【摘要】：研究背景和目的： 隨著社會的進步,人口素質(zhì)的提高,干眼癥的不適癥狀也越來越受到大家的關(guān)注。干眼癥的病因十分復(fù)雜,目前,臨床上仍大多應(yīng)用人工淚液來治療。本研究應(yīng)用Smart Plug(?)目小管塞治療干眼癥,通過封閉患者淚小管以阻止淚液排出,使正常分泌的淚液滯留在眼內(nèi),從而改善干眼癥狀。評價應(yīng)用Smart Plug淚小管塞治療干眼癥的臨床效果。 方法： 收集2009年1月～2010年5月在武警醫(yī)院眼科門診的患者作為研究對象,應(yīng)用Smart Plug淚小管塞治療干眼癥患者42例(84眼),隨訪5-15月,平均8.3個月,根據(jù)SchirmerI試驗(SIT)、淚膜破裂時間(TBUT)、角膜熒光素染色(FL),觀察臨床療效。 結(jié)果： 1.治療前后SchirmerI試驗(SIT)分別為3.41±0.60mm和5.75±0.44mm(P0.05)；2.治療前后淚膜破裂時間(TBUT)分別為3.75±1.26秒和6.46±1.47秒(P0.05)；3.角膜熒光素染色(FL)評分分別為2.45±0.06分和0.04±0.02分(P0.05)；4.病人主觀癥狀改善。以上檢查差異均有統(tǒng)計學(xué)意義。 結(jié)論： 應(yīng)用Smart Plug淚小管塞治療干眼癥,封閉患者部分淚小管以阻止淚液的排出,使正常分泌的淚液在眼內(nèi)滯留,從而改善癥狀,取得較好的療效。它既顯著簡化了操作步驟及難度,也大大降低自體排除率、塞子丟失率及淚道繼發(fā)感染率。改善了干眼癥病人的眼表生理微環(huán)境,提高了病人的生活質(zhì)量。值得進一步臨床研究和推廣。
[Abstract]:Background and objective: with the progress of society and the improvement of population quality, the discomfort of xerophthalmia has attracted more and more attention. The etiology of xerophthalmia is very complicated. At present, artificial tear is still used in clinic. Smart Plug (? By blocking the lacrimal tubules of the patients to prevent the discharge of tears, the normally secreted tears remain in the eyes, thus improving the xerophthalmia. To evaluate the clinical effect of Smart Plug lacrimal tubule plug in the treatment of xerophthalmia. Methods: from January 2009 to May 2010, 42 patients (84 eyes) with dry eye were treated with Smart Plug lacrimal canaliculus plug. The patients were followed up for 5 to 15 months with an average of 8.3 months. According to SchirmerI test (SIT), tear film rupture time (TBUT), corneal fluorescein staining (FL), to observe the clinical curative effect. Results: 1. The (SIT) of SchirmerI test before and after treatment were 3.41 鹵0.60mm and 5.75 鹵0.44mm, respectively (P0.05). The tear film rupture time (TBUT) before and after treatment was 3.75 鹵1.26 seconds and 6.46 鹵1.47 seconds respectively (P0.05). The (FL) scores of corneal fluorescein staining were 2.45 鹵0.06 and 0.04 鹵0.02 (P0.05), respectively. The patient's subjective symptoms improved. The differences were statistically significant. Conclusion: using Smart Plug lacrimal tubule plug to treat dry eye, blocking part of lacrimal tubules in order to prevent the discharge of tear, so that the normal secretion of tears in the eyes, so as to improve the symptoms and obtain better curative effect. It not only simplifies the procedure and difficulty, but also reduces the rate of self exclusion, plug loss and secondary infection of lacrimal duct. The physiological microenvironment of dry eye patients was improved and the quality of life was improved. It is worth further clinical research and promotion.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R777.2

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