【摘要】：目的：了解濟(jì)南市眼科醫(yī)院眼科門診過(guò)敏性結(jié)膜炎的臨床分布特征和應(yīng)用0.1%鹽酸奧洛他定聯(lián)合0.1%普拉洛芬滴眼液治療的初步效果。研究對(duì)象：濟(jì)南市眼科醫(yī)院眼科門診294例過(guò)敏性結(jié)膜炎患者。 方法：將294例病例隨機(jī)分成兩組：對(duì)照組147例,單用0.1%奧洛他定滴眼液.試驗(yàn)組147例,聯(lián)合應(yīng)用0.1%普拉洛芬滴眼液與0.1%奧洛他定滴眼液,普拉洛芬每日點(diǎn)眼4次,奧洛他定每日點(diǎn)眼2次,每次1-2滴,兩種藥物間隔5分鐘。于點(diǎn)藥前、點(diǎn)藥后30分鐘、7天、14天評(píng)價(jià)患者癥狀和體征分值以及觀察兩組的有效率差別。 主要指標(biāo)：過(guò)敏性結(jié)膜炎的臨床類型特點(diǎn)、年齡分布、伴發(fā)過(guò)敏性鼻炎及過(guò)敏性哮喘的情況以及兩組癥狀、體征分值比較,兩組的有效率比較。 結(jié)果：過(guò)敏性結(jié)膜炎好發(fā)于中青年,12—55歲發(fā)病比例占84.7%,小于12歲少兒僅占6.1%,大于55歲患者占7.8%：患病與性別無(wú)關(guān)；有50%的患者同時(shí)伴有過(guò)敏性鼻炎,33.3%的患者同時(shí)伴有過(guò)敏性哮喘,16.3%的患者有家族史。臨床分布中,常年性過(guò)敏性結(jié)膜炎和季節(jié)性過(guò)敏性結(jié)膜炎為主要的類型,占63.9%；年齡分布中,春季角結(jié)膜炎在兒童中占23.1%,明顯高于成年人的6.6%,而特應(yīng)性角膜結(jié)膜炎和巨乳頭結(jié)膜炎所占的比例小于12.5%。 兩組患者在治療前的性別及癥狀、體征評(píng)分差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療前、治療后30分鐘,對(duì)照組與試驗(yàn)組的總評(píng)分值分別為21.95±3.01與21.84±3.34(P=0.7670),20.10±3.59與18.82±3.11(P=0.0013),兩組比較無(wú)統(tǒng)計(jì)學(xué)差異。治療后7天總評(píng)分值分別為11.89±3.96與8.39±3.39(P=0.0000),14天分別為9.25±4.18與5.29±3.56(P=0.0000),差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。對(duì)照組與試驗(yàn)組在治療7d后有效率分別為51.7%與66.0%；治療14 d后有效率分別為72.1%及98.6%。差異均有非常顯著的統(tǒng)計(jì)學(xué)意義(P0.01)。試驗(yàn)組未見(jiàn)明顯用藥后不適感與副作用。 結(jié)論：我國(guó)過(guò)敏性結(jié)膜炎好發(fā)于中青年�；疾∨c性別無(wú)關(guān)。同時(shí)患有過(guò)敏性鼻炎及過(guò)敏性哮喘的比例較高。以常年性過(guò)敏性結(jié)膜炎和季節(jié)性過(guò)敏性結(jié)膜炎為主要類型,春季角結(jié)膜炎在兒童患病比例較高。0.1%鹽酸奧洛他定聯(lián)合0.1%普拉洛芬滴眼液對(duì)緩解過(guò)敏性結(jié)膜炎癥狀與體征具有顯著效果,提高治療的有效率,起效快,縮短用藥時(shí)間,依從性好,無(wú)嚴(yán)重不良反應(yīng)發(fā)生。
[Abstract]:Objective: to investigate the clinical distribution of allergic conjunctivitis in ophthalmological outpatient of Jinan Ophthalmology Hospital and the preliminary effect of 0.1% olotazidine hydrochloride combined with 0.1% Praproprofen eye drops in the treatment of allergic conjunctivitis. Participants: 294 patients with allergic conjunctivitis in ophthalmological clinic of Jinan Ophthalmology Hospital. Methods: 294 cases were randomly divided into two groups: control group (147 cases) with 0.1% olitadine eye drops. 147 patients in the trial group were treated with 0.1% Praproprofen eye drops and 0.1% oloatadine eye drops, 4 times a day for Praprofen and 1-2 drops for each time, and 2 times a day, with a 5 minute interval between the two drugs. The scores of symptoms and signs and the difference of effective rate between the two groups were evaluated before and 30 minutes after administration. Main outcome measures: clinical type, age distribution, allergic rhinitis and allergic asthma, as well as the scores of symptoms and signs of the two groups, the effective rate of the two groups were compared. Results: the incidence rate of allergic conjunctivitis was 84.7in the middle and young adults aged 12-55 years, only 6.1 in children younger than 12 years old, 7.8 in patients older than 55 years old: the disease had nothing to do with sex; 50% of the patients were accompanied with allergic rhinitis (33. 3%) and 16. 3% of the patients with allergic asthma (16. 3%) had a family history. In clinical distribution, perennial allergic conjunctivitis and seasonal allergic conjunctivitis were the main types, accounting for 63.9%. The proportion of keratoconjunctivitis in children in spring was 23.1cm, which was significantly higher than that in adults (6.6%), while the proportion of atopic keratoconjunctivitis and giant papillary conjunctivitis was less than 12.5%. There was no significant difference in the scores of gender, symptoms and signs between the two groups before treatment (P0.05). Before and 30 minutes after treatment, the total scores of control group and experimental group were 21.95 鹵3.01 and 21.84 鹵3.34 (P0. 7670), 20.10 鹵3. 59 and 18. 82 鹵3. 11 (P0. 0013), respectively. There was no significant difference between the two groups. The total scores were 11.89 鹵3.96 and 8.39 鹵3.39 (P0. 0000) and 9. 25 鹵4. 18 and 5. 29 鹵3. 56 (P0. 0000) on the 7th day after treatment, respectively. The difference was statistically significant (P0.01). The effective rates of the control group and the experimental group were 51.7% and 66.0% after 7 days treatment, and 72.1% and 98.6% after 14 days treatment, respectively. The difference was statistically significant (P0.01). There was no obvious discomfort and side effects in the test group. Conclusion: allergic conjunctivitis is more common in young and middle-aged people in China. The disease has nothing to do with sex. The proportion of allergic rhinitis and allergic asthma is high. The main types are perennial allergic conjunctivitis and seasonal allergic conjunctivitis. Spring keratoconjunctivitis has a significant effect on relieving symptoms and signs of allergic conjunctivitis with 0.1% olotaadine hydrochloride and 0.1% Praproprofen eye drops in children. The effective rate of treatment is improved, the effective rate is fast, and the time of medication is shortened. Compliance was good and no serious adverse reactions occurred.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R777.3

【引證文獻(xiàn)】

中國(guó)期刊全文數(shù)據(jù)庫(kù) 前1條

1 關(guān)艷秋;;過(guò)敏性結(jié)膜炎應(yīng)用奧洛他定聯(lián)合普拉洛芬滴眼液的臨床價(jià)值分析[J];中國(guó)衛(wèi)生產(chǎn)業(yè);2013年25期

，

本文編號(hào)：2144084