【摘要】：目的:分析與探討慢性鼻竇炎、鼻息肉與下呼吸道炎性疾病支氣管哮喘、以及其與支氣管哮喘肺功能阻塞程度的相關性。方法:對194例慢性鼻竇炎、鼻息肉患者的臨床資料進行回顧分析。根據(jù)病變范圍將慢性鼻竇炎分為單竇、多竇和全鼻竇3種類型;根據(jù)鼻內(nèi)鏡檢查及CT掃描結(jié)果將鼻息肉分成3級;下呼吸道炎性疾病支氣管哮喘、以及其與支氣管哮喘肺功能阻塞程度分為(小氣道阻塞呼吸功能障礙、肺通氣阻塞性障礙),同時是否伴發(fā)變應性鼻炎。分別對兩組患者的肺功能改變程度與疾病的病變范圍嚴重程度進行spearman相關分析檢驗,以-1r1,P0. 05為有相關性。結(jié)果:①慢性鼻竇炎組、慢性鼻竇炎伴息肉組支氣管哮喘及變應性鼻炎的發(fā)生率比較均無差異無統(tǒng)計學意義(P0.05)②慢性鼻竇炎組72例中29例合并支氣管哮喘(單竇、多竇和全鼻竇病變分別為2、19和8例);其中小氣道通氣功能阻塞患者(單竇、多竇和全鼻竇分別為2、11、6例),肺通氣功能阻塞患者(單竇、多竇和全鼻竇分別為0、8、2例)慢性鼻竇炎的病變范圍與哮喘患者肺功能(小氣道阻塞性通氣障礙、肺阻塞性通氣功能障礙)呈正相關(0r1,P0.05)。③慢性鼻竇炎伴鼻息肉組122例患者中并發(fā)支氣管哮喘43例,小氣道阻塞性通氣障礙Ⅰ-Ⅲ級分別為15、14、3例,肺阻塞性通氣功能障礙Ⅰ-Ⅲ級分別為5、5、1例.經(jīng)統(tǒng)計分析,在不同級別的慢性鼻竇炎伴鼻息肉患者,與哮喘患者肺功能(小氣道阻塞性通氣障礙、肺阻塞性通氣功能障礙)沒有相關性。(0r1,P0.05)。④竇口是否阻塞在兩組中與患者肺功能阻塞阻塞呼吸功能障礙、肺通氣阻塞性障礙呈正相關(0r1,P0.05)。結(jié)論:雖然上下呼吸道炎性疾病相關性的機制尚不明確,但慢性鼻竇炎、慢性鼻竇炎伴鼻息肉的疾病病變程度與支氣管哮喘肺功能阻塞程度有一定正相關性。
[Abstract]:Objective: to investigate the relationship between chronic sinusitis, nasal polyp and lower respiratory inflammatory diseases, bronchial asthma and pulmonary function obstruction. Methods: the clinical data of 194 patients with chronic sinusitis and nasal polyps were retrospectively analyzed. Chronic sinusitis is divided into three types according to the range of lesions: single sinus, multiple sinuses and total sinuses; nasal polyps are classified into three grades according to the results of nasal endoscopy and CT scan; bronchial asthma, a lower respiratory inflammatory disease, The degree of pulmonary function obstruction in bronchial asthma is divided into two groups: small airway obstruction, respiratory dysfunction, pulmonary ventilation obstructive disorder, and allergic rhinitis at the same time. The degree of pulmonary function change and the severity of disease in two groups were analyzed by spearman correlation test. 05 is related. Results there was no significant difference in the incidence of bronchial asthma and allergic rhinitis between the chronic sinusitis group and the chronic sinusitis with polyp group (P0.05) 2 there were 29 cases of bronchial asthma (single sinus) in the 72 cases of chronic sinusitis group. There were 219 cases with multiple sinuses and 8 cases with total paranasal sinus diseases, among which 6 patients with small airway function obstruction (2116cases with single sinus, 6 patients with multiple sinuses and 6 patients with total paranasal sinuses), patients with pulmonary ventilation dysfunction (monosinus), The pathological range of chronic sinusitis and pulmonary function (small airway obstructive ventilation disorder) in patients with chronic sinusitis were 0% and 82 cases, respectively. There were 43 cases of bronchial asthma in 122 cases of chronic sinusitis with nasal polyps, and 3 cases of small airway obstructive ventilation disorder 鈪，

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