【摘要】：目的:評估舌下特異性免疫治療(SLIT)螨過敏咽炎患者是否起效,探討不同治療方案、單一和多重過敏、性別等因素是否對SLIT起效有影響。方法:對我院53例螨過敏咽炎患者,進行治療前和治療6個月后的藥物總評分(TMS)和治療6個月后的患者自我療效評價。根據(jù)給藥方案將試驗組分為SLIT組、綜合組;根據(jù)點刺結果將試驗組分為塵螨組和多重組;根據(jù)性別將試驗組分為男性組和女性組。將25例僅接受對癥藥物治療的患者作為對照組。將對照組和試驗組以及試驗組中不同各組在治療6個月后的有效率和TMS減少比例進行比較。結果:試驗組有效率和TMS減少比均高于對照組,差異有統(tǒng)計學意義(P0.01)。SLIT組有效率為72.73%,綜合組為76.47%,兩者差異無統(tǒng)計學意義(P0.05);塵螨組有效率和TMS減少比分別為61.54%和94.46%,多重組分別為66.67%和71.25%,2組有效率和TMS減少比比較,差異無統(tǒng)計學意義(P0.05);女性組有效率和TMS減少比分別為83.33%和97.04%,男性組分別為58.33%和66.67%,2組有效率差異無統(tǒng)計學意義(P0.05),而2組TMS減少比差異有統(tǒng)計學意義(P0.05)。結論:SLIT對螨過敏咽炎患者有效;治療方案,單一和多重過敏對SLIT治療螨過敏咽炎患者無影響,性別有一定影響。
[Abstract]:Objective: to evaluate whether sublingual specific immunotherapy for (SLIT) mite hypersensitive pharyngitis is effective, and to explore whether different therapeutic schemes, single and multiple allergies, and sex have influence on the SLIT response. Methods: 53 patients with hypersensitive pharyngitis of mite were evaluated by (TMS) before treatment and 6 months after treatment. The experimental group was divided into SLIT group and comprehensive group according to the drug administration scheme, the experimental group was divided into dust mites group and multiple recombination group according to the prick results, and the experimental group was divided into male and female groups according to sex. Twenty-five patients with symptomatic drug therapy were used as control group. The effective rate and the ratio of TMS reduction were compared between the control group and the experimental group and the different groups in the test group after 6 months of treatment. Results: the effective rate and TMS reduction ratio in the experimental group were higher than those in the control group. The difference was statistically significant (P0.01). The effective rate of SLIT group was 72.733.There was no significant difference between the two groups (P0.05), the effective rate and TMS reduction ratio of dust mite group were 61.54% and 94.46%, the effective rate of multiple recombination group were 66.67% and 71.25%, respectively. There was no significant difference (P0.05); the effective rate and TMS reduction ratio were 83.33% and 97.04 in female group, 58.33% and 66.67% in male group, respectively (P0.05), but there was significant difference in TMS reduction ratio between two groups (P0.05). Conclusion the treatment of hypersensitive pharyngitis patients with mites by SLIT is effective, and the single or multiple allergies have no effect on the treatment of hypersensitive pharyngitis by SLIT, and the sex has some influence on the patients with hypersensitive pharyngitis.
【作者單位】： 安徽醫(yī)科大學附屬安慶醫(yī)院;安慶市立醫(yī)院耳鼻咽喉科;
【分類號】：R766.14

【參考文獻】

相關期刊論文 前7條

1 程靜;桂曉鐘;;粉塵螨滴劑對3～14歲支氣管哮喘和過敏性鼻炎的療效及安全性分析[J];安徽醫(yī)藥;2009年08期

2 吳建平;梅志丹;陶澤璋;耿惠君;;變態(tài)反應性咽炎的診斷和治療[J];臨床耳鼻咽喉科雜志;2006年22期

3 周麗楓;王潔;陳彥球;羅仁忠;陶佳;聶明榮;劉碧霞;李玉云;;舌下含服粉塵螨滴劑治療多種變應原過敏的變應性鼻炎兒童的療效與安全性評估[J];臨床耳鼻咽喉頭頸外科雜志;2012年20期

4 陳建軍;孔維佳;項濟生;舒宏;施秋梅;檀慧芳;周月;;標準化粉塵螨滴劑治療變應性鼻炎的半年期療效及安全性研究[J];華中科技大學學報(醫(yī)學版);2008年06期

5 呂學仿;馬力學;;慢性咽炎的綜合治療[J];人民軍醫(yī);2012年09期

6 曹蘭芳;陸權;顧洪亮;陳燕萍;張源;陸敏;錢耀琴;李嵐;許以平;;舌下含服粉塵螨滴劑治療兒童過敏性哮喘和變應性鼻炎的臨床評價[J];中華兒科雜志;2007年10期

7 張宏;;藍芩口服液對慢性咽炎患者IL-2、TNF-α、免疫細胞亞群及臨床癥狀的改善作用研究[J];現(xiàn)代中西醫(yī)結合雜志;2013年02期

【共引文獻】

相關期刊論文 前10條

1 陳宗鑫;何薇;何莉;;屋塵螨脫敏治療對變應性鼻炎特異性IgG_4抗體的影響[J];安徽醫(yī)學;2011年01期

2 黃學勤;程學仕;王俊芳;楊洋;;粉塵螨滴劑治療變應性鼻炎的臨床療效及安全性觀察[J];安徽醫(yī)藥;2010年06期

3 王瑾;吳昊;;特異性免疫治療變應性支氣管哮喘62例療效觀察[J];安徽醫(yī)藥;2011年08期

4 馬香萍;多力坤;;舌下特異性免疫治療對塵螨過敏性哮喘兒童的作用[J];中國當代兒科雜志;2010年05期

5 王曉玲;趙一鳴;;舌下脫敏療法在兒童過敏性哮喘中的應用[J];兒科藥學雜志;2009年06期

6 楊海燕;黃英;;兒童哮喘舌下特異性免疫治療的療效及安全性[J];兒科藥學雜志;2011年01期

7 王小琴;;粉塵螨滴劑治療過敏性鼻炎120例療效分析[J];蚌埠醫(yī)學院學報;2012年06期

8 楊羿容;朱德姝;徐小鴻;;鼻內(nèi)鏡手術治療鼻源性慢性咽炎90例臨床分析[J];重慶醫(yī)學;2012年19期

9 鄭伯強;王桂蘭;楊賽;;粉塵螨滴劑舌下特異性免疫治療對兒童咳嗽變異性哮喘的有效性[J];中國當代兒科雜志;2012年08期

10 沈f，

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