且以P細(xì)胞通道受損為主。
[Abstract]:Objective: to evaluate the spatial visual defect of monocular amblyopia and its correlation with amblyopia, and to analyze the mechanism of monocular amblyopia based on M-P visual channel theory. Methods: the visual acuity and contrast sensitivity function of amblyopia and non-amblyopic eyes were measured by ETDRS digital visual acuity meter and OptecR6500 visual function tester. The spatial frequency (Fr max) and cutoff frequency (CutSF), corresponding to the peak contrast sensitivity (S max), S max of area (AULCSF), under the contrast sensitivity function curve are calculated by derivation of acuity and contrast sensitivity function. To analyze the characteristics of spatial visual defect in monocular amblyopia and its correlation with amblyopia. Results: the degree of amblyopia in monocular amblyopia was negatively correlated with the contrast sensitivity (AULCSF) (r = -0.83, P0.01), and the acuity of amblyopia was negatively correlated with AULCSF,CutSF,S max,Fr max (r = -0.68) -0.80, respectively. -0.73 and -0.56p 0.01). There were significant differences in acuity, AULCSF,S max,Fr max and CutSF in amblyopic patients with different degrees of amblyopia (P0.01). There was no significant difference in acuity, AULCSF,S max,Fr max and CutSF in non-amblyopic eyes with different degrees of amblyopia (P0.05). There was no significant difference in AULCSF and Fr max between amblyopia and non-amblyopia in mild amblyopia (P0.05), S max and CutSF (P0.05). The AULCSF,S max,Fr max and CutSF of amblyopia and non amblyopia in moderate and severe amblyopia were significantly different (P0.01). The contrast sensitivity of amblyopia eyes with different degrees of amblyopia had statistical significance at each spatial frequency (P0.01), but there was no significant difference between non-amblyopic eyes (P0.05). Conclusion: acuity and AULCSF,CutSF,S max,Fr max are consistent in spatial visual evaluation of amblyopia. With the aggravation of amblyopia, the overall spatial visual function of amblyopia drops gradually, the high frequency end resolution of the visual system weakens and the recognition ability of the best contrast decreases, and the optimum spatial frequency shifts to the low spatial frequency. In the patients with mild amblyopia, the M cell channel was not abnormal, but the sensitivity of P cell subtypes was decreased, while in the middle and high degree amblyopia group, M and P cell channels were damaged to varying degrees, and P cell channel was mainly damaged.
【作者單位】： 湖州師范學(xué)院附屬第一醫(yī)院眼科;浙江大學(xué)附屬第二醫(yī)院眼科中心;浙江工業(yè)大學(xué)信息智能與決策優(yōu)化研究所;
【基金】：浙江省科技計(jì)劃項(xiàng)目(2009C33133) 浙江省醫(yī)藥衛(wèi)生科技計(jì)劃(2012KYA102) 浙江省重點(diǎn)實(shí)驗(yàn)室基金(2011E10006) 浙江省眼科創(chuàng)新團(tuán)隊(duì)基金(2009R50039)
【分類號(hào)】：R777.44
[Abstract]:Objective: to evaluate the spatial visual defect of monocular amblyopia and its correlation with amblyopia, and to analyze the mechanism of monocular amblyopia based on M-P visual channel theory. Methods: the visual acuity and contrast sensitivity function of amblyopia and non-amblyopic eyes were measured by ETDRS digital visual acuity meter and OptecR6500 visual function tester. The spatial frequency (Fr max) and cutoff frequency (CutSF), corresponding to the peak contrast sensitivity (S max), S max of area (AULCSF), under the contrast sensitivity function curve are calculated by derivation of acuity and contrast sensitivity function. To analyze the characteristics of spatial visual defect in monocular amblyopia and its correlation with amblyopia. Results: the degree of amblyopia in monocular amblyopia was negatively correlated with the contrast sensitivity (AULCSF) (r = -0.83, P0.01), and the acuity of amblyopia was negatively correlated with AULCSF,CutSF,S max,Fr max (r = -0.68) -0.80, respectively. -0.73 and -0.56p 0.01). There were significant differences in acuity, AULCSF,S max,Fr max and CutSF in amblyopic patients with different degrees of amblyopia (P0.01). There was no significant difference in acuity, AULCSF,S max,Fr max and CutSF in non-amblyopic eyes with different degrees of amblyopia (P0.05). There was no significant difference in AULCSF and Fr max between amblyopia and non-amblyopia in mild amblyopia (P0.05), S max and CutSF (P0.05). The AULCSF,S max,Fr max and CutSF of amblyopia and non amblyopia in moderate and severe amblyopia were significantly different (P0.01). The contrast sensitivity of amblyopia eyes with different degrees of amblyopia had statistical significance at each spatial frequency (P0.01), but there was no significant difference between non-amblyopic eyes (P0.05). Conclusion: acuity and AULCSF,CutSF,S max,Fr max are consistent in spatial visual evaluation of amblyopia. With the aggravation of amblyopia, the overall spatial visual function of amblyopia drops gradually, the high frequency end resolution of the visual system weakens and the recognition ability of the best contrast decreases, and the optimum spatial frequency shifts to the low spatial frequency. In the patients with mild amblyopia, the M cell channel was not abnormal, but the sensitivity of P cell subtypes was decreased, while in the middle and high degree amblyopia group, M and P cell channels were damaged to varying degrees, and P cell channel was mainly damaged.
【作者單位】： 湖州師范學(xué)院附屬第一醫(yī)院眼科;浙江大學(xué)附屬第二醫(yī)院眼科中心;浙江工業(yè)大學(xué)信息智能與決策優(yōu)化研究所;
【基金】：浙江省科技計(jì)劃項(xiàng)目(2009C33133) 浙江省醫(yī)藥衛(wèi)生科技計(jì)劃(2012KYA102) 浙江省重點(diǎn)實(shí)驗(yàn)室基金(2011E10006) 浙江省眼科創(chuàng)新團(tuán)隊(duì)基金(2009R50039)
【分類號(hào)】：R777.44
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